ABSTRACTObjectiveTo study the antiinflammatory effect of tripterygium glycosides. Methods①The capillary permeability in mice：a total of 60 mice were randomly divided into the blank control，model control，tripterygium glycosides at 0.3，0.6，1.2 g8226;kg－1 doses，10 mg8226;kg－1 indomethacin groups. Mice were orally administrated for 5 days，later they were intravenously injected with 0.5% evans blue dye solution 0.01 mL8226;g－1.By the end of experiment，mice were sacrificed and peritoneal lavage fluid was collected for determination of absorbance(A value); ②The carrageenin paw swelling in rats：fifty rats were randomly distributed into blank control，tripterygium glycosides at dose of 0.25，0.50，1.00 g8226;kg－1，4 mg8226;kg－1 dexamethasone groups. after the model was established，rats were continuously given intragastric administration for 7 days，and the volume of right hind limb was determined. ResultsThe a value of peritoneal lavage fluid in the blank control，model control，tripterygium glycosides at dose of 0.25，0.50，1.00 g8226;kg－1 and 4 mg8226;kg－1 dexamethasone was 0.24±0.16，1.41±0.60，0.99±0.45，0.93±0.45，0.88±0.58，0.52±0.38，respectively，which demonstrated that tripterygium glycosides inhibited capillary permeability of mice.The foot swelling rate in the groups of blank control，tripterygium glycosides at dose of 0.25，0.50，1.00 g8226;kg－1 and 4 mg8226;kg－1 dexamethasone was （36.3±13.7）%，（26.3±13.9）%，（37.9±14.5）%，（32.5±12.4）%，（17.2±10.9）%，respectively 5 h after last administration. ConclusionTripterygium glycosides has certain antiinflammatory and swelling reducing effects.