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    特约稿
  • 特约稿
    Analysis on Consumption Structure and Clinical Usage of Drugs Used by SARS Inpatients in Xiaotangshan Hospital of PLA
    FENG Chaoying;WEI Rong;WANG Shu
    2003, 22(11): 751-753.
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    Objective:To analyze the comsumption structure and usage of drugs used by SARS inpatients at Xiaotangshan hospital. Method:The data of drugs used were collected from May 1 to June 20 in 2003. The first 25 drugs were arranged according to their quantity used. Results:Antiviral, glucocorticoid and antibacterial agents were the first 3 kinds of drugs used massively. The cost of glucocorticoid was the highest, which accounted for up to 17.51% of the total cost of all drugs. Conclusion:Drugs used in the treatment of SARS were specific, particular, and also comprehensive.
    • 药物研究
  • 药物研究
    Inhibitory Effects of 99TcMDP Injection on Bone Invasion by Walker256 Carcinoma in Rats
    CHEN Yingmao;ZHANG Jinming;TIAN Jiahe;YAO Shulin;DING Weimin
    2003, 22(11): 754-755.
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    Objective:To investigate the inhibitory effects of 99technetium methylenediphosphonate(99TcMDP) injection on bone invasion by walker 256 carcinoma in rats.Method:The experimental model of bone invasion by walker 256 carcinoma was made with 96 rats .The animals were divided into 6 groups, control group, 8 mg•kg1 bonefos group, and 1, 2, 4, 8 mg•kg1 99TcMDP groups. The rats were injected in abdominal cavity with the drug for 10 days and then were killed on the eleventh day. The tibias’ and tumor tissues’ weights, roentgenogram and histology were examined. Results:The tibias’ weight and the level of bone invasion by walker 256 carcinoma in 4, 8 mg•kg1 99TcMDP groups and bonefos group were significantly lower than those in the control group. The difference between the 99TcMDP group and bonefos group was not significant. The effect of 1 and 2 mg•kg1 99TcMDP did not significantly differ from the control.Conclusion:99TcMDP and bonefos can inhibit bone 99TcMDP increase with increasing doses.
  • 药物研究
    Protective Effects of Ornithine Aspartate on Liver
    JIN Jing;ZENG Fanbo;ZHOU Yan;CHENG Bo
    2003, 22(11): 756-757.
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    Objective:To testify the protective effects of ornithine aspartate on the liver. Method:Three models were made:the rat model of acute hepatic injury by CCl4, the mouse model of fatty liver by ethioine and mouse hypnosis induced by sodium pentobarbital.Results:The levels of the serum AST and pathological injury were significantly decreased in the CCl4 group. the increased triglyceride level induced by ethionine was lowered,and the sleeping time in the third model was shortened. All of the above effects were in correlation with drug dosage. Conclusion:Ornithine aspartate has significant protective effects on the liver.
  • 药物研究
    Antiarrhythmic Effect of Liensinine’s Derivatives
    YANG Jian;LUO Shunde;CHEN Yi
    2003, 22(11): 758-760.
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    Objective:To study the antiarrhythmic effects of four liensinine’s derivatives. Method:Experiments were performed in three arrhythmic animal models: ouabaininduced arrhythmia in guinea pigs, CaCl2induced and aconitineinduced arrhythmia in rats. Results:The four liensinine’s derivatives (5 mg•kg1, iv) could markedly increase the threshold dose of ventricular extrasystole (VE), ventricular tachycardia (VT), ventricular fibrillation (VF) and cardiac arrest (CA) caused by ouabain in guinea pigs and aconitine in rats; delay the oneset time of arrhythmia and shorten the recovering time of normal heart rate and mortality of CA caused by CaCl2 in rats.Conclusion:The four liensinine’s derivatives have extensive antiarrhythmic effects.
  • 药物研究
    Protective Effects of Ginkgo Biloba Leaf on Acute Renal Injury Caused by Aristolochia Manshuriensis Kom
    ZHU Shaoming;LIU Mingqiu;LIU Jiubo;CHEN Lin;WU Pingyong;YI Jianhua;WEI Guoyao;ZHU Liguo
    2003, 22(11): 760-762.
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    Objective:To study the mechanism of renal injury induced by aristolochia manshuriensis Kom and possible protective effects of ginkgo biloba leaf.Method:To divide the rats into three groups randomly and observe the changes of renal function, kidney pathology and vasoactive substances of the rats given the medicine in different periods. Results:Renal function injury, kidney tissue morphology, TXB2 as well as 6ketoPGF1a level and ET were markedly changed in rats receiving aristolochia manshuriensis Kom only. The protective effects were obvious in rats given aristolochia manshuriensis Kom in combination with ginkgo biloba leaf.Conclusion:Both the cytotoxic effect and renal ischemia coexist in the renal damage caused by aristolochia manshuriensis Kom. TXA2, PGI2 and ET all are invoved in the whole process and play an important role; Ginkgo biloba leaf has protective effect on the renal injury caused by aristolochia manshuriensis Kom.
    • 论文
  • 论文
    Effects of Ginkgo Biloba Leave Preparation on Myocardial Ischemia and Hemorheology in Patients with Senile Coronary Artery Disease
    DU Yongyuan;JIA Lianwang
    2003, 22(11): 763-766.
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    Objective:To observe effects of ginkgo biloba leave preparation (GBLP) on myocardial ischemia and hemorheololgy in patients with senile coronary artery disease (SCAD).Methods:Seventyeight cases of SCAD were diveded randomly into the treatment group (40 cases) and the control group (38 cases). The control group were treated with conventional method of sorbitrate and aspirin, and the treatment group were treated with GBLP 120mg P.O. tid ,on the basis of the conventional method. Both groups of patients were treated for consecutive 2 months. The parameters of blood lipids and hemorheology were measured and myocardial ischemia was assessed by dynamic electrocardiograms (Holter) before and after the treatment. Results:In the treatment group, the average levels of TC, TG, LDLC were lowered significantly(P＜0.01) and HDLC was increased (P＜0.05) while in control group, the leves of TC, TG, HDLC and LDLC were not different (all P＞0.05) before and after the treatment. Observation on hemorheology showed that whole blood viscosity under low or high shear rate, plasma viscosity, erythrocyte aggregation index, erythrocyte electrophoresis time and specific vilume, and fibrinogen in the GBLP after the treatment were markedly reduced (P＜0.01 or P＜0.05), the action of ameliorating hemorheologic parameters was superior to that in the control group (P＜0.05). Frequency and sustained time of symptomatic and asymptomatic myocardical ischemia were both decreased significantly in the two groups (P＜0.01 and P＜0.05 respectively) after the treatment, but the dectease was more marked in the treatment group than in the control group. No severe adverse effect was found in the followingup treatment with GBLP.Conclusion:GBLP exerts significant effects on lowering the blood lipids and improrving the conditions of hemorheololgy so as to be helpful in reducing the occurrence of myocardial ischemia. It is an effective and safe drug for the treatment of SCAD.
  • 论文
    Application Effect of Fufuchun Capsule on Withdrawal of Intrauterine Sterilizing Device at Later Stage of Menopause
    ZHANG Yafang;WU Suhua;HAO Guilian
    2003, 22(11): 766-767.
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    Objective:To study the application results of fufuchun capsule in intrauterine sterilizing device withdrawal operation at the later stage of menopause.Methods:80 cases of later stage menopause women were divided into 2 groups, 40 cases in the treatment group took fufuchun capsules for ten days before the intrauterine sterilizing device withdrawal operation, the other 40 cases in the control group take no fufuchun capsule before operation. Results:The operation successful rates in the treatment and control groups were 100.0% and 75.0% respectively. The operation time, difficulties in operation between the 2 groups were different statistically (P＜0.01).The other differences between the 2 groups were bleeding, device integrity and selfsensation (P＜0.05).Conclusion:In extracting the intrauterine sterilizing device from later stage menopause women, the fufuchun capsules can improve the operation environment of vagina, cervix and uterus, and make the operation easy to perform.
  • 论文
    A Therapeutic Evaluation of Compound Comb. Carraghenates Suppository for Simple Anal Fissure
    XU Bo;ZHU Guanghui;ZHUANG Simin
    2003, 22(11): 767-769.
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    Objective:To evaluate the efficiency and safety of compound Comb. Carraghenates suppository for simple anal fissure.Methods:100 cases were randomly divided into two groups, among them, 50 were given compound Comb. Carraghenates suppository, and the remaining 50 received potassium permanganate as contral group.Results:After the treatment, Comb. Carraghenates group showed less bleeding, pain and itching than the contral group. No systemic adverse reactions were found in both groups. Conclusion:Compound Comb. Carraghenates suppository is better than the conventional method of using potassium permanganate in treating simple anal fissure and has no obvious side effects.
    • 药物与临床
  • 药物与临床
    Mycophenolate Mofetil in the Treatmeat of 15 Cases of MPOANCA Positive Lupus Nephritis
    XIAO Houqin;ZHANG Jiane;ZHANG Qinhong;LUO Changxia;TU Mingli;ZHU Shaoming;LI Tao
    2003, 22(11): 780-782.
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    Objective:To study the effect and side effects of mycophenolate mofetil (MMF) in treating patients with myloperxidase antineutrophil cytoplasmic antibody (MPOANCA) positive patients with LN all were treated with MMF in combination with cirticosteroid. The starting dose og MMF ranged from 1.5 g•d1 to 2.0 g•d1, and followup study lasted for (14.56±5.10) months.Method:Clinical efficacy was defined as remission, partial remission and no responds. The dose of MMF was gradurally reduced to maintenance dose of 0.5－0.75 g•d1 after the patients achieved remission or partial remission.Results:Rensl remission occurred in 10 of 15 patients, 3 patients achieved partial remission, 2 patients achieved remission in 3 months. No obvious side effects were observed during MMF treatment.Conclusion:MPOANCA positive LN is a special type in pathology. The rates of hematuria and injury of renal function were higher than those of the ordinary type. MMF is effective for active glomerular lesion of refractory severs LN and has a higher remission rate in earlier period but less side effects.
  • 药物与临床
    Application of Pinaverin Bromide in Colonoscopy
    LIU Shuhui;LIU Nanzhi;WANG Nanxia
    2003, 22(11): 782-783.
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    Objective:To investigate the application of Pinaverin bromide in colonoscopy. Methods:All patients for colonoscopy were divided into two groups. The treatment group were given pinaverin bromide 150 mg P.O. after taking intestinecleaning liquid but before colonoscopy, while the control group were given only the intestinecleaning liquid.Results:The negative incidence of enterospasm was significantly higher (84.6%) in the treatment group than in the control group (40.0%). And the negative incidence of abdominal pain was also significantly higher (79.5%) in the treatment group than in the control group (27.5%).Conclusion:It is suggested that the application of pinaverin bromide can alleviate enterospasm in colonoscopy.It’s a safe simple and effective method.
  • 药物与临床
    Pituitary down Regulation by Triptorelin in Assisted Reproductive Technology
    ZHU Guijin;GONG Xuepeng;LIU Qun;LI Zhou;LIU Yuqing
    2003, 22(11): 784-785.
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    Objective:To compare the effects of two pituitary down regulation protocols triptorelin was administered in assisted reproductive technology (ART) and to study the correlation between serum concentrations of LH and outcome of ART.Methods:402 patients received triptorelin 0.1 mg every other day and 156 patients received triptorelin 0.05 mg daily during the midluteal phase prior to ovarian stimulation for IVF until HCG injection was given. Serum concentration of LH, progesterone and estrodial were measured before HCG injection. Results:Clinical pregnancy rate was 44.5% in 0.1 mg group, much higher than that in 0.05 mg group (P＜0.05), in which pregnancy rate was 34.9%, but no significant difference was found in ongoing pregnancy rate between tow groups. The average serum concentration of LH was 2.2 U•L1. There was no correlation between serum concentration of LH and outcome of ART when serum concentration of LH is below 10.0 U•L1. Conclusion:Injection of triptorelin 0.1mg every other day is a effective and convenience protocol to suppress LH surge and no correlation was found between serum concentration of LH and outcome of ART when serum concentration of LH is below 10.0 U•L1.
  • 药物与临床
    Clinical Efficacy of the Combination Plot of Recombinant Interferon and Ribavirin in the Treatment of Chronic Hepatitis C
    MEI Siqing;DENG Bin
    2003, 22(11): 786-787.
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    Objective:To observe the efficacy of the combination plot of recombinant interferon and ribavirin in the treatment of chronic hepatitis C (CHC). Methods:84 cases of CHC were divided into group A, B and C. The cases of group A were first treated by qd 3 million unit INFα2b, after 4 weeks by qod 3 million unit INFα2b and, in the meantime, were injected by 10－20 mg•kg1 ribavirin. the cases of group B were only treated by INFα2b, the dose being the same as group A. The cases of group C were first treated by qd 5 million unit INFα2b. The use of ribavirin being the same as group A. The HCVRNA and ALT of patients serum were detected by fluorescence quantity PCR and automatic biochemistry analyze. Results:After the 84 chronic hepatitis C patients had been treated for 40 weeks, the ALT persistent response rates of group A and group B were 70.6% and 47.1%. the HCVRNA persistent response rate were 50.0% and 26.5%. There was significant difference between the two groups(P＜0.01). The ALT and HCVRNA persistent response rate of group C is 62.5% and 43.7%, There is significant difference between the cases of group C and the cases (HCVRNA≥106 copies/mL) of group A(P＜0.05). Conclusion:The efficacy of the combination plot of recombinant interferon and ribavirin in the treatment of CHC is better than the INF alone. The INF dose for the cases of the high HCVRNA copies should be higher than that for the usual cases
  • 药物与临床
    Clinical Observation on Curing Neonatal Respiratory Distress Syndrome with Pulmonary Sunfactant
    LAN Li;XIA Chuanxiong;LIU Yaling;XU Chongmin
    2003, 22(11): 788-790.
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    Objective:To study the efficacy and clinical value of pulmonary surfactant (curosurf) replacement therapy in newborn infants with respiratory distress syndrome (NRDS). Method:In the 15 cases of NRDS cured with pulmonary sunfactant, we observed the changes of clinical manifestations, the results of blood gas, fraction of inspiratory oxygen (FiO2 )and Xray presentations of lungs after treatment. Results:The symptoms and signs of patients were improved quickly. The results of blood gas analysis were also improved, FiO2 decreased remarkably, the Xray pathological changes in the breast of patients were improved evidently. Conclusion:Pulmonary sunfactant has definite effect on neonatal respiratory distress syndrome and plays an important role in improving oxygen exchange and pathological changes in the lungs.
    • 药品质量控制
  • 药品质量控制
    Content Determination of Benzoic Acid and Salicylic Acid in the Iodobenzoic Acid Paint
    YU Jia;YANG Minfeng;SHANG Guomei;MA Ke
    2003, 22(11): 800-801.
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    Objective:To determine the content of benzoic acid and salicylic acid in the iodobenzoic acid paint. Method:Artificial neural network based on error back propagation was used.Results:The average recoveries and relative standard deviations of benzoic acid and salicylic acid were 100.24%, 0.23%, 99.62%, 0.42%, respectively. The results of three batches of samples agreed satisfactorily. Conclusion:The method was simple, rapid and accurate.
  • 药品质量控制
    Determination Method of Diclofenac Potassium by RPHPLC
    PENG Yan;SHI Zhen;ZHANG Hong
    2003, 22(11): 802-803.
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    Objective:To establish an RPHPLC method for the determination of diclofenac potassium.Method:Altima C18 (250 mm×4.6 mm, 5 μm) as the chromagraphic column and methelwateracetic(80:20:0.2)as the mobile phase were adopted.Results:The standard curves for diclofenac potassium were linear in the range of 10－200 μg•mL1, Y＝2.19×103＋0.0158X, r＝0.999 9.Conclusion:The method is sensitive and accurate. It can be used as the determination method of the quality standard of diclofenac potassium.
  • 药品质量控制
    Study on Release Rate of Lovastatin Sustainedreleasing Table
    YI Tao;YI Yimu
    2003, 22(11): 804-805.
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    Objective:To study the release rate and in vitro releasing characteristics of lovastatin sustainedreleasing table.Method:The sustainedreleasing effect was evaluated by in vitro release test. Results:It kept releasing for 24 h in sodium lauryl sulfate solution at pH＝7.0. The releasing rate conformed with zero degree dynamic equation and Higuchi equation. The accumulating releasing rate was above 95%.Conclusion:The method is simple,accurate and of good repeatition.It　shows a good sustainedreleasing character.
    • 药物制剂
  • 药物制剂
    Preparation and Content Determination of Compound Tinidazol Gargle
    LOU Yuefen
    2003, 22(11): 809-810.
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    Objective:To prepare compound tinidazole gargle, to establish method of content determination and to investigate drug stability. Method:Maximal wavelength and dualwavelength point spectrophotometries were used to determine the contonts of tinidazole and chlorhexidine acetate respectively. The stability was studied by accelerated test process. Results:Regression equation of tinidazole was C＝－0.039 68＋27.491A, r＝0.999 9. Regression equation of chlorhexidine acetate was C＝0.062 47＋50.454 8△A, r＝0.999 99. The precision and recovery rate were are favorable. There was no distinct fall in content under three different temperatures.Conclusion:The preparation is easy to preare and to determine,and with good stability.
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