Herald of Medicine

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特约稿

Essential Principles of Antimicrobial Therapy

Gao Meiying

2000, 19(2): 99-102.

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Antimicrobial agents are specific in the treatment of the infectious disease. Their effects are dependent on the accuracy of diagnosis for infectious disease and proper choice of the antimicrobial agents for the causative microorganism. The essential principles of antimicrobial agents application, used for treatment, used for prophylaxis, and combined antimicrobial therapy are reviewed. The empirical treatment with the broadspectrum antimicrobials is appropriate in many of severe infectious diseases before the laboratorial report obtained.

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药物研究

Effect of Stevioside on Hemodynamics in Anesthetized Rats

Xia Jinmin;Li Fang;Xu Deyi;Ding Yishang

2000, 19(2): 103-104.

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Objective:Effects of stevioside on hemodynamics of anesthetized rats were observed.Methods:Wistar Kyoto (WKY) rats and sponteneous hypertensive rats received operation after using pentobarbital anesthesia. Drug trial with stevioside was condacted 10 min after operation.Results:The normotensive WKY rats’ systolic pressure and distolic pressure were declined in presenting dose dependent after given intraveneously 25, 50, and 100 mg/kg, respectively, especially the distolic pressure; while the heart rate, the maximal ascending rate of left ventricular pressure, and maximal changing rate of left ventricular logarithm value were decreased.Conclusion:Stevioside has a higher and persistant hypotensive effect, while heart rate and myocardial contraction can be inhibited.

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药物研究

Preparation of Rufloxacin Hydrochloride Cream

Wang Xiaosheng;Ma Li

2000, 19(2): 106-107.

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To prepare rufloxacin hydrochloride cream.Methods:The composition of
recipe and manufacturing technique were designed. The content of rufloxacin hydrochloride
was determined by UV spectrophotometry and stability tests were carried out.Results:The
designation of the recipe as reasonable and manufacturing technique was feasible, the
recovery of rufloxacin hydrochloride was 99.57%. The stability tests of preparation showed
not remarked change.Conclusion:The preparation is rational in formula and reliable in
method of quality control.

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药物研究

Experimental Study on Regulation Action of Wendan Jiangzhi Oral Fluid for Serum Fat of Adult Rat

Gao Jiandong;Xue Qinglin;Gao Zhen;Fu Rongshu

2000, 19(2): 108-109.

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To prove the regulating action of Wendan Jiangzhi Oral Fluid for serum
fat of adult rat.Methods:The influence of Wendan Jiangzhi Oral Fluid on TG, TC, fat content
in abdominal cavity, body weight of adult rat were observed. Compared with Chinese
traditional medicine (Jiao GU Lan) or Western medicine (Lopid )were conducted.Results:TG
and TC of three group had reduced in different degree after 21days. The impact of
experimental group was better than others groups (P＜0.05). The fat content in abdominal
cavity and body weight in these groups showed different notably.Conclusion:Wendan Jiangzhi
Oral Fluid can reduce notably TG, TC, fat content in abdominal cavity and body weight of
adult rat.

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药物研究

Protective Effect of Angelica Sinensis on Experimental Hepatic Fibrosis in Rats

Li Qing;Deng Changsheng;Zhu Youqing

2000, 19(2): 110-110.

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Objective:To study the protective effect of angelica sinensis on experimental hepatic fibrosis.Methods:The rats which the hepatic fibrosis was induced by 40% CCl4, SD, were divided into normal controlled (n＝10), model(n＝10) and angelica sinensis groups (n＝10), liver histopathology was observed under light microscope. The levels of serum ALT, AST and serum procollagen type Ⅲ (PC Ⅲ) were determined.Results:The levels of serum ALT、AST and PC Ⅲ in angelica sinensis group were significantly lower than those in the model group and the liver fibrosis of model group was severer than that of angelica sinensis group.Conclusion:Angelica sinensis can inhibit the experimental liver fibrosis.

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其他

Progress of Antiviral Drugs for Viral Diseases

Deng Bing;Yuan Guanghui

2000, 19(2): 112-113.

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There were high incidences and wide prevalences in viral diseases. The pharmacotherapy progress of antiviral drugs, including human immunodeficiency virus, respiratory virus, herpes virus, human papillona virus, and hemorrhagic virus, were expound.

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其他

Significance of Opioid Peptide Antagonist-Naloxone in Treatment of Epidemic Encephalitis B

Yao Wenhu;Lin Houji;Zhao Hong

2000, 19(2): 115-116.

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Objective:In order to study the relationship between the pathogenesis of epidemic encephalitis B and endogenous opioid peptide as well as the clinical mechanism and the curative effect with the opioid peptide antagonist-naloxone to treat encephalitis B.Methods:106 patients were enrolled and randomly divided into naloxone group and control group. 56 patients were treated with naloxone and 50 patients didn’t receive naloxone treatment. But the two group received the same therapy in other aspects. Their curative effects were observed, menawhile in acute period and convalescent stage, the contents of endogenous opioid peptide in plasma and cerebrospinal fluid (CSF) in all patients were measured by biochemical analysis.Results:The clinical curative effect of naloxone group was higher than the control group. The contents of endogenous opioid peptide in plasma and CSF in acute period were higher than normal (P＜0.01) and obviously declined when entering into the convalescent stage (P＜0.01), and the decline of naloxone group was more markable than that of the control group.Conclusion:There is significance correlation between the pathogenesis of encephalitis B and the increase in contents of endogenous opioid peptide. Naloxone is one of the effective medicines to treat encephalitis B since it can obviously decreases the contents of endogenous opioid peptide.

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其他

Development of the Research on the Schistosomiasis Vaccines

Song Hailin;Jie Shenghua;Chen Yingwen

2000, 19(2): 117-118.

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Objective:To introduce schistosomiasis vaccine alternative antigen and schistosomiasis vaccine.Methods:To review the investigating history that involving potential schistosomiasis vaccine alternative antigen and antigen molecule, artificial carrier vaccine, the structure of the genetic engineering strain, the triburation of the polvalent vaccine, antiidiotypic antibody vaccine, schistosomiasis synthetic polypeptide vaccine and antiovimmunity.Results:Research on Schistosomiasis vaccine has pushed forward.Conclusion:Protective immunity of schistosomiasis vaccine on schistosomiasis infection is probable.

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其他

Investigation of Minimal Inhibitory Concentration of 77 Cases of Chloramphenicolresistant Salmonella Typhi

Yu Can

2000, 19(2): 125-126.

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Objective:In order to investigate the relation between the chloramphenicolresistant salmonella typhi and the common drugs for
typhoid.Methods:Salmonella typhi strains cultivated which were collected from blood or stool. The MICs were tested with chloramphenicol, SMZ,
kanamycin, tetracycline and ampicilin.Results:Of 101 salmonella typhi, 77strains are insensitive to chloramphenicol or more than two of the above
drug; of 77 strains, 72 were resistant to three or more than three drugs.Conclusion:The strains of chloramphenicolresistant Salmonella typhi were
more resistant to the common drugs for typhoid, but more sensitive to aminoglycoiside antibiotics.

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其他

Treatment of 2 Cases of Severe Cerebral Schistosomiasis by High Dose of Praziquantel

Zhang Yuqi;Zhang Juan

2000, 19(2): 127-128.

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Objective:To observe the therapeutic effects of high dose of praziquantel to treat severe cerebral schistosomiasis.Methods:Praziquantel in
a dose of 140 mg/kg (total dose 7 000 to 8 400 mg, 0.4 g/time, tid, po) was used. In the therapy duration of a period of 7 days, despite a
remission of symptoms and signs, but the good therapeutic effects were not obtained, then, another one to three duration treatment of praziquantel
was given.Results:Both cases’ symptoms and signs were controlled and both patients were cured.Conclusion:Under the observation with caution, high
dose of praziquantel with multiple duration to treat severe cerebral schistosomiasis can obtain a good therapeutic effects, being safe and
reliabel.

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其他

尚平易洋余斌斌袁润强

2000, 19(2): 129-129.

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其他

Recent State in Treatment of Bacillary Dysentery Tolerant of Drugs

Zou Gang

2000, 19(2): 136-136.

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Objective:To study the recent state in the treatment of bacillary dysentery tolerant of drugs.Methods:The literature about the action
mechanism and clinical efficacy of usual several antibiotics for the tolerant of drugs bacillary dysentery were reviewed and evaluated.Results:The
results showed that sodii cefotaxime, sodii cefoperazone, ofloxacin, ciprofloxacin,amikacin sulfate, levofloxacine lactate, and polymyxin E
sulfate had good efficacy in improvement of clinical manifestation and bacillary resumed normal, and also. The bacteria tolerance of sodii
cefotaxine, ciprofloxacin and amikacin had occured.Conclusion:The therapy of multidrugtolerance bacillar dysentery should be on the basis of
bacterial sensitivity to select high effective antibiotics, which my be combined, and the enough therapy duration in need.

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药物与临床

353 Patients with Dermatitis Treated with Risuan Lotion

Xiao Yongze;Zeng Zhiliang;Sun Zengzheng

2000, 19(2): 138-139.

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Objective:In order to investigate the curative effect of Risuan lotion to 353 patients with dermatitis and eczema and inhibiting effect to infectious microbe.Methods:Risuan lotion was diluted with boiled water in the ratio of one to ten. The lesions were treated by wash or hip bath with Risuan lotion for five to ten minutes, two times daily. There was seven to ten days for one therapy duration.Results:Effective rate was 83.3%. Bacterial suppresion tests to candida albicans, trichophyton rubrum, Staphylococcus aureus, and Neisseria gonorrhoeae were conducted in vitro. It was showed that Risuan lotion had the action of bacterial suppression in different degree. There is no systemic hypersensitivity and stimulation to local skin.Conclusion:In same production, the price of Risuan lotion is cheap. It is worth to be used extended.

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药物与临床

郑玲马玉美

2000, 19(2): 139-139.

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药物与临床

Risperidone for OpenTreatment in 31Female Schizophrenia

Liu Xiaoping;Li Xangyu;Wen Youseng

2000, 19(2): 140-141.

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Objective:To get some knowledge of the effetiveness and safety of risperidone for female schizophrenic treatment.Methods:31 subjects was entered with CCMDⅡR schizophrenic diagnosis standard. Age 18～60 years, course of disease＞3 months, BPRS≥27, the average dosage of risperidone was 3.26±1.18 mg/d, the duration of treatment was 16 weeks, BPRS, CGI were used to evaluate the medicine curative effect and TESS were use to evaluate the side effects.Results:Risperidone total effective rate was 96.77%, of which, significant response accounted for 74.19% (23/31), improvement accounted for 22.58% (7/31), invalidity accounted for 3.23%(1/31). The major side effects of the medicine were insomnia, constipation, EPS, weight gain, and lactation.Conclusion:Risperidone was effective and high safe for female schizophrenia.

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药物与临床

A Controlled Trail for Comparing Clozapine Combined with Pipotiazine Palmitate to Clozapine Alone in the treatment of Negative Symptoms in Schizophrenic Patients

Jia Zhanling;Zhang Zeng;Jin Shili

2000, 19(2): 142-143.

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Objective:To compare clozapine combined with pipotiazine palmitate to clozapine alone in the treatment of negative symptoms of schizophrenic patients.Methods:50 inpatients with diagnosis of chronic schizophrenia and with negative symptoms were treated with clozapine combined with pipotiazine palmitate or clozapine alone. Clinical progress was monitored with BPRS, SNAS.Results:There were 58.0% of and 37.% of response rate in clozapine combined with pipotiazine palmitate group and in clozapine alone group, respectively. The decreases of SANS were 66.0% and 53.4% in two groups, respectively. There was a significant difference between two groups.Conclusion:Paitents with negative symptoms of schizoprenic can be improved effectively with clozapine combined with pipotiazine palmitate.

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药物与临床

Clinical Comparative Study on Paroxetine in Treatment of Depression

Ma Jun;Wei Haiyan;Niu Yi;et al

2000, 19(2): 144-145.

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Objective:To study the paroxetine’s curative effect in the treatment of depression.Methods:There was an open and comparative trial. 60 patients, who were diagnosed with the criteria of affect disorder of CCMD2R, were divided into paroxetine group and amitriptyline group. ALl patients were evaluated by HAMD、CGISI and Tess at week 1 and week 6 during the research, respectively.Results:The response rates were 70.0% and 76.7% in paroxetine group or amitriptyline group, respectively. There was no significant difference in the efficacy between paroxetine and amitriptyline (P＞0.05). Side affect in paroxetine is less than in amitriptyline group.Conclusion:Paroxetine is more effective than traditional antidepressant in the treatment of depression.

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药物与临床

Schizophrenia Showing Predominantly as Negative Symptoms Treated with Risperidone

Zhai Jinguo

2000, 19(2): 146-146.

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Objective:To observe the therapeutic effect and side effect of risperidone in the treatment of schizophrenia of which clinical predominant
feature were negative symptoms.Methods:Risperidone was given orally 2～8 mg/d for 10 weeks in 38 inpatients with schizophrenia showing
predominantly as negative symptoms. The therapeutic effects were evaluated with SANS and the criterion of clinical curative effects.Results:The
obvious response rate was 50.0%, and the effective rate was 78.9%. The common side effects were extrapyramidal symptoms.Conclusion:Risperidone is
preferred to be an ideal agent in the treatment of schizophrenia showing predominantly as negative symptoms.

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药物与临床

Comparision Between Fenodipine and Benazepril in Treatment of Hypertension

He Jing;Li Shuguang;Gao Min;et al

2000, 19(2): 148-149.

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Objective:To evaluate the effect and safety of fenodipine in treatment of slightmiddle degree of hypertension and to compare the
effective between fenodipine and benazepril.Methods:In 50 elder hypertensive patients, radomized and singleblind controlled study was done.
Fenodipine 5～10 mg/d orally, benazepril 5～10 mg/d orally, continued for 4 weeks.Results:In occasional determination, there is no difference in
hypotensive effects between fenodipine and benazepril. But both of 24hours and day mean hypotensive effects fenodipine is more effective than
benazepril.Conclusion:Fenodipine and benazepril are a lastacting effective hypotensive drugs.

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药物与临床

Application of Costeffectiveness Analysis of Therapeutic Scheme of Peptic Ulcer

Zhao Jianzhong

2000, 19(2): 150-151.

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Objective:In order to evaluate the economic effectiveness in different pharmacotherapeutic schemes for the same disease.Methods:135
patients with peptic ulcer were selected from literature reports. These patients were radomly divided into four groups which received different
therapeutic schemes (A:dioctahedral smectite＋ranitidine; B:ranitidine; C:omprazole; D:colloidal bismuth subcitrate). Their economic effectiveness
were evaluated by pharmacoeconomic costeffectiveness analysis.Results:A was the best scheme.Conclusion:Pharmaconomics is very important in
selecting optimizing therapeutic scheme, guiding rational use of drug and increasing economic effectiveness.

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药物与临床

Idiopathic Thrombocytopenic Purpura Treated with High Dose Intravenous Gammaglobulin

Gu Xiaohua;Chen Dongzhen;Zhou Dianding;et al

2000, 19(2): 152-153.

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Objective:To evaluate the effecte of high dose of intravenous gammaglobulin (HDIVIG) used for idiopathic thrombocytopenic purpura (ITP) in
childhood.Methods:In HDIVIG treatment groups 12 children diagnosed as ITP received either IVIC 0.4g/(kg·d) for five days or IVIG 1.0 g/(kg·d)
for two days. In corticosteroid controlled groups, 12 cases received oral prednisone, intravenous mrthylpreduisolone or dexamethason,
respecitively.Results:The effective rate was 83.0% in children given IVIG. Whereas the effective rate was 66.0% in those given
corticosteroid.Conclusions:In this retrospective analysis, HDIVIG was more effective than corticosteroid in the treatment of ITP in children. In
treatment groups, HDIVIG for five days was more effective than for two days, and the duration of platelet count peak was long.

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药物与临床

Recovery of Enterokinesia Promoted with Cispride After Laparoscopic Cholecystectomy

Ye Guanxiong;Wang Xinmei;Xu Yonghong;et al

2000, 19(2): 159-159.

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Objective:To observe the efficacy of recovery of enterokinesia promoted with cisapride after laparaoscopic cholecystectomy(LC).Methods:100
patients were radomly divided into 2 groups in a prospective study groups.Results:In treatment group, the enterokinesia recovery time ranged from
8 to 37 hours (mean 16.81), but it ranged from 20 to 72 hours (mean 40.13) in the control group. There was a statistically significant between two
groups (P＜0.01)。Conclusion:The enterokinesia recovery can be promoted with cisapride after LC.

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其他

Advances of Research on Pharmacotherapy of Congestive Heart Failure

Ruan Zhipeng

2000, 19(2): 179-180.

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Objective:To expound the advancement of pharmacotherapy of congestive heart failure.Methods:To review the drugs such as digitalis,
vasodilators, calcium antagonists, angiotensin converting enzyme inhibitors, betablockers.Results:to pose new direction for congestive heart
failure.Conclusion:It is suggested that drugs influencing renin angiotensin system may be of value in treatment of congestive heart fialure.

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用药指南

Dynamic Analysis of Utilization of Antibacterial Drugs in First People’s Hospital of Xiantao in 5 Years

Tang Chao;Li Danping;Liu Aiping

2000, 19(2): 185-186.

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Objective:To analyze the dynamic usage state of antibacterial drugs in first people’s hospital of Xiantao, and promot the proper
utilization of antibacterial drugs in the country.Methods:Compare the consumption of antibacterial drugs of the hospital in 5 years with the unit
of DDDs·d-1 and calculate the average increasing rate of DDDs·d-1 of every drugs.Results:Different from the usage of inside and outside the
country.Conclusion:Physicians should pay attention to proper clinical usage of antibacterial drugs.

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