药物研究
BAI Jia-li;YU Cheng-cheng;WANG De-zhi;HAO Jian-xiu;SHEN Xiu;WANG Hao;LIU Xiao-qiu;LONG Wei;ZHOU Ze-wei
Objective To compare the anti-radiation effect between pterostilibene and resveratrol in equimolar oral doses on ICR mice. Methods ICR mice of 6–8 weeks were selected to receive whole body irradiation of 6.5 Gy γ-ray.The mice were randomly divided into six groups to receive the following treatment:Control group, 0.05% CMC-Na; positive control group, rubidate 100 mg.kg-1 ; low- and highdose resveratrol groups, resveratrol at 50 or 150 mg.kg-1 ; low- and high-dose pterostilibene groups, pterostilibene at 56 or 168 mg.kg-1.The mice of the above groups were administered intragastrically 3 days, 2 days, and 1 day before the radiation.After the radiation, the mice were administered intragastrically for 5 consecutives days.The thymus, liver, spleen, lung and bilateral femurs were weighed to calculate corresponding organ indexes.White blood cell count (WBC), blood platelet (PLT), bone marrow nucleated cells (BMNC) and bone marrow DNA were determined, so as to evaluate the radiationprotective effect of pterostilibene and resveratrol. Results Compared with control mice, the indicators of all experiment groups were increased and most have significant difference (P<0.05); the antiradiation effect of pterostilibene was better than resveratrol at the same equimolar oral dose, with significant difference between the lowdose pterostilibene (56 mg.kg-1 ) group and the lowdose resveratrol (50 mg.kg-1 ) group. Conclusion Pterostilibene has better antiradiation effect on ICR mice than resveratrol, and the antiradiation effect of pterostilibene at 56 mg.kg-1 is the best.