2012, 31(2): 150-152.
ObjectiveTo investigate protective effects of ligustrazine (tetramethypyrazine, TMP) on cisplatininduced oxidative injury of kidneys in rats. MethodsTMP was administered at 50，100 mg8226;kg－18226;d－1 body weight intraperitoneally (ip) for five consecutive days, 2 days before a single dose of cisplatin (DDP, 8 mg8226;kg－1，ip). The rats were sacrificed four hours after the last injection. Blood urea nitrogen(BUN) and serum creatinine (SCr) were tested, 24 hours urine were collected to detect urinary protein. The contents of malondialdehyde (MDA), glutathione (GSH) content, nitric oxide (NO), activities of superoxide dismutase (SOD), glutathioneStransferase (GST), the nitric oxide synthase (NOS) in the renal cortex were measured. ResultsCompared with DDP, TMP (50 and 100 mg8226;kg－18226;d－1) dosedependently reduced 24 h urinary protein, BUN and SCr induced by cisplatin, by 41.45%,65.33%;18.12%,57.51%;14.39%,48.89%（P＜0.05, P＜0.01）, respectively. The 100 mg8226;kg－18226;d－1 TMP significantly decreased levels of MDA, NO, NOS and GSH, SOD,GST induced by cisplatin in kidney by 36.73%, 45.39%, 22.86%( P＜0.05) , respectively; while, the content of GSH was increased by 1.33fold，1.66fold ,1.57fold （P＜0.05）, respectively, compared with that in the DDP group. ConclusionTMP could protect cisplatininduced oxidative nephrotoxicity.