中国科技论文统计源期刊 中文核心期刊
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
To study the behavior and pathology changes characteristic to Alzheimer's disease(AD) in rats induced by high
concentration zinc in cerebrospinal fluid. MethodsZinc chloride was injected into the rats' cerebral ventricles. Behavioral tests were
performed in the Morri's water maze (MWM). The apoptotic cells were tested by flow cytometry. Immunocytochemical staining was used
to show the pathology of βamyloid plaques. Pathology changes at cellular level were examined under transmission electron microscope
(TEM). ResultsThere was obvious behavior damage in zinc treated rats, and there were more apoptosis in zinc treated rats. βamyloid
plaques were interspersedly distributed in extensive area of cerebral cortex and hippocampus. Karyolysis and derangement of
microtubules was seen in zinc treated rats.ConclusionHigh concentration of zinc in brain tissue may result in abnormal intelligence and
pathology changes characteristic to AD.
To study the effect of water extract from herba
leonuri on the contraction of rabbit aorta smooth muscle. MethodsThe influences of water extract from herba leonuri on the doseeffect
curve of norepinephrine (NE), potassium chloride (KCl) and calcium chloride (CaCl2) were observed on the isolated aortic strips of rabbits.
ResultsTo the doseeffect curve of NE, 25 mg·mL1 water extract from herba leonuri worked as a agonist and the highest response
increased was (6±4)%, 50 mg·mL1 and 75 mg·mL1 of the extrat worked as partial agonists. To the doseeffect curve of KCl and of
CaCl2, 25 mg·mL-1and 50 mg·mL1 of the extract worked as partial agonists, respectively.Conclusion The contraction on the vascular
smooth muscle by water extract from herba leonuri were related to the concentration of the extract, the higher concentration might
mainly block potentialdependent calcium channel and the lower concentration might mainly block receptoroperating calcium
channel.
To study the effect of qingkailing(QKL) injection in counteraction of E.
Coli O111B4 endotoxin. Method The antiendotoxin effect of QKL injection were studied by determination of bacterial endotoxin and by
pyrogen test in rabbits. ResultsEven if being diluted for 16 mutiples, QKL injection could destroy equal volume of endotoxin (10 EU·mL1).
When the endotoxin injection was administered by iv following QKL (2 mL·kg1), only a slight fever was induced in the rabbits while
obvious fever presented in the group without receiving QKL injection. ConclusionQKL injection had the effect counteracting endotoxin of
E.Coli O111B4.
To evaluate the effect of irbesartan to
maintain sinus rhythm in patients with durative atrial fibrillation after cardioversion. MethodsFiftytwo patients with durative atrial
fibrillation were randomized into two equal groups. Group I were treated with amiodarone, and group Ⅱ were treated with amiodarone
plus irbesartan. The reoccurence of atrial fibrillation was observed in all the patients for 6 mo after cardioversion. ResultsThe reoccurence
of atrial fibrillation in group I was higher than that in group Ⅱ. ConclusionThe results suggest that irbesartan may reduce the reoccurrence
of atrial fibrillation and be efficacious in maintaining sinus rhythm.
To observe the effect of doxazosin on blood pressure, plasma calcitonin
generelated peptide (CGRP) and endothelin (ET) concentration in patients with mild to moderate essential hypertension. MethodsA
randomized, double blind study was carried out on fourtyeight patients with stage 1 or stage 2 essential hypertension. The patients were
randmised into doxazosin group and terazosin group. The levels of plasma ET and CGRP were dermined by radioimmunoassay methods
before and after treatment. ResultsAfter 8 wk treatment, the effective rate of the bloodpressure control in doxazosin group and in
terazosin group were 83.5% and 78.3%. No significant difference was found between the two groups ( P＞0.05). TC levels in doxazosin
group were lower significantly after the treatment than before treatment (P＜0.05). The plasma ET for both experimental groups were
significantly decreased (P＜0.01) and plasma CGRP levels were significantly increased in both groups (P＜0.01), and there was no
significant difference between the two groups ( P＞0.05). ConclusionDoxazosin is an effective antihypotension drug. It can also lower the
plasma TC level. Its antihypertension effect may relate to the decreasing of plasma ET and the increasing of the plasma CGRP.
