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    药物研究
  • 药物研究
    Protective Effects of Chlorpromazine on Rat Neurons Injured by Glutamate in Vitro
    YI Quan;LIANG Jian;ZHANG Genshui;OU Huijian
    2003, 22(2): 75-77.
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    Objective:To study the effect of chlorpromazine (CPZ) on glutamateinduced neurotoxicity in rat primary cultures of cerebral cortical neurons. Methods:The effects of drugs glutamate (Glu) and CPZ on neuron morphology were surveyed with the inverted microscope. Trypan blue exclusion method was used to assess the neuronal viability. Assay of lactate dehydrogenase(LDH) in the supernatant served to represent the extent of neuron injury. Results:50 μmol•L1 Glu enhanced the death of neurons with a corresponding 351% increase in LDH release. 1, 10 μmol•L1 CPZ was found to reduce neuron death rate and LDH release induced by Glu and the condition of neuron growth was improved. Conclusion:CPZ was shown to have an obvious protective effect on rat cerebral cortical neurons exposed to the neurotoxic agent Glu.
  • 药物研究
    Effects of Different Preparations of Naoan Capsules on Platelet Aggregation in the Rat
    ZHANG Xujing;FAN Liu;WANG Suchun;FENG Chunhong;WANG Chunan;WANG Guiqing
    2003, 22(2): 77-79.
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    Objective:To study the effect of two different preparations of Naoan capsules the modified as well as traditional type on platelet aggregation in the rat. Methods:60 rats were randomly divided into 6 groups, with 10 animals in each group. Rats of the 6 groups were fed different drugs administersed into the stomachs by peroral catheters q.d. for 3 consecutive days according to the following scheme: group A (blank control), rats were given 0.9% sodium chloride solution; group B; 40 mg•kg1•rats1(low dose) of modigied Naoan capsules; group C, 80 mg•kg1•rats1(high dose) of modified Naoan capsules; group D, 40 mg•kg1•rats1(low dose) of traditional Naoan capsules; group E, 80 mg•kg1•rats1 (high dose) of traditional Naoan capsules; group F, 300 mg•kg1•rats1 of aspirin. Blood samples were then taken taken from the rats for assey of platelet aggregation. Results:Modified Naoan capsules in high dose were shown to exert a much stronger inhibition of platelet aggregation than traditional Naoan capsules (P＜0.01). Both modified and traditional Naoan capsules were found to exert stronger inhibition of platelet aggregation than aspirin (P＜0.01, P＜0.05). Conclusion:Modified Naoan capsules were shown to exert a much stronger inhibition of platelet aggregation than traditional ones.
  • 药物研究
    A Study of the Effects of Herba Houttuyniae on the Antibacterial Activity of Penicillin G and Cefazolin
    CHEN Weibing;JIANG Caie;XIONG Nanyan;HAO Rui;WANG Yanfen
    2003, 22(2): 80-81.
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    Objective:To study the effects of herba houttuyniae on the in vivo antibacterial activitiy of penicillin G and cefazolin in rabbits. Methods:25 healthy rabbits were divided into 5 groups, with 5 animals each. The rabbits of group 1, 2, 3, 4 and 5 were given a daily IV injection of herba houttuyniae (1 mL•kg1), penicillin G (0.12 g•kg1), herba houttuyniae (1 mL•kg1) and penicillin G (0.12 g•kg1), cefazolin (0.07 g•kg1), herba houttuyniae (1 mL•kg1) and cefazolin (0.07 g•kg1), respectuely, for 6 consecutive days. 3 ml of blood were than taken from the marginal vein of each rabbit and the antibacterial activities of the sera were measured by microbiological methods. Results:Herba houttuyniae itself was shown to have little antibacterial activity in vitro and in vivo, but it did very significantly enhance the in vivo antibacterial activity of penicillin G(P＜0.01) . However, herba houttuyniae had no obvious influencon the antibacterial activity of cefazolin(P＞0.05). Conclusion:Herba houttuyniae in combination with penicillin G, but not with cefazolin, was shown to have a synergistic antibacterial activity.
    • 神经科用药专栏
  • 神经科用药专栏
    Clinical Application of Nimodipine in the Treatment of Acute Intracerebral Hemorrhage
    CAO Fei;SUN Shengang;TONG Etang;LUO Fang;WANG Jing
    2003, 22(2): 82-83.
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    Objective:To observe the clinical therapeutic effectiveness of nimodiping in acute intracerebral hemorrhage. Method:With the prospective random blind method,152 patients with acute intracerebral hemorrhage confirmed by CT scan were given treatment of pure mannitol or/and nimodipine after the hemorrhage onset. The two groups were compared with the indices of the different cores of neurological functional defect, the volume of hematoma and edema absorptive rate. Results:The average score of neurological functional defect and the absorptive rate of hematoma and edema with treatment of nimodipine were higher than those in the control group. Conclusion:Nimodipine is a safe and effective drug in the treatment of acute intracerebral hemorrhage.
  • 神经科用药专栏
    The Effect of Defibrase in the Treatment of 35 Patients with Progressive Cerebral Infarction
    WANG Tan;CHEN Zhibin
    2003, 22(2): 84-85.
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    Objective:To study the curative effect of defibrase in the treatment of patients with progressive cerebral infarction(CI). Methods:65 patients with progressive cerebral infarction were randomly divided into two groups. 35 patients of the treatment group received each 10 kU of defibrase on day 1 and 5 kU on day 3 and day 5 by i.v. instillation followed by a daily i.v. instillation of 80 mg of ozagrel sodium and 50 mg of aspirin p.o. until day 15 was reached. 30 patients of the control group were given each a daily i.v. instillation of ozagrel sodium and 50 mg of aspirin p.o. for 15 consecutive days. Appraisal of nervous function, determination of plasma fibrinogen and monitoring of changes in blood rheology were carried out before and after the treatment. Results:The rate of excellent curative effect and total effective rate were 74.3% and 82.9% in the treatment group, and 23.3% and 40.0% in the control group, respectively (P＜0.05). Conclusion:Defibrase was shown to have a striking effect in the treatment of progressive cerebral infarction.
  • 神经科用药专栏
    Pergolide in the Treatment of Very Old Patients with Parkinson’s Disease
    ZHANG Xuehong;SUN Bin
    2003, 22(2): 86-87.
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    Objective:To survey the therapeutic effectiveness and safety rate of pergolide mesylate in the treatment of very old patients with Parkinson’s disease(PD).Methods:A retrospective analysis was made for 10 very old patients with PD treated with pergolide mesylate on the basis of routine treatment. The daily dosage of pergolide mesylate was 25～250 μg given p.o. in 2 or 3 diveded doses. The course of treatment lasted 1.5～60 months. Results:The effective rate was 80.0% (8/10). The maintenance dose was 250～750 μg•d1. 4 of the 10 patients had slight adverse reactions, including commonly nausea and constipation. Conclusion:Pergolide was shown to have a fairly good therapentic effect in the treatment of very old patients with PD. Pergolide may be used in combination with artane, Amantadine and levodopa for augmenting the therapeutic effect.
  • 神经科用药专栏
    Metoclopramide in the Treatment of 40 Cases of Migraine
    LIU Jianguang;YAN Pingjian;LI Yaxin;JIANG Hongmei
    2003, 22(2): 88-89.
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    Objective:To evaluate the effect of intravenous metoclopramide in the treatment of migraine.Methods: 80 patients with migraine were randomly divided into 2 equal groups with 40 cases each. During an episode of migraine, patients of the treatment group were given each an i.v. injection of 10 mg of metoclopramide (2～5 mg•min1). In the meantime, patients of the control group were subjected each to a hypodermic injecting of 6 mg of sumatriptan. Results:The total effective rates were 77.5% and 80.0% in the treatment group and control group respectively. Within half an hour after medication, the effective rate of the treatment group was higher than that of the control group (P＜0.05). 4 hours after the treatment, the difference between the effective rates of the treatment group and the control group was insignificantly(P＞0.05).Conclusion:In the treatment of migraine, i.v. injection of metoclopramide was found to act quickly with definite therapeutic effectiveness.
  • 神经科用药专栏
    廖小平,杜艳芳,昌军,夏琳,李军
    2003, 22(2): 90-90.
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    • 药物与临床
  • 药物与临床
    Combined Application of Salbutamol and Ipratropium Bromide in the Treatment of Bronchial Asthma in Children
    NI Shufang;YAO Wenjiang
    2003, 22(2): 96-97.
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    Objective：To study the therapeutic effect of combined application of salbutamol and ipratropium bromide in the treatment of childhood bronchial asthma.Methods：141 children with bronchial asthma were randomly divided to three groups: A, B and C. Patients of group A(55 cases) were treatment with aerosol inhalation of salbutamol in combination with ipratropium bromide; patients of group B(48 cases), with aerosol inhalation of salbutamol alone and patients of group C (38 cases), with aerosol inhalation of ipratropium bromide alone. 0.25～1.0 mL of salbutamol or ipratropium bromide was diluted to 2 mL with 0.9% sodium chloride solution for nebulization, 2～4 times a day. Results： The rates of complete remission of symptoms were 72.2%, 45.8% and 42.1% in patients of group A, B and C, respectively. The therapeutic effect of group A patients was strikingly superior to that of group B as well as of group C patients (P＜0.01). Conclusion：Aerosol inhalation of salbutamol in combination with ipratropium bromide was shown to have a much better therapeutic effect in the treatment of childhood bronchial asthma as compared with lither drug used alone.
  • 药物与临床
    Green or Desensitizer in the Treatment of Dentine Hypersensitiveness: a Report of 40 Cases
    MA Jingzhi;GUO Sanlan;WANG Gang;YU Wenhui
    2003, 22(2): 97-98.
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    Objective：To appraise the therapeutic effectiveness of green or desensitizer in the treatment of dentine hyper sensitiveness.Methods：98 teeth with hypersensitive dentine 40 patients were treated with green or desensitizer. Solutions Ⅰ and Ⅱ were applied one after another for about 10 seconds each onto the area of hypersensitive dentine that had just been blowerdried. The treatment should be repeated in severe cases.Results：The total effective rate was 98.0%.Conclusion：Green or desensitizer was shown to be an effective drug in the treatment of dentine hypersensitiveness.
    • 药品质量控制
  • 药品质量控制
    Content Determination of Rutin in Huaihuasan (Sophora Powder) with HPLC
    YAO Guoxin;ZHANG Xiaoyan;ZHU Meiyan;ZHAO Zhiyan
    2003, 22(2): 115-116.
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    Objective:To set up a HPLC method for determining the content of rutin in Huaihuasan decoction. Method:A HypersilC18 column was used for separation. The mobile phase was composed of methanolwateracetic acid(40∶57.5∶2.5), the detection wavelength set at 254 nm. Results:A good linear relationship was found within the range of 12.1～1 210.0 μg•mL1 of rutin; the correlation coefficient was 0.999 89, and the RSD, 1.54%, The rates of recovery at high and low concentration were 100.18% and 99.20%, respectively. Conclusion:The method was shown to be simple convenient and feasible, and the results reliable.
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