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    药物研究
  • 药物研究
    Effect of the Aqueous Extract of Salvia Miltiorrhiza Bge on the Tolerance to Hypoxia in Mice
    GAO Yunsheng;CAO Guangchao;WANG Xiaodan;QI Yongxiu;ZHANG Jiguo;ZHU Yuyun
    2006, 25(10): 975-0976.
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    To study the effect of the aqueous extract of Salvia miltiorrhiza bge on the tolerance to hypoxia in mice. MethodsFifty mice of the Kunming strain were randomly divided into five groups. Mice of the low，medium and high dose drug treatment group were given each 10，20 and 40 g·kg1 of the aqueous extract of Salvia miltiorrhiza bge，respectively，administered by gastrogavage. Animals of the positive control group and blank control group were given each 20 mg·kg1 of propranolol and an equivalent volume of 0.9% sodium chloride solution via the same route，respectively. 40 min later the mice were subjected to normobaric hypoxia in an experimental device. The survival time and the amount of oxygen consumption of the animals were registered. ResultsThe survival time was obviously prolonged and the oxygen consumption sharply reduced in mice of the low，medium and high dose drug treatment groups. ConclusionThe aqueous extract of Salvia miltiorrhiza bge was shown to have a remarkable enhancing effect on the tolerance to hypoxia in mice.
  • 药物研究
    The Use of a Pharmacodynamic Method for the Assay of Pharmacokinetic Parameters of Chuanxiong Rhizome Volatile Oil Administered by Nasal Drip in Rats
    PAN Jia;PAN Xiaojuan;ZHANG Baijia;LIU Yaou;ZOU Wenjun
    2006, 25(10): 977-0979.
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    To assay the pharmacokinetic parameters of chuanxiong rhizome volatile oil administered by nasal drip with the use of a pharmacodynamic method in rats. Methods50 SD rats serving as the subjects of the study were randomly divided into 5 equal groups. The pain threshold of the animals was determined with the tailflick method described by H.G Vogel. 107，54，36，27 mg·kg1 of chuanxiong rhizome volatile oil and an equivalent amount of 0.9% sodium chloride solution was given to each rat of the 5 corresponding groups,respectively administered by nasal drip. The analgesic effect of the drug reflected by an increase in pain threshold in each animal of the 5 groups 15 min，30 min，45 min，1 h，2 h，3 h，4 h，6 h and 11 h after the nasal medication was determined for the assay of pharmacokinetic parameters of the drug. ResultsThe pharmacokinetic parameter determined were as follows：Dmin＝1.101 mg·kg1，β＝0.378 6 h1，t1/2（β）＝1.830 4 h，Kα＝21.536 5 h1，t1/2（Kα）＝0.032 2 h，α＝9.511 6 h1，t1/2（α）＝0.072 9 h，t max ＝0.739 h. ConclusionIt was quick for the chuanxiong rhizome volatile oil to reach its peak concentration in the body of the rat. The drug was promptly absorbed and the time for the drug to start up its effect was short.
  • 药物研究
    Antibacterial Effects of Origanum Volatile Oil on Dysentery Bacilli in Vivo and in Vitro
    LIAO Fang;HUANG Qinghua;YANG Zhende;XU Hanlin;GAO Qinghua
    2006, 25(10): 980-0983.
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    To survey the bacteriostatic and bacteriocidal effects of origanum volatile oil (OVI) on dysentery bacilli. MethodsMice were infected with Shigella sonnei;and Shigella flexneri F2a by intraabdominal inoculation of the bacteria. The protective effect of OVI administered by gastrogavage at different times after the infection on the mice were kept under observation. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC)of the drug for the dysentery bacilli were determined in vitro. ResultsThe OVI was shown to have an obvious protective effects on the mice infected with Shigella sonnei and Shigella flexneri F2a . The drug was also shown to have dramatic bacteriostatic and bacteriocidal effects on different dysentery bacilli in vitro. The MIC and MBC of OVI for dysentry bacilli were 50－100 mg·mL1 and 125－500 mg·mL1，respectively. ConclusionThe OVI was shown to be an effective medicine against infection of dysentery bacilli.
  • 药物研究
    Effect of Nimodipine on the Expression of Heat Shock Protein 70 (Hsp70) in the Tissue around an Intracerebral Hematoma in Rats
    CHANG SuJie;YIN Lin;QIU Xiaofeng;XIN Shimeng
    2006, 25(10): 984-0987.
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    To study the effect of nimodipine on the expression of Hsp70 in the tissue around an intracerebral hematoma(ICH) in rats so as to probe into the protective action of the drug on the ischemic brain tissue around the ICH.Methods120 healthy male SD rats were randomly divided into 3 groups：① the sham operation group(n＝20)，②ICH treatment group (n＝50) and ③ICH model group (n＝50).For each of the rats in groups ②and ③ an ICH model was established by injecting 50 μL of autoblood taken from the animal's femoral artery into the right caudate nucleus. In rats of the sham operation group(group ①)，needle was inserted into the same region as mentioned but no blood was injected. After the operation，rats of each of 3 groups were further divided into 5 equal subgroups scheduled for corresponding experimentations to be carried out 6，24，48，72 and 120 hours later. Immediately after the establishment of the ICH model，rats of the treatment group (group② ) were given each an intraperitoneal injection of 1.6 mg·kg1 of nimodipine followed by the same injection q.d.. Rats of the model group(group ③) were given each an equivalent amount of 0.9% sodium chloride solution via the same route. Nerve defect scoring was performed by a “blind” collaborator according to the method described by Bederson after the animals with the model awoke from the anesthesia. Animals of the ICH treatment group and model group with scores greater than 2 or equal to 2，reflecting a successful establishment of the model，were admitted into the experiment while all of the rats in the sham operation group were admitted. The admitted animals in each of the 15 subgroups described above were anesthetized with chloral hydrate and subjected to cardiac perfusion with 200 mL of 0.9%sodium chloride solution per rat followed by prompt decapitation for taking brain specimens 6，24，48，72 and 120 hours after the establishment of the model，respectively. Coronal sections across the caudate nucleus were made for the determination of the brain water content and assay of the expression of Hsp70 with the immunohistochemical method. Results①Brain water content： No apparent change was shown in the water content of the brain in rats of the model group 6h after the ICH. However，the water content began to increase 24h afterwards and reached its peak at 48－72 h，and then gradually declined. Dynamic changes in the brain water content in rats of the ICH treatment group followed a pattern similar to that in rats of the model group but the values at the different time points were lower(P＜0.05) .The values of the brain water content in rats of the model group and ICH treatment group were by and large greater than those in rats of the sham operation group.②Expression of Hsp70 in the brain tissue around the ICH： A few cells expressing Hsp70 were seen in the specimen from rats of the sham operation group throughout the period from 6 h to 5 d. Cells expressing Hsp70 in the brain tissue began to appear 6 h after the establishment of the ICH model，reached the peak 24－48 h thereafter and remained at high level until 120h in rats of both the model group and ICH treatment group. However，the values obtained from rats of the latter group were significantly greater than those obtained from rats of the former group(P＜0.01). The numbers of Hsp70 expressing cells in the brain tissues from rats of he model group and ICH treatment group were also strikingly greater than those from rats of the sham operation group(P＜0.01). ConclusionIncreased number of cells expressing Hsp70 after ICH may be related to the injury of the brain tissue around the hematoma. Increased expression of Hsp70 induced by nimodipine decreased the level of apoptosis around the hematoma，thus bringing about a protective effect on the nerve cells. Decreased content of brain water in rats treated with nimodipine suggests that the drug may also alleviate brain edema.
  • 药物研究
    Protective Effect of Magnesium Sulfate on the Spinal Cord Subjected to Acute Injury in Rats
    ZHOU Song;LIU Tie;ZHANG Fan;HU Weihua;CHEN Chao;LI Feng
    2006, 25(10): 988-0990.
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    To study the protective effect of magnesium sulfate (MgSO4)on the spinal cord subjected to acute injury in rats. Methods48 adult SD rats were randomly divided into 4 equal groups： group A (model group)，group B (treated with low dose MgSO4)，group C (treated with medium dose MgSO4) and group D(treated with high dose MgSO4).The model of a crash injury of the spinal cord at the level of T911 was established in each animals of the 4 groups according to the method described Allen. Directly after the establishment of the crash injury model，rats of the group B，C and D were given each an intraperitoneal injection of 100，300 and 600 mg·kg1 of MgSO4 solution，respectively. Animals of the model group were given each an intraperitoneal injection of an equivalent volume of 0.9% sodium chloride solution. 4 rats of each group were sacrificed 8，24 and 72 h later and the spinal cord of each animal was taken for the determination of the content of malonyldialdehyde (MDA) and activity of superoxide dismutase(SOD) as well as for histopathological examination. ResultsThe differences between the MDA content，SOD activities and apoptosis in the spinal cords taken from rats of the model group(group A)and low dose MgSO4 group (group B) were not significant(P＞0.05). However，the MDA contents were much lower and the SOD activities strikingly higher in the spinal cords from rats of the medium dose MgSO4 group(group C) and high dose MgSO4 group(group D) as compared with those indices from rats of the model group，the differences being significant(P＜0.05) or highly significant(P＜0.01). Along with the progress of time，the aptoptosis indices in the spinal cords from rats of the 4 groups were shown to increase. However，the larger the doses of MgSO4 administered，the smaller the increases in the apoptotic indices. ConclusionMagnesium sulfate was shown to exert protective effects on the spinal cord subjected to a crash injury in rats in a dose dependent manner.
  • 药物研究
    Effect of Taizhi’an Capsules on the Model of Liver Fibrosis Induced by CCl4 in Rats
    TONG Qiaoxia;WU Yanyan
    2006, 25(10): 991-0994.
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    To probe into the effect of taizhi’an capsules on the model of liver fibrosis in rats. Methods55 male SD rats were randomly divided into 3 groups： the control group(n＝15)，model group(n＝20) and treatment group(n＝20) . The model of liver fibrosis in rats of the model group and treatment group was established by subcutaneous injections of 3 mL·kg1 of 40% CCl4 per rat twice a week for 12 consecutive weeks. After the establishment of the model，rats of the treatment group were given each 1 g·kg1 of taizhi’an saline suspension(0.1 g·mL1) administered by gastrogavage q.d. for 8 consecutive weeks. Rats of the model group were given each equivalent volumes of 0.9 % sodium chloride solution via the same route as described. At the termination of the 8 week treatment course，blood samples and liver tissue were collected .Contents of malonyldialdehyde (MDA)，nitric oxide(NO) and activities of nitric oxide synthase(NOS) in the serum and liver homogenate were determined. The level of collagenous fibers in the liver tissue was assayed with the Van Gieson staining. The expressions of the transforming growth factor beta 1(TGFβ1),plateletderived growth factor(PDGF) and tissue inhibitor of metalloproteinase1(TIMP1) in the liver tissue were detected with immunohistochemiscal methods. ResultsTaizhi’an was shown to alleviate the histopathological changes of the liver and downregulate the expression of collagenous fibers and TIMP1 in the liver tissue from rats with liver fibrosis. During the course of the liver fibrosis，the contents of MDA，NO and the expression of NOS in the serum and liver homogenate were increased and the expression of TGFβ1 and PDGF in the liver tissue was upregulated. In the present study，taizhi’an was shown to strikingly decrease the contents of MDA and NO，inhibit the expression of NOS，TGFβ1 and PDGF in the liver tissue(P＜0.01) .ConclusionTaizhi’an was shown to exert therapeutic effects on the liver fibrosis induced by CCl4 in rats，probably by decreasing the contents of MDA and NO，and inhibiting the expressions of NOS，TGFβ1 and PDGF in the liver tissue.
  • 药物研究
    An Experimental Study of the Prevention of Liver Fibrosis by Amiloride Combined with Oxymoron
    ZENG Youxiang;YANG Weifeng;LIU Lingyun
    2006, 25(10): 995-0997.
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    To study the prevention of experimental liver fibrosis by amiloride combined with oxymoron. Methods40 male SD rats were randomly divided into 6 groups： the blank control group(n＝5)，model group(n＝7)，amiloride(Am) group (n＝7)，oxymoron(Ox) group(n＝7)，Am＋Ox group(n＝7) and positive control group(n＝7). Except for rats of the blank control group，those of the other 5 groups were given each an intraperitoneal injection of 10 mg·kg1 of dimethylnitrosamine (DMN) for 3 consecutive days in a week，and the course of injection lasted 3 weeks with the aim of the induction of liver fibrosis. During the course of induction，rats of the Am group were given each 1 mg·kg1 of Am，those of the Ox group were given each 500 mg·kg1 of Ox，and those of the Am＋Ox group were given each 1 mg·kg1 of Am and 500 mg·kg1 of Ox，respectively，administered by gastrogavage q.d.. The course of the drug treatment lasted 3 weeks. Rats of the positive control group were given each 90 mg·kg1 of malotilate ,q.d.,administered by gastrogavage for 3 consecutive weeks. Animals of the blank control group were given each an intraperitoneal injection of an equivalent volume of 0.9% sodium chloride solution ,q.d., for 3 consecutive days in a week and the course of injection lasted 3 weeks. Meanwhile，these rats were given each an equivalent volume of 0.9% sodium chloride solution administered by gastrogavage q.d. for 3 weeks. Ratios of liver weight/body weight，spleen weight/body weight were calculated. Levels of serum albumin(A)，globulin(G)，alanine aminotransferase(ALT)，alkaline phasphatase(AKP)，hyaluronic acid(HA)，laminin(LN)and contents or activities of malonyldialdehyde(MDA)，glutathione peroxidase(GSHPX)，superoxide dismutase(SOD)and hydroxyproline(HYP) of the liver tissue were determined. ResultsActivities of serum ALT and AKP in rats of the Ox group and Am＋Ox group were significantly decreased(P＜0.01)，while ratios of serum A/G in rats of these 2 groups were increased after the treatment (P＜0.01)as compared with those in rats of the model group. Contents of serum HA and LN as well as the level of liver HYP were decreased in rats of the Am group and Ox group after the treatment as compared with those in rats of the model group(P＜0.05 or P＜0.01). Activities of SOD and GSHPX of the liver in rats of the 4 drugtreated groups were significantly higher while the contents of MDA were strikingly lower than those in rats of the model group after the treatment(P＜0.01). The best preventive effects were shown in rats of the Am＋Ox group. ConclusionBoth amiloride and oxymoron were shown to have preventive effects on liver fibrosis induced by DMN in rats. Combined application of the 2 drugs exerted a definite synergetic effect.
    • 药物与临床
  • 药物与临床
    A Study of the Radiosensitizing Effect of Lowdose Navelbine in the Treatment of Locally Advanced Nonsmall Cell Cancer of the Lung
    ZHOU Chenhua;DENG Qinghua;MA Shenglin;CHEN Yong;YE Hong;WANG Baoqiang
    2006, 25(10): 1011-1012.
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    To probe into the radiosensitizing effect and adverse reactions of lowdose navelbine(NVB) in the treatment of locally advanced nonsmall cell cancer of the lung（NSCLC）. Methods60 patients with locally advanced NSCLC were randomly divided into two equal groups，the trial group and control group. Prior to radiotherapy，patients of both groups were subjected to 2 cycles of induction chemotherapy each of which lasting 3 weeks. In each of the 2 cycles，the patients were given each 25 mg·(m2)1 of NVB on day 1 and 8，30 mg·(m2)1 of cisplatin from the 1st to 3rd day，according to the NP program. The radiotherapy was started up 2 weeks after the termination of the 2nd cycle of induction chemotheraphy. Routine fractionation method was used. The patients were given each a total dose of 6－15 MVX ray DT 60 Gy divided into 30 fractionations administered successively in a period of 6 weeks. During the course of radiotherapy，patients of the trial group were given each additionally 6 mg·(m2)1 of NVB on each Tuesday and Thursday. One week after the termination of ratiotherapy，patients of both groups were once more subjected to 2 cycles of induction chemotheraphy according to the NP program. ResultsShortterm therapeutic effectiveness： the rates of complete remission and partial remission as well as the overall effective rates in patients of the trial group and control group were 13.3%，60.0% and 73%，and 10.0%，56.7% and 66.7%，respectively，the differences between the 2 groups being significant(P＜0.05). The 1，2 and 3 year survival rates in patients of the trial group and control group were 66.3%，36.7% and 23.3%，and 46.7%，26.7% and 16.6%，respectively，the differences between the 2 groups being insignificant(P＞0.05) . ConclusionLowdose navelbine was shown to have radiosensitizing effects in the treatment of patients with locally advanced NSCLC，but it could not increase the survival rate of the patients.
  • 药物与临床
    Clinical Therapeutic Effects of Edaravone Injection in the Treatment of Acute Cerebral Hemorrhage
    LI Gang;YUAN Guanglei;CHEN Wei;MEI Yuanwu;TONG Etang
    2006, 25(10): 1013-1015.
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    To study the clinical therapeutic effects of edaravone injection in the treatment of acute cerebral hemorrhage. Methods50 patients with acute cerebral hemorrhage according with the diagnostic criteria were randomly divided into 2 equal groups： the trial group and control group. Osmotic diuretics，antihypertensives，antidiabetics，brain cell activators and remedies for symptomatic treatment in different doses were used in patients of the control group according to the extent of the cerebral hemorrhage. On the basis of these managements，patients of the trial group were given each 30 mg of edaravone dissolved in 250 mL of 0.9% sodium chloride solution administered by intravenous instillation b.i.d. for 14 consecutive days. Scoring of the nervous function defect and assessment of the therapeutic effectiveness in patients of both groups were carried out 7，14 and 28 days，respectively，after the termination of the treatment course with the use of the Chinese Stroke Scale (CSS). ResultsIn patients of the trial group，the CSS scoring of 19.6±8.7 before the treatment fell to a low value of 11.8±4.6(P＜0.01) 28 days after the termination of the treatment. In patients of the control group，the pretreatment CSS scoring of 20.5±9.6 dropped to a posttreatment value of 15.4±6.3 (P＜0. 05) 28 days after the termination of the treatment. The posttreatment CSS scoring in patients of the trial group was significantly lower than that in patients of the control group (P＜0. 05). No major adverse reactions were encountered in patients of the trial group. ConclusionEdaravone was shown to effectively improve the nervous function in patients with acute cerebral hemorrhage.
  • 药物与临床
    Effects of Retention Enema with Traditional Chinese Medicines in the Treatment of Ulcerative Colitis：A Systematic Appraisal
    JIANG Ting;XIA Bing;LI Chun;LUO Yan
    2006, 25(10): 1016-1018.
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    To assess the therapeutic effectiveness of retention enema with traditional Chinese medicines in the treatment of ulcerative colitis. MethodsAccording to the method provided by the international Cochrane Coordination Net, the randomized controlled trials (RCTs) concerning the retention enema treatment of ulcerative colitis with the traditional Chinese medicines were subjected to a systematic appraisal. An electronic search of the Excerpta Medica Database (EMBASE)，Chinese Biomedical Database(CBMdisc) and Chinese National Knowledge Infrastruc of ture(CNKI)(19952005)，as well as a manual search of published and unpublished literatures was carried out for the inclusion of the data into RCTs for the comporison between traditional Chinese medicines and routine Western medicines in the treatment of the disease . The Rev Man 4.2 software of the Cochrane Coordination Net was used for Statistical analysis.ResultsA total of 23 RCTs were included in the study. The results of shortterm effects showed that enema with traditional Chinese medicine was by and large superior to Western medicine. Metaanalysis of 8 RCTs indicated that the clinical effective rate of enema with traditional Chinese medicine was 92.8%(337/363)，while that of oral sulfasalazine(SASP) was 89.9%(222/247). Metaanalysis of 3 RCTs revealed that the effective rate of enema with traditional Chinese medicines was 93.1%(122/131)，and that of enema with glucocorticoid ＋gentamicin was 71.6%(68/95). Metaanalysis of 4 RCTs showed that the effective rate of enema with traditional Chinese medicines was 94.2%(260/276)，while that of oral sulfasalazine＋glucocorticoid was 74.9%(125/167).No major adverse reactions were encountered in patients treated with enema with traditional Chinese medicines. ConclusionThe methods adopted in the present study were of relatively low quality. Although retention enema with traditional Chinese medicines was shown to be superior to routine treatment with Western medicines in the case of shortterm effect，no definite conclusion，however，could be drawn from the results of the present study owing to the lack of methods for the assessments of longterm effects.
  • 药物与临床
    Effect of Vitamin C on the Function of Vascular Endothelium in Patients with Type Ⅱ Diabetes Mellitus
    XIANG Guang-da;HAN Fang;ZHAO Lin-shuang;HOU Jie;LE Ling
    2006, 25(10): 1019-1022.
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    To probe into the protective effect of vitamin C on the function of vascular endothelium in patients with Type Ⅱdiabetes mellitus.Methods30 patients with newly diagnosed Type Ⅱ diabetes mellitus were randomly divided into two equal groups: the treatment group and the control group. Patients of the control group were subjected to combined intervention therapy including diabetic diet, regular aerobic exercise and insulin. On the basis of these measures, patients of the treatment group were given each 0.1 g of vitamin C PO, t.i.d.. The course of treatment in both groups lasted 6 months. 14 healthy individuals served as normal controls. The endothelium- dependent arterial dilation (EDD) mediated by the brachial arterial blood flow and endothelium- independent arterial dilation mediated by nitroglycerin were measured with the high resolution extravascular ultrasound technique before and after the intervention therapy. ResultsIn comparison with the normal controls, the Type Ⅱ diabetics had significantly higher levels of fasting blood glucose(FBG),2h postprandial blood glucose(2h PG),serum total cholesterol(TC) and triglycerides(TG) before and after the intervention therapy (P < 0.05 or P < 0.01). In the patients with Type Ⅱ diabetes , the level of serum low density lipoprotein-cholesterol(LDL-C) was significantly higher (P < 0.05), while that of high density lipoprotein-cholesterol(HDL-C) was apparently lower(P<0.05) than those of the normal controls before the treatment. The serum levels of HbA1C, FBG, 2 h PG, TC,TG and LDL-C in patients of both the treatment group and control group after the treatment were significantly lower than those before the treatment (P < 0.05 or P < 0.01). The EDD in patients with Type Ⅱ diabetes was significantly lower than that in normal controls(P < 0.05 or P< 0.01). The EDD in patients of both the treatment group and control group was strikingly improved after the treatment (P < 0.01). Moreover, the EDD after the treatment in patients of the treatment group was significantly higher than that in patients of the control group (P < 0.05). ConclusionVitamin C was shown to apparently improve the vascular endothelial function in patients with Type Ⅱ diabetes.
  • 药物与临床
    Treatment of 41 Cases of AIDS with Antiretrovirals
    YANG Rong-rong;GUI Xi-en;ZHANG Yong-xi;FU Xue-dong
    2006, 25(10): 1023-1024.
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    To survey the therapeutic effectiveness of two nucleoside-inhibitors plus one non-nucleoside-inhibitor of reverse transcriptase in the treatment of patients with acquired immuro deficiency syndrome(AIDS). Methods41 patients with AIDS were subjected to the medication carried out strictly according to the directions. The course of treatment lasted 21.2 months in adults and 16.6 months in children. The patients were followed up at regular intervals. Improvement in symptoms was kept under observation. CD4+ lymphocyte counts and viral load(VL) were measured. Adverse drug reactions were closely monitored and corresponding measures were taken if any of these reactions were encountered. For those patients with unsatisfactory curative effects, drug resistance analyses at the genome level were carried out.ResultsDuring the course of treatment, none of the patients died. The incidence of opportunistic infections dropped from 56.1% before the treatment to 9.8% after the treatment. The viral load was decreased to below the detection level along with the increase in the counts and percentages of CD4+ lymphocytes. In 4 patients the CD4+ counts were shown to decrease again after an increase in a period of time and the viral load rose to levels above the detection limit. In the mean time they suffered opportunistic infections. Besides, the HIV in 2 patients was demonstrated to have acquired drug resistance as revealed by the drug resistance analysis at the genome level. The adverse reactions encountered were: 4 cases of skin rash from mild to moderate degree, 2 cases of generalized eruption, 9 cases of peripheral neuritis, 7 cases of abnormal liver function and 1 case of severe anemia that responded well to the treatment with recombinant human erythropoietin(rHuEPO). Conclusion The antivirals provided free of charge by the State was shown to be fairly effective in the treatment of patients with AIDS . The treatment plan should be timely readjusted in patients manifesting severe adverse reactions. Patients with not very severe adverse reactions should be encouraged to insist on further treatment associated with symptomatic managements. The prophylaxis and treatment of AIDS have to face new challenges owing to the appearance of drug resistant HIV variants.
    • 药物制剂
  • 药物制剂
    A Study of the Composition of the Ground Substance and the Preparation Technology of a Radioprotective Ointment
    YANG Anping;TAN Changqing;WANG Zongwei
    2006, 25(10): 1047-1048.
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    To probe into the composition of the ground substance and preparation technology of the radioprotectant(RPA )ointment . MethodsThe delamination time of the RPA ointment during heating was adopted as the trial index for screening of the composition of the ground substance and the emulsification temperature of the drug with an orthogonal design. ResultsThe optimal composition of the ground substance of the RPA ointment was shown to be as follows: stearic acid 12.5 g，liquid paraffin 12.5 g，triethanolamine 0.5 g，glycerine 8.0 g，Tween80 2.0 g，and the optimal emulsification temperature was 75 ℃. ConclusionRPA ointment of stable quality could be prepared by adopting the optimal composition of the ground substance and optimal emulsification temperature confirmed in the present study.
  • 药物制剂
    Preparation and Quality Control of Sodium New Houttuyfonate Eyedrops
    WANG Haibo;YI Yimu
    2006, 25(10): 1049-1050.
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    To prepare a new kind of sodium new houttuyfonate eyedrops and to control its quality. MethodsIn the preparation of the sodium new houttuyfonate eyedrops，sodium new houttuyfonate served as the basic remedy while polysorbate 80 and sodium dihydrogen phosphate etc. were used as adjuvants. The content of the basic remedy in the preparation was determined with HPLC，and the quality control of the eyedrops was carried out according to the Pharmacopoeia of the People’s Republic of China. Results The eyedrops prepared was shown to be stable in quality and accurate in the content of the basic remedy. The average rate of recovery was 100.21%，RSD＝0.48(n＝9). ConclusionThe formula of the preparation was rational，the technology of preparation was simple，and its content determination was quick and accurate.
    • 药品质量控制
  • 药品质量控制
    Identifieation of the Components of Kangfuyan Capsules with Thin Layer Chromatography
    LIU Yaru;MENG Xiansheng;FENG Xuesong
    2006, 25(10): 1053-1054.
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    To set up a method for the quality identification of kangfuyan capsules. MethodsThin layer chromatography(TLC) was used for the identification of the 5 traditional Chinese medicines in the kanfuyan capsules： Rhizoma Atractylodis，Radix Angelicae Sinensis，Rhizoma Ligustici Chuanxiong，Rhizoma Cyperi and Rhizoma Corydalis. ResultsThe spots of the 5 traditional Chinese medicines to be identified in the TLC were clearcut and easily recognizable. ConclusionThe method was shown to be handy and accurate，and may be used for the quality identification of kangfuyan capsules.
  • 药品质量控制
    Establishment of a Gas Chromatographic Fingerprint Spectrum of the Traditional Chinese Medicine Cortex Magnoliae Officinalis
    XIANG Yi;QI Zhi;GUO Min;MA Changqing;ZHOU Mojiong;YAO Pei;YU Qingsong
    2006, 25(10): 1055-1056.
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    To set up a method for the crude drug fingerprint spectrum analysis of the chemical constituents in Cortex Magnoliae Officinalis so as to provide basis for the identification of the drug. MethodsSteam distillation method was used to extract volatile oil components from the crude drugs of Cortex Magnoliae Officinalis obtained from different sources. The fingerprint spectrum of the extracts were assayed with capillary gas chromatography and compared with the cluster analysis method. ResultsDrug samples of Cortex Magnoliae Officinalis from 10 different sources were divided into two kinds： 9 samples showed degrees of similarity between 0.9－1.0，while 1 sample had a degree of similarity below 0.9. ConclusionThis method was shown to have high sensitivity and good reproducibility and the cluster analysis method made the spectrum analysis faster and more accurate，and is thus suitable for the quality identification of Cortex Magnoliae Officinalis.
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