ABSTRACTObjectiveTo investigate the effects of single use of rosuvastatin （RS） or plus with aspirin （ASA） on serum inflammatory factors and carotid intimamedia thickness （IMT） in patients with carotid atherosclerosis （CAS）. MethodsSixty healthy people with the normal carotid artery were randomly selected as a control group，while 214 CAS patients were randomly divided into ASA group （n=72，po. aspirin entericcoated tablets 100 mg8226;d1），RS group （n=71,oral RS 10 mg8226;d1） and RA group （n=71，oral RS10 mg8226;d1 plus aspirin 100 mg8226;d1） for 6 months. All people must take low fat food during observation period. Carotid IMT，plaque number，serum lipids，highsensitivity Cresponsive protein（hsCRP） and matrix metalloproteinase9（MMP9） were detected before treatment and after 6 months. Results①Compared with those before treatment，hsCRP and MMP9 were lower （P＜0.05） ；HDLC was obviously increased （P＜0.05） and TC，TG，LDLC，hsCRP，MMP9，carotid IMT and plaque number were significantly decreased（P＜0.05 or P＜0.01） in RS and RA group. ②After treatment，HDLC was higher（P＜0.05 ） and TC,TG,LDLC,hsCRP,MMP9,carotid IMT and plaque number were lower（P＜0.05 or P＜0.01） in RS and RA group than those in ASA group；HsCRP,MMP9 and carotid IMT were lower in RA group than those in RS group （P＜0.05）. ConclusionRS and ASA have an antiatherosclerosis effect，and RS is superior to ASA；Combination therapy of RS plus ASA could exert significantly synergistic effect，and the mechanisms of which may be associated with lipidlowering，plateletblocking，and inflammatory inhibition.