Archive

• 01 January 2013 Volume 32 Issue 1

    

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  药物研究
  抗感染药物专栏
  药物与临床
  药物制剂与药品质量控制
  用药指南
  

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药物研究
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  药物研究

  Biodistribution and Metabolic Pathway of Interferon-α1b Administered by Aerosol Inhalation in Rabbits

  LIU Jian-feng;LIU Jin-jian;CHU Li-ping;WANG De-zhi;YU Jia;LIU Jin-yi

  2013, 32(1): 1-5. https://doi.org/10.3870/yydb.2013.01.001

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  Objective The variety on distribution and metabolism between aerosol inhalation and intramuscular injection of interferonα1b(IFNα1b) in rabbits were studied.The priority of IFNα1b administration via aerosol inhalation was investigated. Methods The IFNα1b was labeled with iodine125 and new Zealand white rabbits were used.The ¹²⁵I-IFNα1b was administered via aerosol inhalation, with intramuscular injection as control.Blood was collected at different time and drug concentration in blood was detected by Gamma counter, the drug distribution in different part of lung and metabolic tissues like liver and kidney was imaged by in vivo imaging system and detected by Gamma counter. Results The drug concentration was higher and drug residence time was longer in lung after administered via aerosol inhalation than those with intramuscular injection.The blood drug concentration reached maximum after being administered for 8 hours, and which significantly prolonged.But the drug concentration in kidney was kept at low level within detected time. Conclusion The interferonα1b administered via aerosol inhalation keeps higher drug concentration in lung and longer circulation time in body, comparing with the conventional intramuscular injection, which suggests that the aerosol inhalation may be a more effectively administered way for treating lung disease.
  
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  药物研究

  Effects of Montelukast on Muc5ac Expression in Lung of Asthmatic Mice

  ZHOU Min;CHEN Hui-long;CHEN Sheng;MEI li;ZHANG Hui-lan;XIE Min;XIONG Wei-ning;XU Yong-jian

  2013, 32(1): 5-8. https://doi.org/10.3870/yydb.2013.01.002

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  Objective To study effects of leukotriene receptor antagonist montelukast on the expression of mucoprotein Muc5ac in lung and IL13 secretion in bronchoalveolar lavage fluid (BALF) of asthmatic mice and investigate the possible mechanism. Methods Eighteen BALB/c mice were randomly divided into the control, asthmatic model and montelukast groups, 6 mice in each group.The expressions of Muc5ac protein in lung were detected by immunohistochemical assay.Interleukin-13 level in BALF were analyzed via ELISA. Results The Muc5ac expression in asthmatic group(0.572±0.028)was significantly upregulated compared with control group (0.137±0.041,P<0.01).Muc5ac protein in the montelukast treated group (0.497±0.054) was evidently lower than that of the asthmatic group(P<0.05).The level of IL-13 in BALF in the asthmatic group(78.07±6.78) pg.mL^-1 was obviously increased compared with the control group(28.58±12.98) pg.mL^-1 ,P<0.01, while, which in the montelukast group(51.2±3.53) pg.mL^-1 was distinctly lower than that of the asthmatic group (P<0.01).Muc5ac protein expression was positively correlated to the level of IL-13(r＝0.861,P<0.05). Conclusion Montelukast plays a therapeutic role in mucus hypersecretion of asthmatic airway, which is associated with down-regulation of Muc5ac and IL-13.
  
  
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  药物研究

  Protection of Thymoquinone Against Oxidative Stress and Hepatic Injury After Biliary Ligation in Rats

  KONG Ling-yu;WANG Wen-juan;XI Zan

  2013, 32(1): 9-12. https://doi.org/10.3870/yydb.2013.01.003

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  Objective The aim of this study was to investigate the preventive and therapeutic effect of thymoquinone against oxidative stress and hepatic injury after biliary ligation in rats. Methods A total of 32 Sprague–Dawley rats were randomly divided into 4 groups: normal control, model control, low-dose and high-dose thymoquinone groups.Each group contained 8 animals.The rats in thymoquinonetreated groups were given with thymoquinone (25 or 50 mg.kg^-1 body weight) orally for 2 weeks starting 3 days prior to bile duct ligation.The content of hydroxyproline (HP), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase(GPx) in hepatic tissues was determined.Histopathological examination of liver was carried out. Results Thymoquinone treatment significantly decreased the elevated HP content, and MDA levels and raised the lowed level of SOD, and GPx enzymes in the tissues (P<0.05).Thymoquinone attenuated necrosis and inflammatory infiltration in the livers of rats with bile duct ligation. Conclusion The present study demonstrates that oral administration of thymoquinone in bile duct ligated rats maintains antioxidant defenses and reduces liver oxidative damage of body, which may be useful in pretecting liver function of cholestasis.
  
  
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  药物研究

  Blood Serum Concentration Monitoring for Oxcarbazepine Metabolites in 217 Children with Epilepsy

  LIN Zhi-yan;LIU Hai-tao;SHU Yang;WANG Fang;TIAN Huai-ping;XU A-jing

  2013, 32(1): 12-14. https://doi.org/10.3870/yydb.2013.01.004

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  Objective To analyze the oxcarbazepine metabolite (MHD) blood serum concentration in children with epilepsy. Methods The concentration of active metabolites (MHD) was detected by highperformance liquid chromatography (HPLC) method.The chromatographic column was Inertsil ODS3 (4.6 mm×250 mm, 5 μm), mobile phase was methanol: water (45:55), flow rate was at 1 mL.min^-1, and detection wavelength was at 225 nm. Results Among the data of blood serum concentration detection for MHD of 217 cases, 65.0% of them were within the therapeutic window, 35.0% showed lower blood serum concentrations. Conclusion The individual variation in blood serum concentrations of MHD in children with epilepsy administered with oxcarbazepine is high, therefore monitoring the blood serum concentration is helpful to adjust the dose of medication and to promote the implementation of the individualized dosing regimens.
  
  
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  药物研究

  Isolation and Identification of Flavonoids from Flos Chrysanthemi Indici

  ZHANG Jin-jie;CHEN Yu-feng;YAN Ming;ZHAO Qing-chun

  2013, 32(1): 15-18. https://doi.org/10.3870/yydb.2013.01.005

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  Objective To investigate the chemical constituents in the EtOAc fraction of ethanol extracts from Flos Chrysanthemi Indici. Methods The compounds were isolated by silica gel chromatography,ODS chromatography,Sephadex LH-20 chromatography,and preparative HPLC,and their structures were elucidated on the basis of chemical and spectroscopic Methods . Results Ten flavonoids were isolated from Flos Chrysanthemi Indici,and were identified as tricin(1), 5, 7, 3’, 4’-tetrahydroxy-6, 5’-dimethexyflavone(2), quercetin(3), luteolin(4), qucertin-7-O-β-D-glucopyranoside(5),acacetin-7-O-β-D-glucopyranoside(6),diosmetin-7-O-β-D-glucopyranoside(7), luteolin-7-O-β-D-glucopyranoside(8), apigenin-7-O-β-D-glucopyranoside(9), and linarin(10). Conclusion Qucertin-7-O-β-D-glucopyranoside is isolated from Flos Chrysanthemi Indici for the first time.
  
  
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  药物研究

  Isolation and Identification of Flavonoids from Flos Chrysanthemi Indici

  ZHANG Jin-jie;CHEN Yu-feng;YAN Ming;ZHAO Qing-chun

  2013, 32(1): 15-18. https://doi.org/10.3870/yydb.2013.01.005

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  Objective To investigate the chemical constituents in the EtOAc fraction of ethanol extracts from Flos Chrysanthemi Indici. Methods The compounds were isolated by silica gel chromatography,ODS chromatography,Sephadex LH-20 chromatography,and preparative HPLC,and their structures were elucidated on the basis of chemical and spectroscopic Methods . Results Ten flavonoids were isolated from Flos Chrysanthemi Indici,and were identified as tricin(1), 5, 7, 3’, 4’-tetrahydroxy-6, 5’-dimethexyflavone(2), quercetin(3), luteolin(4), qucertin-7-O-β-D-glucopyranoside(5),acacetin-7-O-β-D-glucopyranoside(6),diosmetin-7-O-β-D-glucopyranoside(7), luteolin-7-O-β-D-glucopyranoside(8), apigenin-7-O-β-D-glucopyranoside(9), and linarin(10). Conclusion Qucertin-7-O-β-D-glucopyranoside is isolated from Flos Chrysanthemi Indici for the first time.
  
  
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  药物研究

  Isolation and Identification of Flavonoids from Flos Chrysanthemi Indici

  ZHANG Jin-jie;CHEN Yu-feng;YAN Ming;ZHAO Qing-chun

  2013, 32(1): 15-18. https://doi.org/10.3870/yydb.2013.01.005

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  Objective To investigate the chemical constituents in the EtOAc fraction of ethanol extracts from Flos Chrysanthemi Indici. Methods The compounds were isolated by silica gel chromatography,ODS chromatography,Sephadex LH-20 chromatography,and preparative HPLC,and their structures were elucidated on the basis of chemical and spectroscopic Methods . Results Ten flavonoids were isolated from Flos Chrysanthemi Indici,and were identified as tricin(1), 5, 7, 3’, 4’-tetrahydroxy-6, 5’-dimethexyflavone(2), quercetin(3), luteolin(4), qucertin-7-O-β-D-glucopyranoside(5),acacetin-7-O-β-D-glucopyranoside(6),diosmetin-7-O-β-D-glucopyranoside(7), luteolin-7-O-β-D-glucopyranoside(8), apigenin-7-O-β-D-glucopyranoside(9), and linarin(10). Conclusion Qucertin-7-O-β-D-glucopyranoside is isolated from Flos Chrysanthemi Indici for the first time.
  
  
抗感染药物专栏
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  抗感染药物专栏

  Antibacterial Activity of Shuanghuanglian Oral Liquid Combining with Gentamicin in vitro

  XU Hai-ying;WANG Shu-fang;WANG Li;WANG Hui

  2013, 32(1): 19-22. https://doi.org/10.3870/yydb.2013.01.007

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  Objective To explore the antibacterial effect of shuanghuanglian oral liquid combining with gentamicin in vitro against staphylococcus aureus and Pseudomonas aeruginosa . Methods The MIC of shuanghuanglian oral liquid or gentamicin against Staphylococcus aureus or Pseudomonas aeru ginosa was detected by a microamount dilution method.The antibacterial activity of shuanghuanglian oral liquid combining with gentamicin was determined by a chessboard dilution method and was assessed according to FIC index． Results These MIC values of shuanghuanglian oral liquid against Staphylococcus aureus and Pseudomonas aeruginosa were 46.88 mg.mL^-1 and 375 mg.mL^-1,respectively, those of gentamicin against Staphylococcus aureusps and pseudomonas aeruginosa were 0.25 U.mL-1 and 1 U.mL^-1, respectively.The FIC indexes of shuanghuanglian oral liquid combining with gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa were all 0.56. Conclusion The antibacterial effect of shuanghuanglian oral liquid combining with gentamicin against Staphylococcus aureus or Pseudomonas aeruginosa is added via an antimicrobial susceptibilities test.
  
  
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  抗感染药物专栏

  Analysis of Drug Resistance of Fungi in Zhejiang Provincial People’s Hospital from 2009 to 2011

  ZHENG Xiao-chun;FANG Qing-xia;LV Liang-zhong

  2013, 32(1): 23-25. https://doi.org/10.3870/yydb.2013.01.008

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  Objective To investigate the drug resistance of fungi isolated from our hospital, so as to provide evidence for reasonable use of antibiotics. Methods The sensitive tests of fungi of clinical isolated strain were taken by ATB-F3 method. Results Among 4 398 fungi, the top three were Candida albicans(75.81%), Candida tropicalis (19.42%), Torulopsis glabrata(1.55%); the nonCandida albicans isolated was in upward trend every year.All the five antibiotics had high susceptibility to Candida albicans.However, the resistance to fluconzole and itraconazole of Candida albicans increased year by year.For Candida tropicalis and Torulopsis glabrata, the three pyrroles antibiotics showed high drug resistance(7.4%-65.2%).Nevertheless, the resistance to Amphotericin B and 5-fluorocytosine was low(0%-7%). Conclusion The pyrroles antibiotics should be used with caution for the nonCandida albicans infection.Amphotericin B and 5fluorocytosine show high sensitivity to the three main Candida.
  
  
药物与临床
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  药物与临床

  Effects of LevonorgestrelReleasing Intrauterine System on Menstrual Patterns of Patients with Adenomyosis

  DUAN Zhi-zhen;HONG Li;CHENG Yan-xiang

  2013, 32(1): 34-36. https://doi.org/10.3870/yydb.2013.01.012

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  Objective To explore the variation of menstrual patterns of patients who suffered from adenomyosis after the treatment with levonorgestrel via intrauterine releasing system. Methods Seventy patients with adenomyosis who were inserted with levonorgestrelreleasing intrauterine system were selected.The variation of menstrual patterns was assessed through menstrual blood loss method and dysmenorrhea scoring at beginning and 1, 3, 6, 9 months after insertion. Results Sixtyfive patients completed followup, which accounted for 92.9%.Menstrual blood volume of baseline and 1,3,6,9 months after therapy was (193.03±134.79), (21.08±32.13), (5.56±7.16), (2.13±4.28), (1.51±2.89), respectively.Compared to the baseline, the menstrual blood volume and blood clot of the patients were significantly decreased at 1,3,6,9 months after treatment.The dysmenorrhea score of 27 patients at the same time point was 1.85±0.82 (priorinsertion), 0.48±0.51 (one month postinsertion), 0.13±0.34 (three months postinsertion), 0 (six months postinsertion), respectively, and the dysmenorrheal normally occurred after vaginal ring operation was obviously relieved after insertion. Conclusion Levonorgestrelreleasing intrauterine system displays good therapeutic effect on improving the menstrual patterns of patients with adenomyosis.
  
  
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  药物与临床

  Comparation of Sufentanil and Fentanyl for Patient-controlled Intravenous Analgesia After Gynaecologic Surgery

  DUAN Guang-you;FAN Long-chang;WANG Juan;FANG Gang;LIU Wei;ZHANG Xian-wei

  2013, 32(1): 36-39. https://doi.org/10.3870/yydb.2013.01.013

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  Objective To compare the efficacy and sideeffects of sufentanil with fentanyl at equivalent dose for postoperative patientcontrolled intravenous analgesia (PCIA) after gynecologic surgery. Methods The total of 400 patients undergoing gynecologic surgery were recruited in this randomized double blind study to receive either intravenous sufentanil at 0.5 μg.mL^-1 (group SF) or fentanyl at 5μg.mL^-1 (group F) for PCIA.Pain intensity according to visual analogue score (VAS), PCA opioid consumption as well as pressing frequency, sedative scores and sideeffects from 0 to 4 h, 4 to 12 h, 12 to 24 h after administration were recorded. Results Both the VAS scores at rest and motion were fewer in group SF than in group F from 0 to 4 h, 4 to 12 h after surgery (P<0.05).The PCIA pressing frequency within 24 h after surgery was lower in group SF than those in group F (P<0.05).The incidences of respiratory depression as well as nausea and vomiting in group SF were lower than those of group S (P<0.05).The degree of variation of PCIA opioid consumption in group SF was lower than group S. Conclusion With a lower incidence of sideeffects, PCIA with sufentanil can provide better postoperative analgesic efficacy than fentanyl after gynecologic surgery.And the interindividual variant degree of sufentanil consumption is lower than that of fentanyl.
  
  
药物制剂与药品质量控制
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  药物制剂与药品质量控制

  Optimization of Process for Total Flavonoids Purification from Tengligen with Macroporous Adsorption Resin

  TENG Kun;RUAN Hong-sheng;WU Zi-jing;ZHAO Rui;ZHAO Zh-qing

  2013, 32(1): 63-65. https://doi.org/10.3870/yydb.2013.01.022

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  Objective To study the purification process for total flavonoids from Tengligen with macroporous adsorption resin. Methods Dynamic adsorptiondesorption was adopted to screen the optimal type of resin by measuring the adsorption ratio, eluting ratio of total flavonoids.The purification procedure was confirmed via determination of optimal loading volume and velocity, watereluting amount, eluting rate, desorption concentration and volume of ethanol. Results The AB-8 macroporous adsorption resin presented the best separating efficiency, the rate of adsorption was 84.76%, the rate of desorption was 95.51%, loading 30 mL extracts, flowing at 3 BV.h^-1, with eluting agent as 8 BV purity water eluting at 4 BV.h^-1, and 4 BV 70% ethanol, and eluting at 3 BV.h^-1. Conclusion Total flavonoids from Tengligen can be well adsorbed and separated under the optimized conditions with AB-8 macroporous absorbent resin.
  
  
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  药物制剂与药品质量控制

  Optimization of Water Extraction Process for Preparing Xiefei Pingchuan Ling Granules with Multi-index

  DING Xiao-jing;CHAO Jian-guo;HAN Xin-ming;SHAN Jin-jun

  2013, 32(1): 66-68. https://doi.org/10.3870/yydb.2013.01.023

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  Objective To optimize the extract process for preparing xiefei pingchuan ling granules. Methods The three extracting factors as water volume, extracting time, and frequency on the extracting process were studied by comphrehensively evaluating the yield of ephedrine hydrochloride, total anthraquinone, and extractum with orthogonal test of L9(34) method. Results The optimum extracting technologies for preparing xiefei pingchuan ling granules were that by using ten times of water, extracting three times, one hour for each time. Conclusion The optimized process is feasible and stable, which provides experimental evidences for the industrial production.
  
  
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  药物制剂与药品质量控制

  Fingerprints Comparation of Pule’an Manufactured from Different Enterprises by HPLC

  ZHANG Wen-ting;SHENG Yan;CHENG Xia-qian

  2013, 32(1): 69-71. https://doi.org/10.3870/yydb.2013.01.024

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  Objective To establish a chromatographic fingerprint analysis for the quality control of Pule’an preparations. Methods HPLC method was applied to detect 27 batches of Pule’an preparations.The HPLC system consisting a C18 column (250 mm ×416 mm ,5 μm ) and a mixture of acetonitrile (A) and 0.4 % phosphoric acid (B) with gradient elution as the mobile phase was adopted.The column temperature was set at 30 ℃ and flow rate was at 1.0 mL.min^{- 1}.The monitoring wavelength was set at 270 nm and 360 nm. Results Twenty common characteristic peaks were determined for Pule’an preparation.The similarity among 27 batches of Pule’an, including ten kinds of tablets and two kinds of capsules from different manufacturing enterprises was 0.976-1.000. Conclusion The HPLC fingerprint established is repeatable, feasible for analyzing Pule’an and which can be used to evaluate the quality of Pule’an.
  
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  药物制剂与药品质量控制

  HPLC Fingerprint of Kalimeris Indica(L.) Sch-Bip

  CHEN Hua-guo;JIANG Rong-bin;GONG Xiao-jian;TIAN Li;ZHOU Xin;YANG Shi-lin;

  2013, 32(1): 71-76. https://doi.org/10.3870/yydb.2013.01.025

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  Objective To establish a HPLC fingerprint analysis for Kalimeris indica(L.) Sch-Bip. Methods The HPLC method was used with Diamonsil C₁₈ column, and a mixture liquid of acetonitrile -0.5% formic acid as mobile phase in a gradient elution.The HPLC fingerprint for 10 batches of Kalimeris indica(L.) Sch-Bip was studied on their similarity and cluster. Results The fingerprint detection for Kalimeris indica(L.) Sch-Bip was established and herbs from different areas presented different fingerprints. Conclusion This method is reasonable and reliable for the quality control of Kalimeris indica(L.) Sch-Bip.
  
  
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  药物制剂与药品质量控制

  Determination of Related Substances of Compound Piperaquine Phosphate Tablets by HPLC

  XIONG Miao-miao;WANG Qiu-lan;SHI Chun-yang;FANG Jian-guo;XIE Wei;Wan Jin

  2013, 32(1): 75-77. https://doi.org/10.3870/yydb.2013.01.026

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  Objective To establish a HPLC method for determination of related substances of compound piperaquine phosphate tablets. Methods The column was Waters Atlantis C18(250 mm×4.6 mm, 5 μm).The mobile phase was 10 mmol.L^-1 sodium 1-heptanesulfonate and 25 mmol.L^-1 potassium dihydrogen phosphate equal mixture acetonitrilemethanol(53:16:31, adjusted to pH 2.5 with phosphoric acid).The flow rate was set at 0.9 mL.min^-1 .The detective wavelength was at 348 nm and the column temperature was at 40 ℃. Results The two main chromatogram peaks were successfully seperated from other impurity ones; the limit of detection for piperaquine phosphate was 0.41 ng, while for sulfadoxine was 108.24 ng. Conclusion This method is simple, rapid, accurate and reliable, which is suitable for determination of the related substances of compound piperaquine phosphate tablets.
  
  
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  药物制剂与药品质量控制

  Preparation and Quality Control of Compound Ornidazole Effervescent Suppository

  GAO Xin-fu;ZHAO Yong-de;JIANG Hong;XING Shu-li;XU Yan-fei

  2013, 32(1): 78-80. https://doi.org/10.3870/yydb.2013.01.027

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  Objective To prepare the compound ornidazole effervescent suppository and establish a method for its quality control. Methods Ornidazole was compatible with miconazole nitrate to form the effervescent suppository, the content of which were determined with high performance liquid chromatography (HPLC), the stability was tested. Results The preparation was stable.The method for content determination was accurate with a good linear range at the concentration of 40-200 μg.mL^-1 for both ornidazole and miconazole nitrate.Their average recovery was 100.09% (RSD=0.15%), 100.02% (RSD=0.35%), respectively. Conclusion The prescription and preparation technology of compound ornidazole effervescent suppository is rational and the quality shows stable and controllable.
  
  
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  药物制剂与药品质量控制

  Determination of Five Saponins From Sanqi Capsule by Ultra Fast Liquid Chromatography

  TAN Chun-mei;FANG Cui-feng;CHEN Bi-lian

  2013, 32(1): 81-84. https://doi.org/10.3870/yydb.2013.01.028

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  Objective To establish an ultra fast liquid chromatography (UFLC) method for determining five saponins in sanqi capsule. Methods Chromatography was performed on an shimadzu C18 column (75 mm×2.0 mm, 2.2 μm) at 25 ℃.The gradient elution was acetonitrile-water at a flow rate of 0.3 mL.min^-1.The detection wavelength was at 203 nm. Results The linear ranges for notoginsenoside R1, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1 and ginsenoside Rd were 9.38-351.62 ng (R²=1), 52.11-1 954.12 ng (R²=0.999 9), 6.85-152.17 ng (R²=0.999 6), 44.99-1 687.25 ng (R²=1), 9.96-221.27 ng (R²=1), respectively.The average recoveries were 96.6% for notoginsenoside R1 (RSD=0.9%), 97.1% for ginsenoside Rg1 (RSD=1.4%), 101.0% for ginsenoside Re (RSD=1.4%), 97.9% for ginsenoside Rb1 (RSD=2.4%), 98.2% for ginsenoside Rd (RSD=1.8%), respectively (n=6). Conclusion The method is simple, rapid and suitable for determination of five saponins in sanqi capsule.
  
  
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  药物制剂与药品质量控制

  Content Determination of Linarin in Qiweiqingquan Granules by HPLC

  GONG Xue-peng;DU Guang

  2013, 32(1): 84-86. https://doi.org/10.3870/yydb.2013.01.029

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  Objective To establish a method for the content determination of linarin in qiweiqingquan granules. Methods HPLC was performed on DIONEX C18(250 mm×4.6 mm,5 μm )with column temperature at 25 ℃ and methanol-water-glacial acetic acid(52:46:2) as mobile phase .The detection wavelength was at 334 nm and the flow rate was at 0.8 mL.min^-1. Results The linear range of linarin was within 0.068-0.340 μg.The average recovery rate was 99.56%,RSD=2.12%(n=5). Conclusion The method is simple, specific and repeatable for the quality control of qiweiqingquan granules.
  
用药指南
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  用药指南

  Systematic Evaluation of Efficacy and Safety of Compound Salvia Droplet Pills for Angina Pectoris

  YE Tai-sheng;ZHANG Ying-wen;HU Han-kun

  2013, 32(1): 100-105. https://doi.org/10.3870/yydb.2013.01.036

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  Objective To evaluate the efficacy and safety of Compound Salvia Droplet Pills (CSDP) for treating angina pectoris. Methods Foreign database (Cochrane Library online edition) and Chinese database (Chinese Biomedical Database, China Academic Journal Fulltext Database of Chinese Scientific Journals, and Wanfang Digital Journal Fulltext Database) were retrieved via internet, according to Cochrane systematic review method of quality evaluation.Metaanalysis of homogeneous studies was carried out with RevMan 5.0, and descriptive qualitative analysis was performed for the data could not be merged. Results The Results showed that CSDP alleviated the onset of angina pectoris(OR=2.18, 95% CI [1.75,2.70],P<0.000 01), improved ischemic ECG(OR=2.39,95%CI [1.99,2.88],P<0.000 01), lowered cholesterol(WMD=1.31, 95% CI [1.03, 1.58],P<0.000 01) and triacylglycerol(WMD=2.05, 95%CI [1.65,2.45],P<0.000 01), and raised the heart rate variability, and presented no obvious side effects. Conclusion CSDP demonstrated curative effect on angina pectoris, and no obvious side effects, which suggest that CSDP are effective and safe for treating angina pectoris.
  KEY WORDS Salvia Droplet Pills, compound; Angina pectoris; Efficacy; Safety; Systematic evaluation