琥珀酸曲格列汀对db/db小鼠CYP450酶和药物转运体的影响*

桓芝兰,朵德龙,赵妮,常亚娥,王亚峰

Effects of Trelagliptin Succinate on CYP450 Enzymes and Drug Transporters in db/db Mice

Zhilan HUAN,Delong DUO,Ni ZHAO,Yae CHANG,Yafeng WANG

图3 4组小鼠肝脏中CYP3A4和CYP2D6 mRNA和蛋白表达水平的比较($\bar{x}\times s$,n=6) A.正常对照组;B.模型对照组;C.琥珀酸曲格列汀组;D.磷酸西格列汀组;①与正常对照组比较,t=2.193~19.202,P<0.05;②与模型对照组比较,t=-4.449,P<0.05;③与琥珀酸曲格列汀组比较,t=2.165,5.740,P<0.05。

Fig.3 Comparison of CYP3A4 and CYP2D6 mRNA and protein expression levels in livers of four groups of mice ($\bar{x}\times s$,n=6) A.normal control group;B.model control group;C.trelagliptin succinate group;D.sitagliptin phosphate group.①compared with normal control group,t=2.193-19.202,P<0.05;②compared with model control group,t=-4.449,P<0.05;③compared with trelagliptin succinate group,t=2.165,5.740,P<0.05.