药物研究
WANG Jinrong;HAN Xiuzhen;WANG Hongwei;CHENG Peixuan;HAN Bo
2004, 23(3): 135-0137.
To explore the effect of hydroxychloroquine (HCQ) on the synovial histology of adjuvant arthritis in rats. Methods:Eihgtyeight Wistar rats were devided into 5 groups randomly: A, B, C, D, E, with 24 in group B and 16 in each of the other four groups. Group A were the untreated, injected with 0.1 mL sodium chloride injection, adjuvant arthritis (AA) models were firstly induced by intradermal injection with the complete adjuvant in the right footpad to the other four groups. Group B were the controls, no more treated. All the drugs were fed 21 days later. C, D, E groups were all fed with naproxen 5 mg·kg1·d1 for 1 month. Group C were added with HCQ 4 mg·kg1·d1 for 5 months, and the D with prednisone 2 mg·kg1·d1 for 1 month, succeeded with prednisone 1 mg·kg1·d1 for another 4 months. The therapeutic effects were measured by diameter of right posterior ankle joint from left to right, the volume of right posterior paw, arthral histopathologic change and the ultrastructure of synovium and the calculating scores. Results:Four weeks later the scores in group D with prednisone were lower than the group C with HCQ，but there were no significant difference between the two groups (P＞0.05), both group scores significantly lower than the control group(P＜0.01). Twenty weeks later, the signs measured and the histopathologic scores of synovium in HCQ group and prednisone group were almost normal, both were significantly improved than the controls and the naproxen group (P＜0.01). There was no difference in HCQ group and prednisone group(P＞0.05), but group C has less sideeffects.Conclusions:Hydroxychloroquine can improve the ultrastructure of synovial cells, reduce synovial inflammation significantly and with less sideeffects comparatively. Hydroxychloroquine is an ideal and effective antirheumatic drug.
