中国科技论文统计源期刊 中文核心期刊
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
With the rapid development of modern medicine and pharmacy, the diagnosis and treatment of cancer have made great progress. However, cancer treatment is still a difficult and urgent problem in clinic, because the early detection is difficult for many tumors, the toxic and side effects are serious for drug therapy and treatment effect is poor. Long circulating liposomes delivery system based on nano-medicine are used for the diagnosis and treatment of tumors, which have brought new hope to cancer patients. After administration, long circulating liposomes are known for prolonging the circulation time, increasing the targeting accumulation in tumor, improving the effects of diagnosis and treatment and reducing the toxic and side effects of loading medicine or probe. In this paper, the advantages of long circulating liposome delivery system loaded with diagnostic probe or antitumor agent in targeting diagnosis and treatment of tumor are reviewed.
The course of pharmaceutical analysis for pharmacy undergraduate students in National University of Singapore and China Pharmaceutical University was compared, in terms of curriculum, lecturing, assessment and practical teaching. This study provides in-depth analysis by the lecturers from both universities,and can provide reference for teaching reform and course construction of pharmaceutical analysis.
Objective To investigate the effect and the potential mechanisms of low molecular polysaccharide from agaricus blazei (LMPAB) on H2O2-induced oxidative injury in hippocampal neuronal cells of rats. Methods Hippocampal neuronal cells were isolated from SD rats (24 h) and grew in culture. Cultured cells were divided into normal control group (added the same amount of nutrient solution), model control group (added 500 μmol·L-1H2O2 solution) and LMPAB high, medium, low dose groups (added 20,10,5 mg·L-1 LMPAB solution, respectively, then added 500 μmol·L-1 H2O2 solution each). The hippocampal neuron cell activity was detected with MTT method. The hippocampus neuron mitochondrial membrane potential (MMP) was detected by flow cytometry. According to the reagent instruction methods, malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities were detected. Results The activities of cell, CAT, SOD, GSH-PX and MMP in normal control group and the LMPAB high dose group were significantly higher than those of model control group (P<0.01); The content of MDA in normal control group and LMPAB high dose group was significantly lower than that of model control group (P<0.01). Conclusion The protective effect of LMPAB on hippocampal neurons with H2O2-induced injury may be related with the mechanism of enhancing the neuronal antioxidative capacity.KEY WORDS Polysaccharide from agaricus blazei, low molecular; Neurons,hippocampal; Oxygen free radical; Antioxidant enzymes
Objective Determination of polysaccharide content in dried peel seeding watermelon, and its mechanism of lowering blood glucose. Methods The content of polysaccharides in dried peel of seeding watermelon was determined by the method of phenol-sulfuric acid. Mice were given starch and sucrose load,and the mouse blood glucose was examined.The inhibitory activities of seeding watermelon against α-glucosidase were tested by the colorimetry of pNPG. Results The calibration of polysaccharide was A=0.066 4 C+0.022 6, R2=0.999 5, the content of polysaccharide in dried peel of seeding watermelon was 4.45% (n=10,RSD=1.80%); 50,100 and 150 mg·kg-1 of polysaccharide could significantly reduce the starch load in mice blood glucose(P<0.01);100 and 150 mg·kg-1 of polysaccharide significantly reduced sucrose load blood glucose(P<0.01); polysaccharide concentration in 18 mg·mL-1 could significantly inhibit the activity of α-glucosidase as the inhibitory rate was (73.19±3.45)% (n=10). Conclusion Seeding watermelon polysaccharide has effect on lowering blood glucose in starch and sucrose load mice, and inhibits α-glucosidase significantly.
Objective To explore the mechanism of immunoregulation by investigating the effects of polysaccharides from Millettia speciosa Champ (MSC) on proliferation of spleen lymphocyte and secretion of cytokine in mice. Methods The effects of MSC polysaccharides on Con A-induced spleen T lymphocyte proliferation were determined by MTT. The contents of TNF-α, IL-6 and PGE2 were determined by ELISA. Results The Con A-induced T lymphocyte proliferation was significantly increased by MSC polysaccharides at the concentrations from 50 to 200 μg·mL-1.Coupled with TNF-α and IL-6 were significantly increased while PGE2 was significantly decreased. Conclusion MSC polysaccharides could increase proliferation of spleen lymphocyte and enhance the immune responses by increasing the secretion of TNF-α and IL-6 in mice.
Objective To verify the antiviral effects of Siji Kangbingdu mixture (SJKBDM) against coxsackievirus A16 (CoxA16). Methods Vero cells and 5-day-old suckling mice, injected with 75/50 and 1×106 TCID50 CoxA16, were used as evaluation models. The preventive influences of SJKBDM against CoxA16 in Vero cells were assessed in the models. The effects of SJKBDM on the mortality, survival time, change rate of body weight, and clinical symptom scores of suckling mice were observed. Results ①The half maximal inhibitory concentration of SJKBDM on Vero cells was 9.59 mg·mL-1. ②Toxic effects were not observed from 32.3 g·kg-1 single dose or continuous intraperitoneal injectin of SJKBDM in suckling BALB/c mice. ③The SJKBDM had significant inhibitory effect against CoxA16 virus. Doses higher than 1.22 mg·mL-1 could significantly improve the Vero cell survival rate, and the SJKBDM inhibition of 75/50 TCID50 CoxA16 induced pathological changes in Vero cells. ④The SJKBDM significantly improved clinical symptoms of mice with CoxA16 viral infection, especially with crude drug doses of higher than 1.62 g·kg-1. The survival rate and other indicators were comparable or slightly higher compared with ribavirin, and the clinical score was higher than that of ribavirin. Conclusion The SJKBDM has significant inhibitory effect on CoxA16 cell proliferation, significantly decreases death rate, and improves clinical symptoms of mice infected with CoxA16 virus.
Objective To explore the anti-inflammation, pain-relieving and bleeding-stopping effects of Veronicastrum sibiricum and its potential to be a medicinal resource of Radix clematidis. Methods Total of 120 mice were randomly divided into 6 groups, including the Veronicastrum sibiricum water extract (1.5, 1.0, 0.5 g·mL-1) groups, Radix clematidis water extract (1.0 g·mL-1) group, the 0.9% sodium chloride solution group and 2% aspirin solution group. The mouse hot-plate test and writhing test were carried out to evaluate the analgesic effect. The anti-inflammation effect was observed by the xylene-attracted swelling of the mouse's ears.The bleeding time of the breaking mouse's tails was used for studying hemostatic effect. Results The Veronicastrum sibiricum could significantly increase the pain threshold of mice in hot plate. At the same dosage, the Veronicastrum sibiricum reducing the writhing times of mice was similar to Radix clematidis. Auricle swelling inhibition rate was 5.72% higher than Radix clematidis (P<0.05); The mouse tail bleeding time was 7.6% shorter than Radix clematidis (P<0.05). Conclusion The Veronicastrum sibiricum shows similar analgesic effect to Radix clematidis,and more strong hemostatic and anti-inflammation effects than Radix clematidis.
Objective To evaluate the toxicity of the intra-articular injection of bevacizumab in the knee of the rabbit. Methods Thirty-two rabbits were divided into 3 experimental groups and normal control group.Three experimental groups were received intra-articular injection of bevacizumab (1, 2, 4 mg respectively) once every three weeks for two times and the normal control group was received the same amount of 0.9% sodium chloride solution. The animals were sacrificed after 6 weeks. Blood test was examined before and after treatment. Pathologic examinations of liver, kidney and artiluar tissue were taken after the sacrifice. The hematoxylin and eosin stain for synovium and cartilage were performed. The AB-PAS stain and Mankin's scale for cartilage were performed. Results All the rabbits kept normal physiological activity. There was no significant difference of major organs and articular tissue between experimental groups and normal control group. There was no significant difference for WBC, RBC, PLT, ALT, BUN and Mankin's scale among all groups. Conclusion No systemic toxicity effects were found for the intra-articular injection of bevacizumab in the knee of the rabbit.
Objective To observe the recovery efficiency of sufentanil and oxycodone hydrochloride in neurosurgical operation. Methods Total of 120 patients scheduled for microvascular decompression under general anesthesia were randomly divided into 4 groups to receive 0.03 mg·kg-1 oxycodone (group H1), 0.05 mg·kg-1 oxycodone (group H2), 0.08 mg·kg-1 oxycodone (group H3), and 0.08 μg·kg-1 sufentanil (group S). Each patient accepted 4 ng·mL-1 of remifentanil and 5-6 mg·kg-1·h-1 of propofol after induction to maintain bispectral index (BIS) value at 40-60. On starting to suture dura mater, oxycodone or sufentanil was given in various doses through intravenous route. The BIS value, the amount consumption of propofol, anesthesia and operation duration, and the drug delivery time of each group were recorded.The time of spontaneous breath recovery, awaking and extubation, verbal rating score (VRS) and sedation score (SS) at 10 min, 20 min, 30 min after operation as well as side-effects were also recorded. Results The VRS scores had no statistic difference among the groups at 10 min after operation, while the average scores of H1 were higher than those of H2 and H3 at 20, 30 min after operation. No statistic difference of the SS scores was showed among 4 groups at 10 min after operation, but it was lower in group H1 than those in group H3, and lower in group S than those in H2 at 20 min after operation; group H3 had a significantly higher SS scores than H1, H2 and S at 30 min after operation. Conclusion Oycodone hydrochloride 0.05 mg·kg-1 or sufentanil 0.08 μg·kg-1 can both provide satisfactory recovery quality in neurosurgical operation.
Objective To observe the effect of subarachnoid block with 0.5% bupivacaine at different temperatures during cesarean section. Methods 100 cases of elective cesarean section were randomly divided into room temperature group and heating group,50 cases in each group. Room temperature group: bupivacaine hydrochloride injection and glucose injection equilibrated group in a constant temperature thermostatic bath of 24 degrees thermostatic bath heating for above 30 min. Heating group: bupivacaine hydrochloride injection and glucose injection heated in the constant temperature thermostatic bath of 37 degrees thermostatic bath heatingfor above 30 min. Anesthesia was injected into the subarachnoid space at different temperatures to observe the anesthetic effect. Results The anesthesia increased rapidly, and the analgesia and muscle relaxation effects were better in the heating group than room temperature group, but the heating group had hypotension rate was higher than the room temperature group (36.0% vs. 16.0%). There was no obvious difference between the incidence of adverse reactions such as nausea and vomiting in both groups. Conclusion Different temperatures of bupivacaine can be used safely for section anesthesia. The anesthesia effect of the heateding bupivacaine is faster, the anesthesia level is higher, the anesthesic and muscle relaxant effect is better. Bupivacaine at room temperature has relatively small effect on hemodynamics.
Objective To systematically review the influence of propofol orsevoflurane on postoperative cognitive dysfunction(POCD) in elderly patients undergoing non-cardiac surgery. Methods Eight databases including Cochrane Database of Systematic Reviews, MEDLINE, EMBASE, Pubmed, CNKI, VIP, CBM and Wanfang Database were searched for randomized controlled trials (RCT) about the influence of propofol orsevoflurane on POCD in elderly patients from the time of database establishment to June, 2016. At the same time, the reference materials of included literature were retrieved manually. All data were selected and evaluated by three independent reviewers according to the inclusion and exclusion criterions. RevMan 5.1 was used for the data analysis. Results A total 14 trials were discovered involving 790 elderly patients undergoing non-cardiac surgery. The results of Meta-analysis showed that the eye opening time and extubation time in the propofol group were significant shorter than sevoflurane group[SMDeye opening=-0.83,95%CI(-1.05,-0.61),P<0.05;SMDextubation=-0.85,95%CI(-1.09,-0.62),P<0.05]. The MMSE scores at 1,3 and 6 h respectivelyafter the operation were obviously higher than those of sevoflurane group[SMD1h =0.84,95%CI(0.61,1.08),P<0.05;SMD3 h=1.12,95%CI(0.86,1.38),P<0.05;SMD6h=0.61,95%CI(0.40,0.82),P<0.05]. One day after the operation,the difference was not significant[SMD1d=0.14,95%CI(-0.03,0.31),P>0.05].Three days after the operation, the values returned to normal levels, and was still higher in propofol group than in sevoflurane group[SMD3d=-0.32,95%CI(-0.56,-0.07),P<0.05] until 7 d [SMD7d=-0.18,95%CI(-0.51,0.15),P>0.05]. The odds ratio of POCD incidence between propofol and sevoflurane groups was 0.35 [95%CI(0.21,0.58),P<0.05]. Conclusion Propofol may lead to shorter eye opening time and extubation time compared to sevoflurane in elderly patients undergoing non-cardiac surgery. Both groups may lead to POCD, while propofol is a better choice for elderly patients when choosing general anesthesia.
Objective To screen patients with clopidogrel resistance and develop accurate anti-platelet therapy strategies based on CYP2C19 gene polymorphism. Methods A total of 200 patients with acute coronary syndrome/percutaneous coronary angioplasty were selected. The pyrophosphate sequencing technology was using to detect CYP2C19 gene polymorphism for identifying clopidogrel poor metabolizers and guide antiplatelet therapy according to the development of clopidogrel resistance strategies. Results The proportion of patients with clopidogrel resistance (including intermediate metabolizers and slow metabolizers) was about 63.5%. In clopidogrel intermediate metabolizers, 41.4% cases were applied double dosages of clopidogrel and about 20.2% patients were given ticagrelor instead of clopidogrel. For clopidogrel slow metabolizers, approximately 39.3% cases were given doubled dosage of clopidogrel and 46.4% cases were given ticagrelor. Compared with previous data, the proportion of individual treatment of clopidogrel resistance was significantly increased in this study. Conclusion The strategies for the treatment of clopidogrel resistance, which based on the polymorphism of CYP2C19 gene, have been achieved initial success.
Objective To explore the improvement of minocycline on negative symptoms in patients with schizophrenia and its influence on tumor necrosis factor (TNF)-α. Methods Patients with schizophrenia were randomly assigned into two groups. One was olanzapine combined with placebo group (control group, 37 cases). The other was olanzapine combined with minocycline group (treatment group, 200 mg ·d-1,po,bid, 38 cases). Both groups were assessed by the positive and negative syndrome scale (PANSS), the scale for the assessment of negative symptoms (SANS), and also tested the level of TNF-α before and after 12 weeks treatments. Results After 12 weeks treatments, the scores of SANS and PANSS in treatment group were significantly lower than those of control group (P<0.05). The level of TNF-α in treatment group[(6.5±1.3) pg ·mL-1]was significantly lower than that of control group[(7.6±1.8) pg ·mL-1] (P<0.01). Conclusion Minocycline can improve negative symptoms in patients with schizophrenia, and the mechanism may be related to lower the level of TNF-α.
The content of endogenous anabolic steroids is extremely low in biological matrices.Its chemical structure contains polar functional groups such as hydroxyl and carbonyl, which limits their applicability in GC-MS. The lack of ionized groups in the chemical structure leads to poor sensitivity in LC-MS, which plays a significant role in various physiological activities analysis. It is an effective way to enhance the response of mass spectrometer by modifying the chemical structure of endogenous anabolic steroids through derivatization technology.This review summarizes various derivatization reagents and corresponding derivatization processes of endogenous anabolic steroids analysis in the methods based on different testing instruments and methodologies. The advantage and disadvantage of all kinds of derivatiaztion methods and the prospect of the endogenous anabolic steroids derivatiaztion techniques are also discussed.
Objective To enhance the solubility and bioavailability of curcumin (CUR). Methods A novel curcumin nanoparticles were prepared.The CUR-PGD nanoparticles were prepared by the method of ultrasound precipitation combined with high-pressure homogenization using codendrimer PAMAM-co-0.25OEG (PGD) as stabilizer.The stability of CUR-PGD nanoparticles was measured in 0.9% sodium chloride solution,5% glucose, PBS and plasma. Results The drug loading capacity (DL%) of CUR-PGD nanoparticles was 41.2%, the solubility of CUR was increased to 1.5 mg·mL-1 (50 times of CUR bulk powder).The mean diameter of the nanoparticles was 438.0 nm with spherical morphology and the zeta potential was 41.4 mV.The nanoparticles was stable in 0.9% sodium chloride solution,5% glucose, PBS and plasma and there was no hemolytic phenomenon, which meant they were suitable for intravenous administration.The DSC and XRD spectra of CUR-PGD nanoparticles showed that the CUR was presented as crystal morphology in the nanoparticles.The CUR released from nanoparticles was detected in different releasing medium and presented obvious controlled release behavior. Conclusion PGD may be an effective stabilizer for the preparation of CUR-PGD nanoparticles and CUR-PGD nanoparticles are a promising drug delivery system for CUR application in clinic.
Objective To prepare everolimus self-microemulsifying drug delivery systems (Everolimus-SMEDDS) and evaluate its physicochemical properties. Methods Everolimus- SMEDDS were developed by using rational blends of components with good solubilizing ability for everolimus which were selected based on solubility investigation.Then, pseudo-ternary phase diagram was constructed to determine the self-emulsifying region.The appearance, morphology, particle size distribution, Zeta potential and in vitro drug release behavior of Everolimus- SMEDDS were investigated after being diluted by water. Results An optimal Everolimus-SMEDDS consisting of ethylis oleas, Solutol HS 15 and propylene glycol were identified, and the optimum proportion was 8∶1∶1. Upon mixing with water, Everolimus-SMEDDS formed a clear and transparent microemulsion solution with homogeneous small spherical as seen in transmission electron microscopy. Particle size and Zeta potential of Everolimus-SMEDDS were found to be (48.7±25.1) nm and (-14.2±2.5) mV, respectively. The in vitro release profile indicated that the accumulated release of everolimus in SMEDDS reached up to nearly 100% within 30 min. Conclusion The in vitro dissolution of everolimus was remarkably improved by SMEDDS. It can provide reference for the new dosage form of everolimus.
Objective To investigate celecoxib self-microemulsifying drug delivery system (CXB-SMEDDS) that was developed to increase the dissolution rate and oral bioavailability of celecoxib. Methods The formulation of CXB-SMEDDS was optimized by pseudo-ternary phase diagrams analysis. The appearance, morphology, particle size distribution and in vitro drug release behavior of CXB-SMEDDS were investigated after diluted by water. The bioavailability of CXB-SMEDDS was determined by oral administration to rats compared with CXB suspension. Results An optimized formulation was selected: Medium chain triglycerides as oil phase, Tween 20 as surfactant, Transcutol HP as cosurfactant. The ratio of oil phase, surfactant and cosurfactant was 2∶9∶9. Upon mixing with water, CXB-SMEDDS formed a clear and transparent microemulsion solution with homogeneous small spherical under transmission electron microscopy. For particle size of CXB-SMEDDS was found to be (57.6±14.2) nm. The in vitro dissolution test indicated a significant improvement in release characteristics of CXB. The AUC of CXB-SMEDDS and CXB suspension were (5.54±0.94) and (3.32±0.59) mg·L-1·h, respectively. The relative bioavailability was 166.9%. Conclusion The SMEDDS can significantly increase celecoxib dissolution in vitro and bioavailability in vivo.
Objective To prepare the phmaceutical reference materials of total lactones extract from ginkgo leaf for quantitative analysis. Methods A HPLC determination method was developed to investigate the uniformity and stability of the reference extract of ginkgo leaf total lactones using with bilobalide, ginkgolide A, ginkgolide B and ginkgolide C as the indexes. Three laboratories participated in the collaborative calibration test. Results The four components in reference extract had good uniformity and stability with RSD less than 2.0%; the marked values of the four components had been determined through statistical data analysis which provided by assigned traceability values. The values of bilobalide, ginkgolide A, ginkgolide B, and ginkgolide C were 39.54%, 29.03%, 15.96% and 11.69%, respectively. Conclusion The reference extract of ginkgo leaf total lactones can be prepared for quality control in future quantitative analysis.
Objective To evaluate the efficacy and safety of recombinant human endostatin (rh-endostatin) combined with cis-platinum for patients with malignant pleural effusions. Methods A computer-based online search was performed through Elsevier, PubMed, Medline, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chinese BioMedical Literature Database and Wanfang Database. According to the inclusion and exclusion criteria, the randomized controlled trials about short-term therapeutic effect of rh-endostatin combined with cis-platinum on malignant pleural effusions published until December 2015 were selected. Quality of the studies was assessed using modified Jadad scale. After data extraction, a Meta-analysis was performed by RevMan 5.3 software. Relative risk (RR) and its 95% confidence interval (CI) were calculated. The Egger test was performed by Stata 12.0 software. Results Fourteen eligible randomized controlled trials were included in this Meta-analysis involving 1 330 patients,665 in cis-platinum alone group(control group), and 665 in rh-endostatin combined with cis-platinum group(treatment group). The results showed that there were significant improvements in overall response rate (ORR) [73.53% vs 45.41%,RR=1.62,95%CI(1.47,1.78),P<0.000 01] and the rate of quality of life improvement [71.65% vs 46.94%,RR=1.52,95%CI(1.38,1.68),P<0.000 01] in the treatment group, as compared with those of the control group. Meanwhile, there were no statistically significant differences in the rate of cardio toxicity [10.38% vs 5.77%,RR=1.73,95%CI(0.99,3.03),P=0.06]. Conclusion This Meta-analysis indicated that in comparison with cis-platinum alone, rh-endostatin combined with cis-platinum has a better therapeutic effect on malignant pleural effusions.
Objective To evaluate the effect of clinical pharmacists on cases consultation by retrospective analysis. Methods Seven hundred and thirty-one consultation cases from January 2011 to December 2014 were systematically reviewed, and the clinical department, question classification, organ system of infection, consultation purpose, recommendation variety to infection problems, acception percentage, infection problem outcome were recorded. Furthermore, the typical cases were analysed. Results The number of consultations and clinical departments increased by years, formulating anti-infective therapeutic regimen, determining duration of therapy and drug dosage were the main purposes of consultation. The proportion of infection problems was 86.0%, adoption rate of recommendations was 83.6%, the clinical efficacy rate was 84.3% among them. The proportion of non-infectious problems was 14.0%, adoption rate of recommendations was 100.0%. Conclusion Clinical pharmacists' professional skills are respected by doctors .Anti-infection problem is a breakthrough point for deeply developing the work of clinical pharmacists.
Objective To introduce the working experience of clinical pharmacists who provide pharmaceutical service in participating integrated diabetes out-patient. Methods Review and analyze the patients' clinical features and the clinical pharmacists' working model and effect in integrated diabetes out-patient of the Sixth People's Hospital Affiliated to Shanghai Jiaotong University. Results Among these patients who got pharmaceutical service in integrated diabetes out-patient, 81.7% were 40 to 70 years old, 51.7% had diabetes for 5 to 10 years, 50.0% were taking oral antidiabetic drugs to control blood glucose, and 90.0% were having complications.After the medication guide by clinical pharmacists,patients' medication compliance was increased from the percentage of 30.0% to 80.0%, the good control rate of blood glucose was increased from the percentage of 8.3% to 41.7%, and the incidence rate of adverse reaction was reduced from 10.0% to 3.3%. Conclusion Clinical pharmacists who actively participate in integrated diabetes out-patient could ensure the effective and safe treatment to diabetic patients. Therefore, this model is worth to be popularized due to professional value of clinical pharmacists.
Objective To investigate the incidence and risk factors of adverse drug reactions in hematological system induced by linezolid. Methods In this retrospective study, 124 inpatients treated with linezolid (n=62) or vancomycin (n=62) for anti-infective therapy between January 2012 and December 2015 in clinical departments of the Second Affiliated Hospital of Anhui Medical University were included. The incidence hematological adverse drug reactions were observed, and the single factor and the multiple factor Logistic regression methods were used to analyze the risk factors of developing thrombocytopenia and decline of hemoglobin. Results Among the 62 inpatients treated with linezolid, thrombocytopenia occurred in 21 patients(33.87%), and decline of hemoglobin occurred in 17 patients (27.42%). No patient discontinued the use of linezolid for the reason of thrombocytopenia or decline of hemoglobin. In multiple stepwise regression analysis, linezolid use[OR=7.699,95%CI (1.408,42.090),P=0.019], treatment duration>14 d[OR=7.639,95%CI(1.162,50.226),P=0.034], baseline eGFR<80 mL·min-1[OR=6.150,95%CI(1.604,23.577),P=0.008], baseline ALB<25 g·L-1[OR=4.078,95%CI(1.017,16.351),P=0.047] and baseline platelet count<200×109·L-1[OR=6.148,95%CI(1.705,22.172),P=0.006] were independent risk factors for thrombocytopenia; linezolid use [OR=4.335,95%CI(1.308,14.365),P=0.016] and baseline ALB<25 g·L-1[OR=5.424,95%CI(1.824,16.129),P=0.002] were independent risk factors for the decline of hemoglobin. Conclusion The incidences of thrombocytopenia and anemia induced by linezolid are not rare, and most of them can be returned to normal. The risk factors of thrombocytopenia and anemia should be concerned and the routine blood test should be monitored during use.
Objective To explore the role of Joint Commission International(JCI) standards on the improvement of pharmaceutical care in pharmacy intravenous admixture service (PIVAS) during the JCI accreditation. Methods The changes of PIVAS in Huangshi Central Hospital were analyzed and compared during JCI accreditation in respect of facilities,software management,service processes,safety awareness of the PIVAS staff and pharmacy management,service evaluation,error rate,etc. Results After JCI accreditation,the process of PIVAS were optimized,the software were updated ,and the safety awareness of PIVAS staff was improved;the management of high alert drugs was implemented more strictly;more importance was attached to the details of pharmaceutical care;the satisfaction degree of the clinic units to PIVAS was increased from 87.0% in 2014 to 98.0% in 2015;error rate was decreased from 0.40‰ in 2014 to 0.15‰ in 2015.The incidence rate of defective product was decreased from 0.32‰ in 2014 to 0.07‰ in March 2015. The correct rate of medical waste classification treatment was increased from about 85.5% in 2014 to 100.0% in 2015.Hand hygiene compliance rate and correct rate were increased up to 100.0%. 6S site management activity participation rate was increased up to 100.0%. Conclusion The application of JCI standards and the process of JCI accreditation improve the quality of pharmaceutical care in hospital PIVAS. It can improve the medical safety in hospital.
