苦参碱逆转外排泵系统AcrAB-ToIC介导的耐碳青霉烯类肺炎克雷伯菌对替加环素的耐药性*

伍慧妍,钟瑶,詹铀超,彭亮,张艳玲

Matrine Reverses Efflux Pump System AcrAB-ToIC Mediated Tigecycline Resistance of Carbapenem-resistant Klebsiella Pneumoniae

Huiyan WU,Yao ZHONG,Youchao ZHAN,Liang PENG,Yanling ZHANG

图4 CRKP-TR组中替加环素耐药(R)与中介(I)在联合药物作用后外排泵膜蛋白基因表达情况

Fig.4 Gene expression levels of AcrAB-TolC between tigecycline-resistant and intermediate CRKP strains after tigecycline and matrine combination intervention