药物研究
ZENG Chunhui;YANG Ke;DENG Jiagang;YANG Bin;XU Mingguang;LI Xianmei
ABSTRACTObjectiveTo investigate longterm toxicity of daganqing granules in rats. MethodsThe total of 60 Wistar rats were randomly divided into the high,middle and low dose groups,which were treated with daganqing granules (170.0,85.0 and 42.5 g 8226;kg-18226;d-1 crude drug) by intragastric administration,respectively,once a day for 90 days. The general behaviors and physical status,hematology,blood biochemistry,organs coefficient and histopathological analysis were detected in 90 days and 14 days after drug withdrawn. ResultsNo significant difference in body weight was found between treated rats and the blank control despite the rats treated with 170.0 g8226;kg-1. There were focal moderate fatty infiltration developed in eight rats and diffuse moderate fatty infiltration in one rat by histopathological examination. However,these symptoms subsided in 14 days after medication termination. The serum creatinine was significantly reduced after consecutive 90 days’therapy of daganqing granules compared with that in the control group (P<0.05),while which were reversed to normal in 14 days after supplements termination. There were no significant differences observed between two other treating groups and the control in the general behaviors and physical status,the hematology,blood biochemistry,organs coefficient and histopathological status. ConclusionDaganqing granules are safe by intragastric administration at the dosage in clinical range.