2012, 31(11): 1404-1407.
ObjectiveTo investigate the effects of Renshujianwei granula on matrix metalloproteinase 2 (MMP2) in rats with spleenqi deficiency syndrome chronic atrophy gastritis (CAG).MethodsSpleenqi deficiency syndrome of the CAG model was established, except for the normal control. The model rats were randomly divided into the model control group (0.9% sodium chloride solution), the weifuchun group(0.86 g8226;kg－1), the highdose (12 g8226;kg－1), middledose (6 g8226;kg－1) and lowdose (3 g8226;kg－1) of Renshujianwei granula groups. Rats were i.g. treated for consecutive five weeks. All of the rats were sacrificed by the tenth weekend. The quality of spleen weighed, the gastric mucosa tissue was macroscopically observed and the expression of MMP2 was detected by rapid immunohistochemistry. ResultsGastric mucosa was deep claybank in the model group, in which the expression of MMP2 was higher than that of the normal (P＜0.01). In comparison to the model group, MMP2 were significantly decreased in the highdose, middledose and lowdose of Renshujianwei granula groups as（2.20±1.30）,（1.20±0.45）,（2.60±1.95）(P＜0.01 or P＜0.05) , respectively, and the gastric mucosa of which presented as a small amount light yellow, some yellowish, and large number yellow, respectively. ConclusionThe therapeutic effect of Renshujianwei granula for CAG is associated with a reduction of MMP2 expression in gastric mucosa.