中国科技论文统计源期刊　中文核心期刊  
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WHO《西太平洋地区医学索引》来源期刊  
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第七届湖北十大名刊提名奖  

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    特约稿
  • 特约稿
    Determination of Extract Ginkgo Biloba in Blood Plasma of Rabbits
    YANG Qijiang;WU Guozhong;XUE Wenjun;TANG Yuenian;WU Xiangqian
    2002, 21(11): 687-689.
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    Objective:To establish the method of determining extract ginkgo biloba(EGB) in blood plasma of rabbits by RPHPLC and study the pharmacokinetics of EGB in rabbits. Method:Hypersil column (100 mm×2.1 mm, 5 μm) of the analytical column was ODS. The mobile phase consisted of methanolwaterphosphate (32∶67.6∶0.4). The flow rate was 1.0 mL•min1. The UV detection was at 368 nm. Results:The lower limit of determination was 1.25 μg•mL1. The average recovery of the method was 98.82%107.80%. The related standard deviation (RSD) was ＜4%(n＝3). The linear limits of high and low blood concentrations ranged from 2.55.00 μg•mL1(r＝0.997 2, n＝5)and 6.2515.00 μg•mL1(r＝0.995 7, n＝5) respectively. Conclusion:The method of determination for EGB in the blood plasma of rabbits by RPHPLC is established in this experiment. It has the advantages of being easy to operate, accurate and sensitive.
  • 特约稿
    Effects of Melatonin on Focal Cerebral Ischemia in Rats
    MING Zhangyin;WANG Lihua;CHEN Jinhe;WU Jiliang
    2002, 21(11): 689-691.
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    Objective:To explore the protective effects and mechanism of melatonin on permanent focal cerebral ischemia.Methods:Brain ischemia was studied with 20 models of right middle cerebral artey occlusion (MCAO) for 30 min or 6 h or 24 h in rats. Brain damage was measured at the infarct area about the content of MDA and NO, and the activity of NOS. Moreover, alteration of ultrastructure was observed by transmission electronic microscope. Results:30 min after the onset of cerebral ischemia, the activity of NOS and the content of MDA and NO were increased; and 6 h after cerebral ischemia, the content of MDA progressively became stable, but the activity of NOS and the content of NO were decreased; 24 h after that, the activity of NOS and the content of NO were increased again. In comparison with the model group, Melatonin significantly diminished the infarct area and decreased the content of MDA during the course. It increased the activity of NOS and the content of NO in 30 min after cerebral ischemia and decreased them in 6 h and 24 h after cerebral ischemia. It also improved the pathologic change of the ultrastructure. Conclusion:Melatonin has a certain therapeutic effect on focal cerebral ischemia in rats, the mechanism of which may be associated with the decrease of the content of NO, the activity of NOS and neuronal apoptosis.
    • 药物研究
  • 药物研究
    Study of Protective Effect of Jindangantai in Active Liver Injury Model of Rats
    YANG Xixiong;YANG Chengxiong;LI Xiuying;CHEN Jun;WANG Tao;PANG Xuebing
    2002, 21(11): 692-693.
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    Objective:To testify the protective effect of jindangantai on liver injury. Methods:40 rats were randomly divided into a normal group(10 rats) and acute liver injury models(30 rats) indued by Ggalactosamine(DGalN). The models were divided into liver injury group, yiganning group, and jingdangantai group(10 rats each). The normal group and liver injury group were given no treatment, while yiganning group were given yiganning pills 6.0 g•kg1•d1 and jingdangantai group were given jingdangantai 10.0 g•kg1•d1, both by perfusation for 7 days. Serum alanine transaminase(ALT) and aspartic transaminase(AST) were detected. Changes of histopathology were observed by light microscopy. Results:The levels of ALT and AST were markedly decreased in Jingdangantai group compared with DGalN group (P＜0.05).The pathological injury was alleviated obviously. Conclusion:jingdangantai has a significant protective effect on liver cells
    • 五官科药物专栏
  • 五官科药物专栏
    Clinical Effect of the Combined Effect of Cetirizine and Biling in Treating Allergic Rhinitis
    YUAN Xiaoyang;FAN Xin
    2002, 21(11): 697-698.
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    Objective:To observe the combined effect of cetirizine and biling in treating allergic rhinitis. Methods:Allergic rhinitis patients were divided into the therapy group(600 cases) being given cetirizine 10 mg, qd, po and the control group(200 cases) being given loratadine 10 mg, tid, po, both groups were also given biling, 2 drops each time, tid, lasting for 24 d as a course of treatment.Results:The difference of clinical effect between the two groups was insignificant and the side effect was slight. The price of cetirizine is lower than that of loratadine. Conclusion:Since cetirizine is low in price and high in efficacy, it should be the drug of first choise for grassroot hospitals in the countryside and lowincome patients to treat allergic rhinitis.
    • 药物与临床
  • 药物与临床
    Clinical Observations on Therapeutic Effect and Safty of Ozagrel in the Treatment of Ischemic Cerebral Disease
    CAO Fei;SUN Shenggang;TONG Etang;LUO Fang;WANG Jing
    2002, 21(11): 703-704.
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    Objective:To observe the effect of ozagrel in the treatment of ischemic cerebrovascular disease. Methods:44 cases of cerebral infarction who were confirmed by craniocerebral CT were treated with 80 mg ozagrel solved in 500 mL 5% glucose injection or 500 mL 0.9% sodium chloride solution given by intravenous drip bid. The course lasted 2 weeks. According to “standard marking of clinical nervous function defects in apoplexy patients”, the curative effect was evaluated and managed statistically. Results:Ozagrel had significant effect in treating ischemic cerebrovascalar disease: 10 cases(22.7%) of cerebral infarction were relieved greatly and 25 cases (56.8%) improved. The overall effectiveness ratio accounted for 79.5%. The adverse reaction was mild. Conclusion:These results suggest that ozagrel is an effective and safe drug in the treatment of ischemic cerebrovascular disease.
  • 药物与临床
    Effect of Tacrolimus on Whole Blood Neutrophils Chemiluminescence of Renal Transplant Patients
    LIU Shiting;YANG Ling
    2002, 21(11): 705-706.
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    Objective:To examine the possible inhibitory effect of tacrolimus on luminoldependent chemiluminescence (CL) of whole blood neutrophils in renal transplant patients. Methods:Luminoldependent CL was used to measure active oxygen species generation in respirtory burst of whole blood neutrophils stimulated by zymosan A. Microparticle enzyme immunoassay was used to monitor the blood concentration of tacrolimus. Results:CL values of tacrolimus group (n＝46) decreased in comparison with those of normal group (n＝10) (P＜0.05). The serum of renal transplant patients directly inhibited respiratory burst of rats in a concentrationdependent manner (P＜0.05). Conclusion:Tacrolimus inhibits the phagocytic activity of neutrophils in renal transplant patients.
  • 药物与临床
    Therapeutic Effect of Levofloxacin on Multidrug Resistant Pulmonary Tuberculosis
    CHEN Zhaohui;NI Zhengyi;XU Jun;CAO Feng
    2002, 21(11): 707-708.
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    Objective:To evaluate the therapeutic effect of levofloxacin (LVFX) on multidrug resistant pulmonary tuberculosis (MDRPTB). Methods:122 cases of MDRPTB were allocated at random to two groups. Chemotherapy regimen: the therapy group were treated with LVFX＋3HThEK(C)/6HThE; the control group were treated with 3HThEPK(C)/6HThEP. Results:When chemotherapy was over, the sputum negative conversion rates and focal absorption rates of the therapy group were 88.5% and 80.3%, while the rates of the control group were 63.9% and 59.0% (P＜0.05). The effective focal absorption rates, cavity vanishing rates and symptom improving rates were all higher than those of the control group. Conclusion:Levofloxacin is an effective drug in treating patients with MDRPTB among quinolones.
  • 药物与临床
    Treatment of Shoulderhand Syndrome after Cerebral Infarction by βAescin
    CHEN Yunping;MEI Yuanwu;CHENG Shiqing
    2002, 21(11): 709-710.
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    Objective:To observe the therapy effect of βaescin on shoulderhand syndrome after cerebral infarction.Methods:24 patients were treated with βAescin by injection, 25 mg of the drug being dissolved in 250 mL of 0.9% sodium chloride solution, iv drip, qd for a 10day course of treatment.Results:The total effectiveness rate was 83.3%, the symptoms of the patients were significantly improved in 33.3% and partly improved in 50.0% of the patients.Conclusion:βaescin is an effective drug for the treatment of shoulderhand syndrome after cerebral infarction.
  • 药物与临床
    A Study on the Efficacy of Dioctahedral Smetite Combined with Clostridium Butyricum in the Treatment of Neonatal Diarrhea
    LI Ximu;DING Fengling;YU Zifeng
    2002, 21(11): 711-712.
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    Objective:To investigate the efficacy of Dioctahedral smetite combined with clostridium butyricum in the treatment of neonatal diarrhea. Methods:58 cases of newborn infants with diarrhea were randomly divided into treatment group (30 cases )and control group (28 cases). Dioctahedral smetite combined with clostridium butyricum were given to the patients in the treatment group, while only dioctahedral smetite in the control group. The same dosage was used in both groups: 1/3 pack each time, tid.Results:In the treatment group the obvious effectiveness rate and total effectiveness rate were 80.0% and 100%, while in the control group 57.1% and 78.5%. There was statistically significant difference between the two groups (P＜0.05). Conclusion:The effect of dioctahedral smetite combined with clostridium butyricum treating neonatal diarrhea is better than that of dioctahedral smetite alone.
  • 药物与临床
    Clinical Observation of Nimodipine in the Treatment of 30 Cases of Acute Cerebral Hemorrhage
    TAN Huan;CAO Fei;CHENG Shiqing
    2002, 21(11): 712-713.
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    Objective:To evaluate the effect and safty of nimodipine(capsules) to treat cerebral hemorrahge. Methods:30 patients were divided into two groups: control and treated. Patients of the treating group were treated with nimodipine 30 mg, 3 times a day, per os. It lasted 21 days for a course of treatment. Patients of the control group were treated with drugs other than nimodipine. Results: The effect of the treating group was better than that of the control group.Conclusion:It is suggested that nimodipine is a drug of choice for treating acute cerebral hemorrhage.
  • 药物与临床
    Effective Comparison of Lomefloxacin and Ciprofloxacin in Treating Acute Bacterial Infection
    LAI Lianqiang;WEN Yuguan
    2002, 21(11): 714-715.
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    Objective:To evaluate the efficacy and safety of lomefloxacin injection and ciprofloxacin in the treatment of acute bacterial infections. Methods:A total of 144 patients were divided into 2 groups. 72 patients of the therapy group received lomefloxacin injection 0.2－0.4 g, iv grip, qd, for 7－10 d. 72 patients of the control group received ciprofloxacin injection 0.2－0.4 g, iv grip, bid, for 7－10 d.Results:The effective rate and the bacterial clearing rate of the therapy group were 88.9% and 86.1% respectively, and those of the control group were 84.7% and 80.6% respectively. The adverse reaction of the therapy group was 5.6%, and that of the control group was 6.9%.Conclusion: Lomefloxacin is an effective and safe antibacterial drug in the treatment of bacterial infections. The usage of lomefloxacin injection is convenienter than ciprofloxacin’s.
  • 药物与临床
    Application of Calcium Hydroxide in Root Canal Therapy
    LU Yi;ZENG Kun
    2002, 21(11): 716-717.
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    Objective:To discuss the function of calcium hydroxide in treating irreversible pulpitis pulp necrosis and apical periodontitis and to observe its clinical effect.Methods:Root canals of 110 patients were disinfected by using calcium hydroxide paste. The number of patients completing root canal hermetization in once was 86.4 percent (95 patients). The number of patients of pulp diseases and periapical diseases, who completed root canal hermetization with calcium hydroxide paste was 80. Results:After continuous observation of more than 2 years, the validity of treatment was 96.3 percent. Conclusion:Using calcium hydroxide in disinfecting marrow cavity and root canal and using calcium hydroxide paste for root canal filling is an effective method in root canal therapy.
    • 药品质量控制
  • 药品质量控制
    Assay of Dltetrahydropalmatine in Compound Rhizoma Corydalis Tablets by TLCS
    SONG Jinchun;YANG Ji;LUO Shunde
    2002, 21(11): 733-734.
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    Objective:To develop a method for the determination of dltetrahydropalmatine in compound rhizoma corydalis tablets. Method:Dltetrahydropalmatine was assayed by dualwavelength TLCScanning method with 340 nm and 365 nm as the sample and reference wavelength respectively. The mobile phase was benzenepetroleum ether (90～120℃) methanolchloroform (3∶3∶0.5∶10). Results: The average recovery was 98.2% (RSD＝1.88%, n＝5) with good linear relationship (r=0.999 6). The linear range was from 0.2 to 1.4 μg.Conclusion:The method was simple and accurate and can be used for the quality control of compound rhizoma corydalis tablets.
  • 药品质量控制
    Content Determination of Paeoniflorin of Shiquandabu Pill with ReversedPhase HPLC
    JIA Shanxue;DOU Zhonghua;CHEN Zhizhong;ZHAOWei
    2002, 21(11): 735-736.
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    Objective:To dominate the quality of shiquandabu pill, the content of paeoniflorin in shiquandabu pill was Determined by ReversedPhase HPLC(highperformance liquid chromatography). Method:Paeoniflorin was separated on spherisorb C18 column by using acetonitrile0.1% phosphoric acid (15∶85) as mobile phase and wavelength detection at 230 nm by UV.Results:The resolution was 3.9; The number of theoretical plates calculaled for paeoniflorin peak was 35 440; The average recovery of the added index was 99.0 %(n＝5). RSD obtained by 5 times of determination was 0.90%. There was a good linear relationship between the concentration of paeoniflorin and absorption area value in the range of 0.252.50 μg.Conclusion:The method is highly reproducible and accurate.
  • 药品质量控制
    Improve on the Methods for Determining the Content of Paracetamol in Wei C Yingqiao Tablets
    SONG Hui;CHEN Weifei
    2002, 21(11): 737-738.
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    Objective:To establish a method for determining paracetamol in wei C yingqiao tablets.Method:Highperformance liquid chromatography(HPLC) and dualwavelength spectrophotometry were used to determine the content of paracetamol in different batches of wei C yingqiao tablets. Results:The method of dualwavelength spectrophotometry is complicated and inaccurate, while the method of HPLC is simple, rapid and accurate.Conclusion:The method of HPLC is accurate and credible. It can be used for quantitative analysis of wei C yingqiao tablets.
    • 用药指南
  • 用药指南
    Costeffectiveness Analysis of Three Kinds of Pancreatin Inhibitors in the Treatment of Acute Pancreatitis
    MA Ke;WANG Guifa
    2002, 21(11): 743-744.
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    Objective:To evaluate the costeffectiveness of three kinds of pancreatin inhibitors in the treatment of acute pancreatitis.Methods:67 patients with AP were divided into three groups according to the therapy drug:ulinastatin group(20 patients), sandostatin group(22 patients), and stilanin group(25 patients). The costeffectiveness of the three kinds of pancreatin inhibitors were evaluated by the pharmacoeconomics method.Results:There is no significant difference in clinical efficacy indexes among the three groups. But the cost of the stilanin group is much higher than the other groups, and the cost of ulinastatin group is the lowest. Conclusion:Ulinastatin is the drug of first choice in the treatment of acute pancreatitis.
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