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Effects of Quetiapine Fumarate on Psychological and Behavioral Symptoms of 48 Cases of Patients with Alzheimer’s Disease
Zilei GUO,Yong LIN
Herald of Medicine    2018, 37 (10): 1203-1206.   DOI: 10.3870/j.issn.1004-0781.2018.10.012
Abstract   HTML   PDF (1116KB)

Objective To study clinical application and safety of quetiapine fumarate in treating Alzheimer’s disease (AD). Methods A total of 74 patients with AD were randomly divided into treatment group(n=48)and control group(n=26).Patients in the control group were given 5 mg·d-1 of donepezil chloride,patients in the treatment group were given 5 mg·d-1 of donepezil chloride and 12.5 mg·d-1 of quetiapine fumarate.Before and 1,2,4,8 and 12 weeks after the treatment,the patients were evaluated by mini-mental state examination(MMSE),the brief psychiatric rating scale(BPRS),neuropsychiatric inventory(NPI),NPI distress factor and activity of daily life(ADL). Results After 1 week of treatment,total NPI score of treatment group and control group was(72.830±10.45) and(78.057±10.97),respectively;NPI distress factor was(30.532±5.82) and(34.208±6.50),respectively(all P<0.05).After 4 weeks of treatment,BPRS scores of treatment group and control group was(30.277±6.43) and(35.01±7.38),respectively(P<0.05).After 8 weeks of treatment,NPI distress factor of treatment group and control group was(23.021±5.74) and(28.618±6.08)(P<0.05).After 12 weeks,MMSE score of treatment group and control group was(7.83±3.02) and(7.116±2.67),which was increased compared with that before treatment(all P>0.05). Conclusion Short-term use of quetiapine fumarate can reduce anguish of AD tender,and relieve psychological and behavioral symptoms of AD patients,and may have positive effects on cognitive function.

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Herald of Medicine    2019, 38 (7): 975-983.   DOI: 10.3870/j.issn.1004-0781.2019.07.032
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null    2012, 31 (3): 392-394.   DOI: 10.3870/yydb.2012.03.045
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Preparation Process of Compound Xiecao Shuxin Dropping Pills
ZHOU Conghui,YI Ailing,LIN Yuanyuan,YE Chunsheng,SUN Wanjin,XIONG Yitao
Herald of Medicine    2020, 39 (10): 1409-1412.   DOI: 10.3870/j.issn.1004-0781.2020.10.017
Abstract   HTML   PDF (1145KB)

Objective To study the preparation process of compound Xiecao shuxin dropping pills. Methods Dropping pills were prepared by dropping method.The effects of PEG4000/6000 matrix, drug-matrix ratio, dropping acceleration and liquid temperature on the preparation of the dropping pills were studied.Orthogonal test was conducted with the total scores of appearance, weight difference, and dissolution time as the factors to optimize the best preparation process of compound Xiecao shuxin dropping pills. Results The optimal preparation process of compound Xiecao shuxin dropping pill was as follows: PEG4000/6000 (1:1) was as the matrix, and the ratio of drug to matrix was 1:3.The temperature of the feeding liquid was 90 ℃, and the dropping acceleration was 35 drops per minute, and the temperature range of condensate liquid paraffin was from 5 to 15 ℃. Conclusion The optimized preparation technology is stable and feasible, which can provide necessary reference for the preparation of compound Xiecao shuxin dropping pills.

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Herald of Medicine    2019, 38 (2): 135-146.   DOI: 10.3870/j.issn.1004-0781.2019.02.001
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Acute Toxicity Test of Total Flavoids from Rhizome of Drynariae
ZHAO Jinning;XIE Yanming;ZHANG Wenjun;WANG Zhi;LIU Yuqi
null    2005, 24 (1): 0-0.   DOI: null
Abstract   PDF (98KB)
ObjectiveTo provide evidence for clinical trial and to evaluate the safety of total flavonoids from rhizome of drynariae MethodsThe maximum tolerance of gastrogavage in mice: twenty mice were fed 30 mL·kg-1 with the total flavonoids solution (0.40 g·mL-1 ) by gastrogavage, the bite and sup, activity, psychosis, coat and skin, urine and faeces, and body weight were observed The maximum tolerance of gastrogavage in rats: twenty rats were given the same dose total flavonoids solution, and the same observation were done The acute toxicity trial in mice, LD50 was carried out by abdominal injection with 7 dosage groups, and the mice were observed for 7 days after one injection ResultsThe mice and rats had no abnormal changes in bite and sup, activity, psychosis, coat and skin, urine and faeces, and body weight There were no significant changes(P>0.05) Only a little remain of the fed sample was found in the abdomen anatomizing And there were no remarkable pathological changes in all organs The median lethal dose of the total flavonoids was 5.99 g·kg-1 ConclusionThere are no abnormal changes in the acute toxicity trial with total flavonoids from rhizome of drynariae, and the flavonoids are safe in clinical use
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Gatifloxacin Hydrochloride in the Treatment of 114 Patients with Infections of the Respiratory or Urinary System
ZHANG Jianchu;XIN Jianbao;YANG Weibing;XIONG Xianzhi;LI Hong;JIN Yang;ZHANG Xiaoju;GUO Yi
null    2006, 0723 (8): 773-0774.   DOI: null
Abstract   PDF (1058KB)
To assess the therapeutic effectiveness and safety rate of gatifloxacin hydrochloride in the treatment of infections of the respiratory or urinary system. Methods225 patients with infections of the respiratory or urinary system were randomly divided into 2 groups: the trial group (n=114) and control group (n=111). Patients of the trial group were given each 0.4 g of gatifloxacin hydrochloride tablets PO,q.d. while those of the control group were given each 0.2 g of levofloxacin, PO, b.i.d.. The course of treatment in both groups lasted 7-14 days. The therapeutic effectiveness and adverse reactions of the drugs were kept under observation. ResultsIn patients of the trial group and control group, the clinical effective rates were 88.60% and 92.79%, the bacteria elimination rates were 94.32% and 96.63% and the incidences of adverse reactions were 9.32% and 11.97%, respectively. Differences between the 2 groups with respect to the above mentioned data were insignificant (P>0.05). ConclusionGatifloxcin hydrochloride was shown to be effective and safe in the treatment of infections of the respiratory or urinary system.
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Comparison of Therapeutic Effects between Mirtazapine and Alprazolam on Chronic Insomnia
LI Qiongzhi;JIANG Jinxiang
null    2006, 25 (9): 907-0908.   DOI: null
Abstract   PDF (1148KB)
To determine whether mirtazapinne is clinically effective on the treatment of chronic insomnia and to compare the clinical effects between mirtazapine and alpazolam on chronic insomnia. MethodsSeventynine patients were randomly divided into two groups (38 and 41 for each), which received the treatments of mirtazapine and alprazolam respectively for 12 weeks as a course. The patients in mirtazapine group took 10-15 mg 0.5 hour before sleeping, while the patients in alpazolam group took 0.4-0.8 mg 0.5 hour before sleeping. The curative effects were evaluated with Pittsburgh Sleep Quality Index (PSQI) and sleeping dairy before and after the 4th, 8th, and 12th weeks of treatment. ResultsThe effective rate and significantly effective rate of mirtazapine on chronic insomnia were 96.9% and 90.6%, respectively, whereas those of alprazolam, 78.8% and 51.5% respectively. Mirtazapine played significantly better role in the treatment of chronic insomnia than alprazolam did(P<0.05). The side effects of mirtazapine included sleepy, dizzy and getting weight, all of which were acceptable. ConclusionMirtazapine is surely effective on clinical treatment of chronic insomnia with mild side effects . For using mirtazapine, starting with the small dosage is suggested.
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Effect of Ceftazidine on Aminophylline Pharmacokinetics in Rat
CAI Aijun;SU Xigai;JIN Shumin;LIU Zengjuan
null    2005, 24 (1): 0-0.   DOI: null
Abstract   PDF (98KB)
ObjectiveTo study the effect of ceftazidine on aminophylline pharmacokinetics in rats. MethodTwelve rats fasting for 12 h were randomized into two equal groups. The control group were given 18 mg.kg-1 of aminophylline intragastrically, and the test group were given 18 mg·kg-1 of aminophylline intragastrically and 100 mg·kg-1 of ceftazidine, i.m.. The concentration of theophylline in rat serum was detected at 0, 0.08, 0.50, 1.00, 2.00, 4.00, 6.00, 8.00, 12.00 hours by FPLA.ResultsTheophylline was eliminated by one compartment model. The pharmacokinetics parameters had no significant difference between the two groups.ConclusionCeftazidine has no effect in the metabolism of aminophylline.
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null    2006, 0723 (8): 836-0836.   DOI: null
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Effect of Radix Astragli Injection Combined with Puerarin Injection on Urine Microprotein in Treatment of Type 2 Diabetic Nephropathy
YU Junping;WANG Jiru;FANG Ming;CHEN Xia;HE Liying
null    2005, 24 (1): 0-0.   DOI: null
Abstract   PDF (97KB)
ObjectiveTo observe the therapeutic effects of puerarin injection combined with radix astragli injection on urine microprotein in patients with type 2 diabetic nephropathyMethodsSeventyeight patients with type 2 diabetic nephropathy randomised into the treatment group (41 cases) and the control group (37 cases). The control group were treated with radix astragli injection 30 mL·d-1, iv, gtt, qd, and the treatment group received the same medicine combined with puerarin injection 500 mg·d-1 iv, gtt, qd. Both groups were treated for 2 weeks. The parameters of blood plasma such as TC, TG, PAGT, FIB and UAER were tested before and after the treatment.Results In the treatment group, the average values of the tested parameters were decreased significantly after the treatment than before the treatment (P<0.05 or P<0.01) Except TC and LDL-C, the average values of the tested parameters were also lowered significantly in the treatment group than in the control group (P <0.05 or P <0.01). ConclusionPuerarin injection can lower the blood lipids, improve blood viscosity, and decrease urine protein. The combination of puerarin injection with radix astragli injection has better effect than radix astragli injection alone in the treatment of type 2 diabetic nephropathy.
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null    2006, 25 (1): 0-0.   DOI: null
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102 Cases of Acute Upper Respiratory Infection Treated with Lianhuaqingwen Capsule
HU Ke;JIANG Yan;SHI Meijun;HU Chunhua;LIU Zhenlian;WAN Zhihui
null    2008, 27 (11): 1337-1340.   DOI: null
Abstract   PDF (1308KB)
ObjectiveTo evaluate the efficacy and safety of lianhuaqingwen capsule for treating acute upper respiratory tract infection. MethodsThe clinical randomizedcontrolledtrails were conducted. VitC yinqiao tablets was used as control. A total of 206 subjects with acute upper respiratory tract infection were enrolled in our study, in which 102 patients randomly assigned in the treatment group were orally given lianhuaqingwen capsule (4 capsules, tid) for 3 d, and the other 104 patients were orally administered with VitC yinqiao tablets (2 pills,tid) for 3 d. ResultsThe clinical efficacy rates were 91.2% and 73.1% in lianhuaqingwen capsule group, and VitC yinqiao tablets group, respectively. Compared with control group, lianhuaqingwen capsule was more effective for improving main symptoms including fever, chill, headache and myalgia, with the therapeutic rates for whjch were 90.2%,85.4%,89.5%,91.0%, respectively. No significant difference on incidence of side effects in both groups was found (P>0.05). ConclusionThe results suggest that lianhuaqingwen capsule is an effective and safe agent for treating acute upper respiratory tract infection, and is superior to VitC yinqiao tablets.
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Effect of Glycoside of Tripterygium wilfordii hook.F on Expression of Receptor Activator of Nuclear FactorκB Ligand and Osteoprotegerin in Joints of Rat Adjuvant Induced Arthritis
LUO Bo;HU Yonghong;ZHANG Mingmin;TU Shenghao;ZENG Keqin
null    2006, 25 (5): 0-0.   DOI: null
Abstract   PDF (1184KB)
ObjectiveTo explore the effect of Glycoside of tripterygium wilfordii hook(GTW) on the expression of receptor activator of nuclear factorκB ligand(RANKL) and osteoprotegerin(OPG) in the joints of rat adjuvant induced arthritis(AA). MethodsAA was induced in Wistar rats. Arthritis rats were orally given GTW and methotrexate(MTX) at the onset(day 0) of arthritis. On the peak of arthritis(day 24) the expression of RANKL and OPG in the joints were analyzed using specific immunohistochemistry and image analysis. Bone mineral density (BMD) at the distal end of femoral bone was also evaluated.ResultsCompared with AA control (model)group, Arthritis rats treated with GTW and MTX have higher BMDP<0.05) and lower levels expression of RANKL in synovium, subchondral and trabecular bone(P<0.01,P<0.05)respectively. And OPG level is lower than AA group in subchondral and trabecular bone(P<0.05).ConclusionGTW and MTX may inhibit RA bone erosion by decreasing the expression of RANKL in inflammatory joints.
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null    2006, 25 (5): 0-0.   DOI: null
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null    2006, 25 (5): 0-0.   DOI: null
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Study on Preparation and Quality Standard of Ibuprofen Gel
FANG Jianguo;WANG Wenqing;WANG Qiulan;MA Yonggui;SHI Chunyang;TANG Jie
null    2006, 25 (1): 0-0.   DOI: null
Abstract   PDF (1117KB)
Objective To study the preparation and quality standard of ibuprofen gel. MethodsCarbomer 940 and other supplementary materials were used to prepare ibuprofen gel,and a reverse phase high performance liquid chromatography (RPHPLC) was established to determine its content and other substances by using a chromatograph column: Lichrosorb C18 column(4.6 mm×150 mm,5 μm),mobile phase: acetonitrilewater (58∶42) (pH adjusted to 3.0 with phosphoric acid)with a flow rate of 1.0 mL·min-1 and detection wavelength at 264 nm.Results The standard curve was linear in the range of 50.02-400.16 μg·mL1 (r=0.999 9).The average recoveries (n=9)were 99.0%(RSD=0.44%),100.5%(RSD=0.56%),99.2%(RSD=0.35%),respectively. ConclusionThe materials such as carbomer can prepare the ideal ibuprofen gel with a standard and reliable quality.
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null    2005, 24 (1): 0-0.   DOI: null
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null    2006, 25 (7): 0-0.   DOI: null
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Optimization of Extraction for Flavonoids from Coreopsis Tinctoria Nutt.by Response Surface Methodology
Xincheng YAO,Heng WANG,Ruikun SHI,Beibei WANG,Hui TANG
Herald of Medicine    2016, 35 (7): 765-769.   DOI: 10.3870/j.issn.1004-0781.2016.07.022
Abstract   HTML   PDF (1614KB)

Objective Response surface methodology (RSM) was applied to optimize the ultrasonic extraction conditions for flavonoids from Coreopsis tinctoria Nutt. Methods The influence factors of ultrasonic extraction were evaluated using the Box-Behnken central component experiments and analyzed by RSM. Results The optimum extraction conditions were confirmed as follows:extraction time 30.0 min, ratio of liquid to solid 21:1, concentration of ethanol 60%.The yield of flavonoids under this condition was (4.65±0.036)% (n=3). Conclusion The flavonoids could be extracted with stability and higher yield from Coreopsis tinctoria Nutt under optimized conditions.

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Costeffectiveness Analysis of 3 Drugs for the Treatment of Ulcerative Colitis
SHOU Zhangxuan;JIN Xue;RUAN Hongjun
null    2006, 25 (5): 0-0.   DOI: null
Abstract   PDF (1266KB)
ObjectiveTo evaluate the economic effectiveness of 3 drugs for the treatment of ulcerative colitis.MethodsA total of 62 ulcerative colitis outpatients was randomly allocated into 3 groups as given sulfasalazine(A)、mesalazine(B)and olsalazine sodium (C), respectively. A costeffectiveness analysis was performed under the principles of pharmacoeconomics. ResultsThe costeffectiveness ratios( C/E )of 3 drugs were 17.47,28.14 and 21.20, respectively. Compared with A ,the incremental costeffectiveness ratios(ΔC/ΔE )were 48.96 for B and 27.77 for C .ConclusionAmong 3 drugs, olsalazine sodium is the optimal drug for the treatment of ulcerative colitis.
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Effects of Astragalus Injection on Renal Ischemia Reperfusion Injury in Rats
YAN Bin;NIU Qian;NAN Xiaodong;LAI Zhengu;FU Jiewu;ZHANG Xudong
null    2006, 25 (1): 0-0.   DOI: null
Abstract   PDF (1111KB)
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Clinical Efficacy of Levodropropizine in Cough Treatment
TAO Xiaonan;XIN Jianbao;ZHANG Xiaoju;LI Yiming;XIONG Xianzhi;BAI Ming
null    2005, 24 (1): 0-0.   DOI: null
Abstract   PDF (70KB)
Objective To evaluate the efficacy and safety of levodropropizine in cough treatment. MethodsFifty patients with nonproductive cough were randomly divided into two groups for a doubleblind control study The treatment group received levodropropizine 10 mL, po, tid, and the control group received dextromethorphan 10 mL, po, tid. All the patient were treated for 5 days.Results The clinical effective rates in the treatment group and in the control group were 69.56% and 61.90% , respectively(P>0.05), in severer cough treatment were 93.33% and 69.23%, respectively (P< 0.05). The adverse reaction rates in the treatment group and in the control group were 23.07%and 41.67%, respctively (P>0.05).ConclusionLevodropropizine is safe and effective in cough treatment
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Treatment of 31 Cases of Schizophrenia with Quetiapine
XIANG Dongfang;LIU Xiaolin
null    2005, 24 (1): 0-0.   DOI: null
Abstract   PDF (88KB)
Objective To compare the efficacy and safety of quetiapine with clozapine in treatment of patients with schizophrenia. MethodSixtyone patients with schizophrenia were randomised into two groups, thirty patients treated with clozapine and thirtyone treated with quetiapine. positive and negative symptom scale(PANSS) and treatment emergent symptom scale(TESS) were used to assess efficacy and safety before treatment and at the end of 1, 2, 4 and 8 week.ResultsThe PANSS scores in both groups decreased significantly after the treatment, and there is no significant difference between the two group (P>0.05), but the quetiapine grouup had less adverse drug reaction (P<0.01). ConclusionQuetiapine has similar efficacy with clozapine in treating schizophrenia, but has less adverse drug reaction than clozapine.
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Effect of Astragalus for Injection on Serum Level of Interleukin10 in Children with Idiopathic Nephrotic Syndrome
LIN Feijin;GAO Yan;CHEN Shumei;ZHAO Jizong;HUANG Jincheng;CUI Minxian
null    2006, 25 (5): 0-0.   DOI: null
Abstract   PDF (1254KB)
ObjectiveTo detect the effect of astragalus for injection together with glucocorticoid on serum levels of IL-10 in children with idiopathic nephrotic syndrome(INS), to analyse their role in INS and the mechanism of astragalus' treatment for INS. MethodsSixtythree children with idiopathic nephrotic syndrome were divided into astragalus group including thirtythree cases and nonastragalus group including thirty cases. In astragalus group, patients were given prednisone 1.5-2.0 mg·kg-1·d-1,P.O., qd, astragalus for injection 0.5 mL·kg-1·d-1, and other symptomatic treatments. In nonastragalus group except astragalus for injection, other treatments were the same as the first group. The serum IL10 levels in all patients between initial stage and one month after therapy were detected. Other 25 healthy children were collected in control group. Serum IL10 levels were detected by a double antibody "sandwich" ELISA. ResultsIn initial stage, there was no significant difference in serum IL10 level between nonastragalus group and astragalus group (14.05±5.57) pg·mL-1 vs (13.39±6.14) pg·mL-1(t=0.61,P>0.05), and both were higher than control group [(14.05±5.57) pg·mL-1 vs (9.48±4.01) pg·mL-1, t=3.36, P<0.01, and (13.39±6.14) pg·mL-1 vs (9.48±4.01) pg·mL-1, t=2.77, P<0.01]. Serum IL-10 levels in nonastragalus group after prednisone therapy were significantly lower than those before prednisone therapy (9.36±3.43) pg·mL-1 vs (14.05±5.57) pg·mL-1, t=3.55, P<0.01, and no significant difference was observed as compared with control group. Compared with those before treatment, Serum IL-10 levels in astragalus group were not significant different in initial stage and one month after prednisone together with astragalus therapy(t=0.95,P>0.05. Serum IL10 levels of astragalus group in one month after prednisone together with astragalus therapy were still significantly higher than those in control group(12.10±4.14) pg·mL-1 vs (9.48±4.01) pg·mL-1, t=2.25,P<0.05 and nonastragalus group in one month after prednisone therapy(12.10±4.14) pg·mL-1 vs (9.36±3.43)pg·mL-1, t=2.40,P<0.05).ConclusionAstragalus for injection can prevent the lowering of serum IL-10 levels in children with idiopathic nephrotic syndrome and counteract the inhibitory effect of hormone on the production of IL-10. This may be one of the mechanism of astragalus for injection to lower the urine protein content in children with INS.
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Relationship of Polymyxins Between Intrapulmonary Concentration and Blood Concentration in Patients with Ventilator-associated Pneumonia
Yin HUANG,Cheng CHEN,Jiao YANG,Yong YANG
Herald of Medicine    2018, 37 (10): 1256-1261.   DOI: 10.3870/j.issn.1004-0781.2018.10.027
Abstract   HTML   PDF (1213KB)

Objective To explore the relationship between intrapulmonary concentration and blood concentration of polymyxin in patients with ventilator-associated pneumonia. Methods The pharmacological effects of polymyxins were reviewed.Detection and calculation methods for the polymyxin concentration in lung tissue were introduced.The intrapulmonary concentration,blood concentration and lung tissue penetration of polymyxins in patients with ventilator-associated pneumonia were summarized.The relationship between intrapulmonary concentration and blood concentration was analyzed. Results When polymyxin was administered intravenously,the concentration was significantly lower in epithelial lining fluid than in the blood,or even below the detection limit; however,when polymyxin was administered by inhalation,the drug concentration in the lung was increased significantly,and the drug concentration in epithelial lining fluid could reach 100 to 1000 times over blood concentration.The greater the dose of intravenous infusion or aerosol inhalation was administered,the higher the concentration of polymyxins in the blood and lung tissue. Conclusion In the treatment of ventilator-associated pneumonia,more attention should be paid to the intrapulmonary concentration of polymyxins in patients,and adjustment of the administration route can help make the clinical use of polymyxins more effective.

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The Clinical Effect of Yuxingcao Nasal Drops to Zcute and Chronic Rhinitis
YOU Xuejun;FANG Jianguo;LIU Zheng;ZHEN Hongtao;GAO Qixue;CUI Yonghua;TAO Yanling
null    2007, 26 (11): 1310-1313.   DOI: null
Abstract   PDF (1240KB)
ObjectiveTo investigate the clinical effect and safety of using yuxingcao nasal drops to treat acute and chronic rhinitis. MethodsTotally, 376 patients who suffer from acute or chronic rhinitis were recruited, including 142 patients with acute rhinitis, 138 patients with chronicsimple rhinitisand 96 patients with chronic hypertrophic rhinitis, scoring method was employed to invest the difference before and after the treatment. ResultsAfter using yuxingcao nasal drops, the patients’signs and symptoms general score was decreased, while the signs and symptoms general score of acute rhinitis and chronic simple rhinitis showed extremely significant difference before and after the treatment (P<0.01), the decrease rate was 82.3% and 80.7% respectively, effective rate was 100%. The signs and symptoms general score of chronic hypertrophic rhinitis showed significant difference before and after the treatment ( P<0.05 ), the decrease rate was 76.8%, effective rate was 100%. No side effect was observed during the treatment.ConclusionThe yuxingcao nasal drops was effective and safety to treat patients with acute and chronic rhinitis, no allergic reaction or bad event was occurred, it worth to be recommendin clinical treatment.
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null    2006, 25 (2): 0-0.   DOI: null
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Effect of Pharmacist-led Intervention on Mastery of Inhalation Technique for Patients
Qiuhui WU,Guifan ZHANG,Jingjing ZHANG,Weihong GE
Herald of Medicine    2019, 38 (3): 333-336.   DOI: 10.3870/j.issn.1004-0781.2019.03.010
Abstract   HTML   PDF (1152KB)

Objective To investigate the influence of pharmacist-led intervention on the mastery of inhalation techniques for patients with asthma/COPD. Methods The inhalation technique assessment form was used to assess the patient mastery of inhalation technique.The patient mastery of inhalation technique after the pharmacist’s face to face intervention was compared to find the effect of pharmacist intervention on inhalation techniques. Results With pharmacist intervention, the frequency of patient making mistakes in using different devices was significantly decreased.The frequency of making mistakes in using Symbicort Turbuhaler and HandiHaler for each patient decreased from 3.22 to 0.65, and from 3.20 to 0.56, respectively. Conclusion The patients with asthma and COPD poorly mastered inhalation technique.Pharmacists intervention has definite effect on the correct use of inhalation device.It is necessary for pharmacists to evaluate the mastery of inhalation technique for patients with asthma/COPD.

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null    2006, 25 (5): 0-0.   DOI: null
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