基于模拟退火算法的适当集总法简化茶碱生理药动学模型*

梁露花,黄叶真,普思静,郑浩东,刘欣然,项荣武

A Lumped and Simplified Physiological Pharmacokinetic Model of Theophylline Based on Simulated Annealing Algorithm

Luhua LIANG,Yezhen HUANG,Sijing PU,Haodong ZHENG,Xinran LIU,Rongwu XIANG

图1 温度变化趋势(左)和经过迭代后对最优ARD%解的收敛(右)

Fig.1 Temperature change trend (left) and convergence to the optimal ARD% solution after iteration (right)