中国科技论文统计源期刊 中文核心期刊  
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊  
日本科学技术振兴机构数据库(JST)
第七届湖北十大名刊提名奖  
医药导报, 2017, 36(9): 1051-1053
doi: 10.3870/j.issn.1004-0781.2017.09.026
快速康复干预腹腔镜胆囊切除术围手术期抗菌药物的合理应用
郭文娟, 丁丽, 周承刚, 王惠霞

摘要:

目的 探讨采用快速康复干预的腹腔镜胆囊切除手术围手术期抗菌药物的合理应用。方法 胆囊切除患者1 112例,其中558例患者实施传统腹腔镜胆囊切除术(A组),554例患者实施快速康复干预腹腔镜胆囊切除术(B组),比较两组围手术期抗菌药物使用率、抗菌药物费用、用药品种及住院时间等情况。结果 B组较A组抗菌药物使用率降低71.00%;药物费用占比降低64.25%;抗菌药物使用合理率明显提高。结论 应用快速康复干预措施可显著改善围手术期抗菌药物不合理应用现状,降低抗菌药物使用率,减少住院费用以及住院时间,提高患者康复水平,具有良好社会效益。

关键词: 抗菌药物 ; 快速康复 ; 切除术,胆囊,腹腔镜

Abstract:

腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)是胆道外科常用手术[1],目前已成为胆囊良性疾病外科治疗的金标准[2]。为保证治疗过程顺利,临床医生常常预防或术后使用抗菌药物,但是能否应用及如何应用目前存在争议[3-5],因此进行抗菌药物合理应用管理成为医院所追求的目标。目前我国外科围手术期抗菌药物不合理应用主要体现在无指征用药、用药时机不当、使用药物品种不正确及无指征联合用药等方面[6]。我院已开展多年的外科手术抗菌药物管控,在一定程度上减少了不必要的医疗资源浪费,提高抗菌药物使用合理性[7],然而单纯靠制度的约束并未达到预期效果,借由医院引进康复外科理念时机,开展抗菌药物在LC手术中合理应用具有重要意义[8-9]。快速康复外科(fast frack surgery,FTS)是近年来欧美一些国家极力推广的能够加快康复的理念[10],一般包括以下几个重要内容:①患者手术前的教育;②更好的麻醉、镇痛及外科技术以减少手术应激反应、疼痛及不适反应;③强化手术后康复治疗,包括早期下床活动及肠内营养。创建标准治疗方案及完善的组织实施是保证其成功的重要前提,而良好的外科技术及优质护理是减少抗菌药物应用及提高合理应用的关键,同样,FTS也依赖于一些重要围手术期治疗方法的整合[11-12]。通过在手术前、手术中及术后应用各种已证实有效的方法以减少手术应激、并发症以及不必要的治疗,明显缩短患者住院时间,显著加快患者手术后康复速度,能够在一定程度上降低抗菌药物的使用率,减少不合理应用。2012年3月—2016年9月,笔者观察了快速康复干预的LC与传统LC中抗菌药物使用情况,分析快速康复在控制抗菌药物的合理使用方面的作用。

1 资料与方法
1.1 临床资料

随机抽取我院接受LC患者1 200例,统计姓名、年龄、性别、诊断、入出院时间和抗菌药物使用类别、名称、使用方法、剂量、药物使用时间、联合应用等,传统LC及快速康复LC均为600例。纳入标准为单纯性胆结石、慢性胆囊炎、胆囊结石、胆囊息肉、肝内胆管结石患者,美国麻醉医师协会(American Society of Anesthesiologists,ASA) 评分等级为Ⅰ~Ⅲ级,年龄25~72岁,男女比例0.82:1。剔除标准:剔除糖尿病、冠心病、严重心肺功能损伤及手术前感染并发症等。最后纳入接受传统LC患者 558例(A组),接受快速康复干预LC患者554例(B组)。

1.2 方法

A组实施传统LC,手术前常规护理,手术前禁食12 h,禁饮4 h,手术中无特定保暖,手术中补液3.5~5 L,手术前0.5~2 h预防使用抗菌药物1次,手术后使用抗菌药物3~5 d,排气后恢复饮食以及常规疼痛护理。B组实施快速康复理念干预下的LC,重视手术前、手术后教育及护理,手术前8 h禁食,2 h禁饮,并在手术前适当饮用糖水等增加对手术的耐受性,全程采用保温措施,手术前0.5~2 h预防应用抗菌药物1次或不用,手术后不再使用,手术中补液约2 L,手术后鼓励早期活动及进食[13]。两组患者年龄、性别等均差异无统计学意义(均P>0.05),具有可比性。

1.3 观察指标及评价标准

观察指标:抗菌药物使用类别、使用时间、是否联合用药、抗菌药物费用占比和住院时间等。按照《抗菌药物临床应用指导原则2015年版》《卫生部办公厅关于抗菌药物临床应用管理有关问题的通知》、《2016 WSES指南》[14]、《医院抗菌药物临床应用专项整治活动方案》等制定LC预防性应用抗菌药物标准。

1.4 统计学方法

采用SPSS16.0版统计学软件进行数据处理,计量资料采用均数±标准差( x ¯ ±s)表示,组间均数采用t检验,计数资料采用χ2检验。以 P<0.05为差异有统计学意义。

2 结果
2.1 抗菌药物使用率及抗菌药物费用占比

应用快速康复外科理念规范LC后,抗菌药物使用率显著下降,抗菌药物费用显著降低。与A组比较,B组抗菌药物使用率下降71.00%(P<0.05);B组抗菌药物费用占比较A组下降64.25%(P<0.05)。见表1。

表1 两组抗菌药物使用率及抗菌药物费用占比
组别 例数 使用抗菌药物 总药物
费用/元
抗菌药物
费用/元
抗菌药物费
用占比/%
%
A组 558 375 67.20 7 746.76±140.16 1 709.40±98.50 22.07
B组 554 108 19.49 4 271.67±135.27 336.78±67.31 7.89

表1 两组抗菌药物使用率及抗菌药物费用占比

2.2 抗菌药物类别

传统LC抗菌药物使用频次依次为替硝唑、头孢呋辛、左氧氟沙星、奥硝唑、克林霉素、氨苄西林、头孢哌酮/舒巴坦等,可见抗菌药物主要集中在硝基咪唑类及第2代、第3代头孢菌素类抗菌药;快速康复LC使用抗菌药物频次依次为头孢呋辛、替硝唑、左氧氟沙星、头孢哌酮/舒巴坦、奥硝唑、头孢唑林等。部分药物使用率在B组有降低趋势,但差异无统计学意义,应用抗菌药物种类较A组减少2类。见表2。

表2 两组抗菌药物使用类别 例
组别 例数 第1代头孢
菌素类
第2代头孢
菌素类
第3代头孢
菌素类
第4代头孢
菌素类
A组 558 126 70 39 20
B组 554 64 44 13 0
组别 硝基咪
唑类
单环β-
内酰胺类
林可
霉素类
氟喹
诺酮类
氨基
苷类
A组 51 38 58 30 16
B组 5 25 15 25 0

表2 两组抗菌药物使用类别 例

2.3 手术基本情况

表3。B组较A组住院时间显著下降58.43%(P<0.05),手术中补液量下降55.56%(P<0.05),手术后开始排气时间缩短54.15%(P<0.05),预防性应用抗菌药物、手术后用药显著下降,分别下降91.67%,98.00%,应用快速康复干预后无手术中追加用药。两组手术时间差异无统计学意义(P>0.05)。

表3 两组手术情况及抗菌药物在围手术期应用情况 ヌ±s
组别 例数 平均住院
时间/ d
手术中补液
总量/L
手术平均
时间/d
A组 558 8.9±1.1 4.5±0.2 3.0±0.3
B组 554 3.7±1.9 2.0±0.3 2.8±0.3
组别 手术后开始
排气时间/h
预防性
用药
手术中
追加用药
手术后
用药
A组 48.35±3.56 120 68 100
B组 22.17±4.81 10 0 2

表3 两组手术情况及抗菌药物在围手术期应用情况 ヌ±s

2.4 抗菌药物使用合理性

A组预防性抗菌药物应用不合理主要表现为选药、剂量、联合用药不合理,用药时间过长及无指针用药。B组抗菌药物联用种类减少,合理性显著提高。见表4。与A组相比B组抗菌药物选择合理率上升30.60%(P<0.05),联合用药合理率上升43.12%(P<0.05),超剂量用药下降42.59%(P<0.05),超长时间用药下降75.51%(P<0.05)。

表4 两组抗菌药物应用合理性
组别 使用抗菌
药物/例
选药合理 联合用药/
联合用药合理 超剂量 持续时间>24 h
% % % %
A组 375 241 64.27 225 119 52.89 121 32.27 98 26.13
B组 108 100 92.59 57 53 92.98 20 18.52 7 6.48

表4 两组抗菌药物应用合理性

3 讨论

相比较常规抗菌药物控制措施,启用快速康复干预LC能够显著降低抗菌药物的使用率,减少患者医药费用和住院时间,能显著减少抗菌药物的使用费用,提高抗菌药物合理使用水平。

胆道在正常情况下是无菌环境,生理屏障被破坏及外科手术介入等会引起细菌入侵。胆道菌群以革兰阴性菌为主,且主要是大肠埃希菌等[15]。本研究显示,两组患者均应用头孢唑林,对革兰阳性菌如金黄色葡萄球菌、溶血性链球菌、肺炎球菌、白喉杆菌及梭状芽胞杆菌等有比较强的作用,对革兰阴性菌的作用也较强。从病例分析来看,应用头孢唑林患者符合抗菌药物应用相关要求[16]。但传统LC应用最多的为硝基咪唑类及第2代、第3代头孢菌素类药物,而快速康复外科干预手术中由于有效保护措施如全程保温,减少应激,麻醉方式改变减少患者痛苦的感知等方式能有效减少抗菌药物的使用,甚至可以不用[17-18]

传统LC最常见抗菌药物不合理应用为剂量不合理,例如头孢甲肟用于成人轻度感染时1~2 g·d-1,分2次静脉滴注,中重度感染可增至4 g·d-1,分2~4次静脉滴注,而部分患者预防性给药为每次3 g,剂量偏大。其次为选药不合理,例如某患者头孢唑林皮试阳性选用克林霉素预防,胆道系统感染主要以革兰阴性菌为主,克林霉素对革兰阳性菌及厌氧菌作用强,对革兰阴性菌无抗菌活性,抗菌谱不覆盖主要致病菌,因此并不建议选用克林霉素预防感染。在联合应用方面不合理性主要是未根据药物的实际特性进行选择[19-20]。这与传统手术过于依赖抗菌药物的使用有关,传统LC补液过多,手术中不采取保温措施使得患者应激增加,而盲目相信抗菌药物使得医生尽可能选择广谱及更高一级抗菌药物。

LC围手术期中不论是预防性还是治疗性应用抗菌药物都不能因单方面的因素肯定或者否定使用,诚然,适量的抗菌药物能起到有效控制手术感染发生,但不合理使用不仅增加患者经济负担,增大药物不良反应,而且会导致细菌耐药性增加。因此抗菌药物应用在LC围手术期需要因具体情况而定,并且应用药物种类需要严格按照相关指导原则,根据药物特性及抗菌谱有针对性选择用药。相对于常规抗菌药物控制措施,快速康复可有效减少手术中应激,提高围手术期护理能力,从根本上改变抗菌药物在LC中滥用现状,在医院实施抗菌药物合理应用方面起着重要作用,值得推广。

The authors have declared that no competing interests exist.

参考文献

[1] DE GEORGE M A,RANGEL M,NODA R W,et al.Laparo-scopic transumbilical cholecystectomy:surgical technique[J].JSLS,2009,13(4):536-541.
ABSTRACT Laparoscopic cholecystectomy is generally performed using 4 ports by transperitoneal access. Recent developments regarding laparoscopic surgery have been directed toward reducing the size or number of ports to achieve the goal of minimally invasive surgery, by minilaparoscopy, natural orifice access, and the transumbilical approach. The aim of this article is to describe our laparoscopic transumbilical cholecystectomy technique using conventional laparoscopic instruments and ports. The Veress needle was placed through the umbilicus, which allowed carbon dioxide inflow. A 5-mm trocar was placed in the periumbilical site for the laparoscope followed by the placement of 2 additional 5-mm periumbilical trocars. The entire procedure was performed using conventional laparoscopic instruments. At the end of the surgery, trocars were removed, and all 3 periumbilical skin incisions were united for specimen retrieval. Five transumbilical cholecystectomies were performed following this technique. The mean BMI was 26.6 kg/m(2). The mean operative time and blood loss were 46.2 minutes and 55 mL, respectively. No intraoperative complications occurred. Analgesia was performed using dipyrone (1g IV q6h) and ketoprofen (100 mg IV q12 h). Time to first oral intake was 8 hours. Mean hospital stay was 19.2 hours. Laparoscopic transumbilical cholecystectomy seems to be feasible even using conventional laparoscopic instruments and can be considered a potential alternative for traditional laparoscopic cholecystectomy.
DOI:10.4293/108680809X12589998404281      URL    
[本文引用:1]
[2] 曾巍. 腹腔镜胆囊切除术与开腹胆囊切除术治疗胆结石的疗效比较分析[J].中国医药指南,2016,14(8):40.
目的:比较分析腹腔镜胆囊切除术与开腹胆囊切除术治疗胆结石的疗效。方法本次研究对象为我院2012年6月至2015年6月收治的120例胆结石患者,随机选取60例患者为对照组,并采取开腹胆囊切除术治疗;随机选取60例患者为观察组,并采取腹腔镜胆囊切除术治疗。结果观察组的手术时间、术中出血量、胃肠功能恢复时间、医疗费用、不良反应发生率等观察指标均显著优于对照组(P<0.05)。结论腹腔镜胆囊切除术治疗胆结石的疗效显著优于开腹胆囊切除术。
[本文引用:1]
[3] GAUR A,PUJAHARI A K.Role of prophylactic antibiotics in laparoscopic cholecystectomy[J].Med J Armed Forces India,2010,66(3):228-230.
Conclusion: Antibiotic prophylaxis is not needed for laparoscopic cholecystectomy.
DOI:10.1016/S0377-1237(10)80043-7      PMID:27408307      URL    
[本文引用:1]
[4] SHAH J N,MAHARJAN S B,PAUDYAL S.Routine use of antibiotic prophylaxis in low-risk laparoscopic cholecys-tectomy is unnecessary:a randomized clinical trial[J].Asian J Surg,2012,35(4):136-139.
Routine preoperative antibiotic prophylaxis is not necessary in low-risk symptomatic gallstone patients undergoing laparoscopic cholecystectomy.
DOI:10.1016/j.asjsur.2012.06.011      PMID:23063084      URL    
[本文引用:0]
[5] 高晔. 围手术期抗菌药物的预防性应用现状[J].世界最新医学信息文摘,2013,13(20):213-214.
感染是最常见的手术后并发症,抗菌药物在围手术期的正确预防性应用有助于减少手术部位的感染(SSI),即发生在切口或手术深部器官或腔隙的感染。本文将从药物选择、用药时间和用药疗程等方面进行综述,今后要加大抗菌药物的监控与管理力度,以提高抗菌药物预防性使用的合理性。
[本文引用:1]
[6] 张晋萍,李俐,卞晓洁,.腹腔镜胆囊切除术围术期预防用药问题及对策[J].中国药房,2012,23(34):3180-3182.
URL    
[本文引用:1]
[7] 王惠霞,滕月鹏,古殿杰.抗菌药物专项整治前后我院腹腔镜胆囊切除术围术期抗菌药物预防性使用分析[J].中国药房,2015,26(5):579-582.
URL    
[本文引用:1]
[8] PATEL G N,RAMMOS C K,PATEL J V,et al.Further reduction of hospital stay for laparoscopic colon resection by modifications of the fast-track care plan[J].Am J Surg,2010,199(3):391-395.
Abstract BACKGROUND: Fast-track surgery has been described as a plan to facilitate early recovery. We present one surgeon's modifications to fast-track surgery for laparoscopic colectomy patients. METHODS: We performed a retrospective review of 48 consecutive patients undergoing elective laparoscopic colectomy treated by a modified fast-track plan between 2004 and 2008. Elements included preoperative education, pre-anesthesia dexamethasone, immediate postoperative general diet, no urinary catheter, no epidural anesthesia, and no flatus or bowel movement as a discharge requirement. Data collected included the following: age, sex, body mass index, resection indications, surgical time, blood loss, pain score, time to ambulation, time to bowel function, length of stay, complications, and mortality. RESULTS: The mean length of stay was 37 hours (1.5 d), with 29 of 48 patients discharged without passage of flatus or stool. Only 1 patient required readmission. CONCLUSIONS: Our modified fast-track plan achieved significant improvement in length of stay for laparoscopic colectomy compared with previous results. Copyright (c) 2010 Elsevier Inc. All rights reserved.
DOI:10.1016/j.amjsurg.2009.09.009      PMID:20226917      URL    
[本文引用:1]
[9] 贺云华,刘世坤.腹腔镜胆囊切除术患者围术期预防性应用抗菌药物的干预效果分析[J].中国医药指南,2013,11(17):53-54.
目的探讨腹腔镜胆囊切除术围术期预防性应用抗菌药物干预措施的效果与可行性。方法设干预组与非干预组进行对照研究,将医院干预前后反映抗菌药物使用情况的各项指标进行对比分析。结果实施干预后,抗菌药物使用基本合理,抗菌药物费用明显下降。结论本研究所实施的干预措施可行、有效,对促进安全、有效、经济使用抗菌药物有积极作用。
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[10] NANAVATI A J,NAGRAL S,PRABHAKAR S.Fast-track surgery in India[J].Natl Med J India,2014,27(2):79-83.
Abstract Fast-track surgery or 'enhanced recovery after surgery' or 'multimodal rehabilitation after surgery' is a form of protocolbased perioperative care programme. It is an amalgamation of evidence-based practices that have been proven to improve patient outcome independently and exert a synergistic effect when applied together. The philosophy is to treat the patient's pathology with minimal disturbance to the physiology. Several surgical subspecialties have now adopted such protocols with good results. The role of fast-track surgery in colorectal procedures has been well demonstrated. Its application to other major abdominal surgical procedures is not as well defined but there are encouraging results in the few studies conducted. There has been resistance to several aspects of this programme among gastrointestinal and general surgeons. There is little data from India in the available literature on the application of fast-tracking in gastrointestinal surgery. In a country such as India the existing healthcare structure stands to gain the most by widespread adoption of fast-track methods. Early discharge, early ambulation, earlier return to work and increased hospital efficiency are some of the benefits. The cost gains derived from this programme stand to benefit the patient, doctor and government as well. The practice and implementation of fast-track surgery involves a multidisciplinary team approach. It requires policy formation at an institutional level and interdepartmental coordination. More research is required in areas like implementation of such protocols across India to derive the maximum benefit from them. Copyright 2014, NMJI.
PMID:25471759      URL    
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[11] 张静. 微创治疗急性结石性胆囊炎的快速康复理念应用[J].中外医学研究,2014,12(3):95-96.
目的:观察快速康复理念(FTS)在急性结石性胆囊炎微创治疗手术中临床应用的效果。方法: 将128例急性结石性胆囊炎患者采用随机数字表法分为快速康复护理组(FTS组)和对照组,各64例。对照组接受常规护理,FTS组接受快速康复护理,观 察比较两组患者的治疗情况。结果:FTS组与对照组比较,进食、下床活动、排气、时间提前,而且术后住院时间短、住院费用显著低,差异均有统计学意义 (P&lt;0.05),但手术时间无明显差别(P&gt;0.05)。结论:快速康复外科理念在微创治疗急性结石性胆囊炎的应用上能够降低患者痛苦以及 并发症的发生率,有利于患者及早恢复,缩短住院时间,节省治疗费用。
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[12] 王成慧. 快速康复护理在肝胆外科手术中的护理应用[J].中国医药指南,2013,11(34):546-547.
目的:肝胆外科手术护理使用快速康复护理的研究分析。方法对文献资料进行翻阅,结合实际工作经验来进行研 究分析。结果快速康复护理对患者的手术质量和预后都能起到积极的促进作用,治疗周期缩短,患者经济负担减少。结论快速康复护理在手术治疗的应用将会越来越 广,可以为患者提供更好的医疗服务。
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[13] AKOH J A,WATSON W A,BOURNE T P.Day case laparoscopic cholecystectomy:reducing the admission rate[J].Int J Surg,2011,9(1):63-67.
Appropriate patient selection, sensible scheduling of operations and avoiding the use of drains will decrease unplanned admissions following DCLC. Although the time taken to perform procedures was higher for surgical trainees than consultants, this had no adverse outcome on patient outcome.
DOI:10.1016/j.ijsu.2010.09.002      PMID:20887821      URL    
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[14] ANSALONI L,PISANO M,COCCOLINI F,et al.2016 WSES guidelines on acute calculous cholecystitis[J].World J Emerg Surg,2016,11:25.
Acute calculus cholecystitis is a very common disease with several area of uncertainty. The World Society of Emergency Surgery developed extensive guidelines in order to cover grey areas. The diagnostic criteria, the antimicrobial therapy, the evaluation of associated common bile duct stones, the identification of “high risk” patients, the surgical timing, the type of surgery, and the alternatives to surgery are discussed. Moreover the algorithm is proposed: as soon as diagnosis is made and after the evaluation of choledocholitiasis risk, laparoscopic cholecystectomy should be offered to all patients exception of those with high risk of morbidity or mortality. These Guidelines must be considered as an adjunctive tool for decision but they are not substitute of the clinical judgement for the individual patient.
DOI:10.1186/s13017-016-0082-5      PMID:4908702      URL    
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[15] 刘适,蔡瑞云,李浩.胆道细菌感染的分布及药敏分析[J].实用预防医学,2012,19(12):1855-1857.
目的了解湖南省人民医院住院病 人胆道感染细菌分布及其对目前常用抗生素的敏感性。方法对2011年1月1日-2012年6月30日245例胆道疾病患者胆汁培养阳性所检出的280株细 菌及其药敏试验结果进行回顾性分析。结果检出革兰阴性细菌(G-菌)195株(69.6%),其中大肠杆菌78株(27.9%)、肺炎克雷伯菌39株 (13.9%)和铜绿假单胞菌22株(7.9%)分列前三位;革兰阳性球菌(G+球菌)83株(29.6%),其中粪肠球菌29株(10.4%)、屎肠球 菌13株(4.6%)和变异链球菌13株(4.6%)分列前三位;真菌(白色念珠菌)2株(0.7%)。G-菌主要对碳青霉烯类和氨基糖苷类药物敏 感;G+球菌主要对糖肽类、硝基呋喃类和碳青霉烯类药物敏感。结论胆道细菌感染的菌种分布和药敏情况较前均发生了变化,应尽可能作胆汁培养指导临床合理用 药,以减少耐药菌株的产生。
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[16] SARTELLI M,WEBER D G,RUPPE E,et al.Antimicrobia-ls:a global alliance for optimizing their rational use in intra-abdominal infections(AGORA)[J].World J Emerg Surg,2016,11:33.
Abstract [This corrects the article DOI: 10.1186/s13017-016-0089-y.].
DOI:10.1186/s13017-017-0147-0      PMID:28785301      URL    
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[17] 刘隽,倪平志,王俊,.快速康复外科理念在肝胆外科中的应用及疗效评价[J].临床外科杂志2013,21(9):681-683.
目的 研究快速康复外科(FTS)在肝胆外科应用的安全性及疗效.方法 我院2010年6月至2012年10月收治的肝胆外科接受不同手术治疗的98例患者随机分成实验组和对照组,对照组围手术期采用传统处理方法,实验组采用FTS围手术期处理方法,术后检测第1、3、5、7天的血清C反应蛋白(CRP)、白介素-6(IL-6)、IgA、IgG、CD4、CD8的阳性细胞值,CD4/CD8的比例,同时术后观察住院时间和术后并发症等指标.结果 实验组术后血清CRP、IL-6、IgA、IgG水平在术后第1、3、5天明显高于对照组,较对照组更快恢复术前的水平;CD4、CD8的阳性细胞值,以及CD4/CD8的比例在术后第1、3、5天明显高于对照组;而且实验组术后住院时间明显缩短,术后并发症与对照组基本一致.结论 FTS应用于肝胆外科术后患者的免疫功能恢复得更快,应激反应较低,有利于患者术后快速的康复,而且是完全安全和有效的.
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[18] 朱安东,邢金.快速康复技术在腹腔镜胆囊切除术围术期的应用[J].中国微创外科杂志,2014,14(8):701-703.
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[本文引用:1]
[19] 王金凤,常璠.某院普外科胆道细菌感染及耐药性分析[J].国际检验医学杂志,2013,34(3):322-324.
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[本文引用:1]
[20] YAN R C,SHEN S Q,CHEN Z B,et al.The role of prophy-lactic antibiotics in laparoscopic cholecystectomy in preventing postoperative infection:a meta-analysis[J].J Laparoendosc Adv Surg Tech A,2011,21(4):301-306.
Although laparoscopic cholecystectomy (LC) is a common and widely applied technique, the use of antibiotics during the perioperative period in infection prevention remains controversial. In our study, a meta-analysis was performed to assess the impact of antibiotic prophylaxis on the postoperative infection rate in LC.A literature search was conducted on studies published between January 1966 and March 2010 that involved LC and prophylactic administration of antibiotics. Only randomized trials that compared perioperative antibiotic prophylaxis with placebo or no treatment in low-risk patients undergoing LC were selected. Eighteen studies qualified according to the inclusion criteria, but only 12 were of adequate quality according to the Jadad scale to be included for the meta-analysis. Data were analyzed via the Peto odds ratio (OR) method and run using RevMan 4.2 software. The precision of the estimation of OR by individual studies was used to calculate their contribution (or weighting) to the pooled OR.The results of the 12 studies did not have significant heterogeneity, and thus, the fixed effect model was used for data analysis. Compared with placebo or no treatment, there was no significant risk reduction in the antibiotic prophylaxis group with regard to overall infections (OR=1.11; 95% confidence interval [CI], 0.68-1.82; P=.67), wound infections (OR=1.07; 95% CI, 0.59-1.94; P=.99), major infections (OR=2.88; 95% CI, 0.3-28.09; P=.36), distant infections (OR=1.01; 95% CI, 0.43-2.36; P=.99), or positive bile cultures (OR=0.76; 95% CI, 0.54-1.08; P=.12). However, prophylactic antibiotics did shorten length of hospital stay (weighted mean difference=-0.16; 95% CI, -0.22 to -0.09; P<.01).Prophylactic antibiotics are not necessary for elective LC in low-risk patients.
DOI:10.1089/lap.2010.0436      PMID:21443433      URL    
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关键词(key words)
抗菌药物
快速康复
切除术,胆囊,腹腔镜


作者
郭文娟
丁丽
周承刚
王惠霞