LI Qi, YANG Rou, SHEN Xiaoyan, ZHOU Xiaoshi, LI Guolin, ZHANG Changji, YANG Yong
Objective For more focused prevention and management, this investigation examines the risk factors for multidrug resistant organisms (MDRO) infections in intensive care unit (ICU) patients. Methods Case-control studies and cohort studies of risk factors for MDRO infection in ICU patients were searched in the Embase, Website of Science, Cochrane Library, PubMed, CNKI, WanFang, and VIP databases from their start to October 26, 2022. The Meta-analysis was carried out with RevMan 5.3. Results A total of 32 papers were included, with 10 985 cases studied, with the quality of the literature rated as moderate to high. The results of Meta-analysis of this study showed that gender [OR=1.21, 95%CI=(1.08,1.36), P=0.002], ICU length of stay [WMD=5.36, 95%CI=(3.99,6.73), P<0.000 01], total length of stay [WMD=8.96, 95%CI=(6.51,11.41), P<0.000 01], hypertension [OR=1.33, 95%CI=(1.10,1.60), P=0.003], abnormal renal function [OR=1.69,95%CI=(1.33,2.16), P<0.000 01], hypoproteinemia [OR=1.87,95%CI=(1.51,2.32), P<0.000 01], mechanical ventilation [OR=2.26,95%CI=(1.18,4.33), P=0.01], duration of mechanical ventilation [WMD=8.83,95%CI=(2.52,15.14), P=0.006], arteriovenous placement [OR=1.46,95%CI=(1.23,1.72), P<0.000 1], placement of urinary catheter [OR=1.71,95%CI=(1.25,2.36), P<0.000 01], gastrointestinal tube placement [OR=0.10,95%CI=(0.03,0.18), P=0.008], antimicrobial drug type ≥3[OR=4.27,95%CI=(2.06,8.85), P<0.000 01], use of carbapenem antibiotics [OR=4.09, 95%CI=(300,5.58), P<0.000 01], the use of the third-generation cephalosporin[OR=1.63, 95%CI=(1.15,2.33), P=0.007], the use of quinolone antibacterials [OR=1.86,95%CI=(1.42,2.44), P<0.000 01], the use of aminoglycoside antibiotics[OR=1.99, 95%CI=(1.49,2.67),P<0.000 01], use of piperacillin-tazobactam [OR=2.94, 95%CI=(1.56,5.54), P=0.000 9], use of glycopeptide antibiotics [OR=3.78, 95%CI=(2.48,5.78), P<0.000 01], use of sedatives [OR=3.25,95%CI=(2.06,5.14), P<0.000 01], and use of acid suppressants [OR=1.51,95%CI=(1.06,2.16), P=0.02] are risk factors for MDRO infection in ICU patients. Conclusion MDRO infections in ICU patients are associated with gender, duration of ICU stay, chronic lung disease, total length of stay, hypertension, abnormal renal function, hypoproteinemia, mechanical ventilation, duration of mechanical ventilation, arteriovenous placement, placement of urinary catheters, gastrointestinal placement, type of antimicrobial drugs≥3, use of carbapenem antibiotics, use of third-generation cephalosporin, use of quinolone antibacterials, use of aminoglycoside antibiotics, use of piperacillin-tazobactam, use of glycopeptide antibiotics, use of sedatives, use of acid suppressants, and other factors. Targeted controls of different factors such as underlying diseases, comorbidities, invasive procedures performed, and the use of antimicrobial medications and other therapeutic pharmaceuticals could limit the risk of infection in MDRO in ICU patients.