特约稿
CHANG Shuying;CHEN Shiming;CAO Qilong;LIU Ping;WANG Fugui;WANG Zhongxiao
2002, 21(05): 263-265.
Objective:To survey the effect of huperzine A (Hup A) to promote verbal recall in middleaged and elderly patients with dysmnesia of varying severities. Methods:50 middleaged and elderly patients with dysmnesia were given each placebo or Hup A 100μg, po, bid. for 2 weeks, according to the randomized double blind crossing medication method. Multiple selective verbal reminding tests were conducted before and after the medication. As auxiliaries, topographic mapping of the brain and determination of blood cholinesterase activity were also performed. Results:In patients with mild and moderate dysmnesia, values of Σ recall(ΣR) were increased by 0.91±3.60 and 0.86±1.79, respectively, in those given placebo, and 6.05±2.87 and 6.43±2.24, respectively, in those given Hup A. Longterm retrievel(LTR), Longterm storage(LTS), Consistent LTR(CLTR) and Unreminded recall(UrR) were also increased similarly. While the values of shortterm recall(STR) were increased by 0.90±3.32 and 0.71±2.95, respectively, in those given placebo; they were; however; decreased by 1.90±3.78 and 2.36±2.62, respectively, in those given Hup A. Similar changes were also noticed in the values of random LTR(RLTR), presentation(Pr), reminded recall(RR) and pass number(PN). There were 24 cases given placebo and only 10 cases given Hup A who could not pass the complete verbal recall tests for 11 times. Improved or normalized topographic mapping of the brain was found in 13 patients given Hup A. All these differences are statistically significant or highly significant. In contrast, Hup A was found to have no evident effect on most patients with severe dysmnesia. No severe adverse reactions and inhibition of blood cholinesterse activity were encountered during the treatment with Hup A. Conclusion:Hup A has a fair effect to improve the ability of verbal recall, retention and repetition in patients with mild and moderate dysmnesia.
