Objective To investigate recent researches on adverse drug reaction (ADR) in literatures,and a comprehensive review of previous studies,find problems inside and explore a better research methodologies. Methods Statistical analysis of online journals for adverse drug reactions reported in China between 2004 to 2009 was carried out,and various multidimensional comparation was studied. Results Current researches on adverse drug reactions are only concerned with the frequency of occurrence; from the frequency,the chemical drugs derived adverse reactions have been more reported,most of which are the antimicrobial drugs,drugs on central nervous system,on circulatory system,antineoplastic agents.The side effects of which are involved in the various organs,and some are serious. Conclusion The rational use of medicines should be enforced and provide more adequate and practical reference for clinical medication,in order to reduce and prevent the occurrence of ADR.