中国科技论文统计源期刊 中文核心期刊
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
In patients with pulmonary fungal infection, the concentration of the drug in the lung tissue infection/colonization site more accurately reflects the clinical efficacy after the use of triazole antifungal drugs.This paper summarized the research progress about triazole antifungal drug concentration in lung tissue of patients with pulmonary fungal infection after administration, and summarized the determination of drug concentration in alveolar epithelial lining fluid and the permeation characteristics of different drugs.
The incidence of asthma is higher in pregnancy, and poorly controlled asthma during pregnancy can seriously affect maternal and fetal outcomes.The effective management and reasonable treatment of asthma during pregnancy is critical.We reviewed the latest high quality test researches about asthma during pregnancy, and we overviewed the effects of cardiovascular and respiratory physiology changes on asthma.At the same time, we systematically expounded the comprehensive treatment, management and the treatment of asthma related complications.It was hoped to provide professional guidance for medication in patients with asthma during pregnancy.
Objective Through establishing accurate, reliable analytical method of evaluation and uncertainty analysis, to develop the certified reference materials (CRMs) of baicalein in Scutellaria Baicalensis and its alcohol extract, water extract which have measurement traceability and value transfer function. Methods On the basis of Technical Norm of Primary Reference Material and related documents requirements, using the quantity transmission of the national level CRM of baicalein, the homogeneity and the stability were checked by high performance liquid chromatography (HPLC), the content standard value and uncertainty of CRMs of baicalein in scutellaria baicalensis and its 95% alcohol extract, water extract were determined by HPLC in collaboration with a number of laboratories. Results The series of CRMs showed satisfactory homogeneity and stability.The content values of baicalein were (7.95±0.23)%, (4.29±0.12)%, (8.80±0.40)% (k=2), respectively. Conclusion The series of CRMs are assigned as national measurement of CRMs, which possess a high-accuracy value and traceability characteristics.The series of CRMs could provide the accurate and reliable CRM, materials standard and standard methods for standardization and internationalization of active ingredient of traditional Chinese medicines and extracts.
Objective To investigate the efficacy and skin irritation of transdermal formulations of lappaconitine liposome gel. Methods Analgesic effect of lappaconitine liposome gel and lappaconitine gel was investigated by mouse hot plate test and mouse writhing test.Adjuvant arthritis rat model was established to compare the anti-inflammatory effect of the two kinds of transdermal gel by measuring the degree of rat foot swelling, rat serum tumor necrosis factor (TNF-α) and interleukin-2 (IL-2), and observing pathological section of rat ankle joints as observation indexes.Skin irritability of lappaconitine liposome gel was observed by rabbit intact and damaged skin test. Results Compared with the lappaconitine gel group, pain threshold increased and sensitivity to heat decreased with time increase of administration in the lappaconitine liposome gel group, and the difference was statistically significant at 4 h (P<0.01).Frequency of writhing decreased in the lappaconitine liposome gel group at 15 min; the rat’s foot circumference decreased, the expression of TNF-α and IL-2 decreased (P<0.05), and the inflammatory reaction decreased; the lappaconitine liposome gel had nonirritant to the skin. Conclusion Lappaconitine liposome gel has better analgesic and anti-inflammatory effects than lappaconitine gel, and it is not irritant to intact or damaged skin.
Objective To investigate the effect of lipoxin A4 on aged rats with isoflurane-induced neuroinflammation and cognitive dysfunction in aged rats. Methods One hundred and twenty male SD rats, were randomly assigned into 4 groups (n=30): control group (group C), 1.4% isoflurane group (group I), 0.3 nmol·L-1 Lipoxin A4+1.4% isoflurane group (group L+I) and 0.3 nmol·L-1 Lipoxin A4 group (group L).Lipoxin A4 was administered by intracerebroventricular injection before the start of anesthesia in group L+I and group L, respectively.Group I and group L+I was exposed to 1.4% isoflurane for 6 h, while group C and group L exposed to 30%O2-70%N2.At the end of anesthesia, 25 rats in each group were randomized to do arterial blood gas test and expression of TNF-α, IL-6, IL-1β and IκBα (0, 3, 6, 12 and 24 h after anesthesia) was detected.The other rats in each group were sent back to their home cage until they were fully awake.Fourteen days after anesthesia, Morris water maze was used to assess the cognitive function; and then hippocampus of rats was dissected for detection of the expression of IκBα. Results As compared with group C, IL-6 and IL-1β were significantly increased 0, 3 and 6 h after anesthesia, TNF-α was significantly increased 0, 3, 6 and 12 h after anesthesia, IκBα was significantly decreased 0, 3 and 6 h after anesthesia in group I (P<0.05).As compared with group I, TNF-α, IL-1β and IL-6 were significantly decreased and IκBα significantly increased 0, 3 and 6 h after anesthesia in group L+I (P<0.05).On the 3rd and 4th day of Morris water maze test, rats in the group L+I spent less time locating the platform than those in group I, and the percentage of time spent in the target quadrant was more in the group L+I than in group I (P<0.05). Conclusion Lipoxin A4 can attenuate cognitive dysfunction induced by isoflurane in aged rats.The mechanism is associated with inhibition of hippocampal proinflammatory cytokines which is increased by isoflurane.
Objective To investigate the effects of butein on the proliferation, tyrosinase (TYR) activity, melanin synthesis and the mRNA expression of tyrosine-related protein 1 (TRP-1) and tyrosine-related protein 2(TRP-2) in the in vitro co-culture model of keratinocytes and melanoma cells. Methods The in vitro co-culture model of A375 and Hacat cells was established.Melanosome synthesis changes induced by different concentration of butein in mixed cultures of A375 and Hacat cells were observed 48 h after treatment, respectively.The cell proliferation rate was detected by MTT, the melanin content was measured with a sodium hydroxide solubilization method, the activity of TYR was estimated by measuring the rate of oxidation of L-dopa, and the mRNA expression of TRP-1 and TRP-2 were determined by real-time PCR. Results Compared with negative control group, after the treatment with butein (1.0 μg·mL-1 and 5.0 μg·mL-1) for 48 h, the cell proliferation rate of co-culture system of A375 and Hacat cells were significantly increased (P<0.05 or P<0.01), the content of melanin and TYR activity was increased (P<0.05 or P<0.01), the mRNA expression of TRP-1 and TRP-2 was increased (P<0.01). Conclusion The butein up-regulates TYR activity, as well as the mRNA expression of TRP-1 and TRP-2, and then promotes melanosome synthesis in co-culture system of A375 and Hacat cells.
Objective To evaluate the effects of dexmedetomidine on oxidative stress response and apoptosis during lung ischemia-reperfusion (IR) in rats. Methods Forty-eight adult male Sprague-Dawley rats were randomly divided into 3 groups (n=16 each) using a random number table: sham operation group (group S), group IR, and dexmedetomidine pretreatment+IR group(group D).Dex medetomidine was injected at 25 μg·kg-1 20 min before ischemia in Dex group.The equal volume of 0.9% sodium chloride soution was injected into group S and group IR, respectively.Rats were euthanized 2 h after reperfusion.The left lung tissue was extracted.Wet lung weight and dry lung weight (W/D) and total lung water content (TLW) were tested.Morphology of lung tissue was observed.The left lung tissues were removed for determination of malondialdehyde (MDA) content (by thiobarbituric acid method) and superoxide dismutase (SOD) activity (using xan-thine oxidase method).The bcl-2, bax and Caspase-3 protein expression was detected by Western blotting. Results Compared with group S, W/D and TLW of the lung tissue in the other two groups were all significantly increased (P<0.01).Compared with group IR, W/D and TLW of the lung tissues in group D were all significantly reduced (P<0.01).As compared with group S, MDA was increased and SOD decreased, bax and Caspase-3 protein expression increased, bcl-2 protein expression decreased in the lung tissue of the other two groups (P<0.01).As compared with group IR, MDA decreased and SOD increased more significantly in group D (P<0.01), bax and Caspase-3 protein expression decreased and bcl-2 increased more significantly (P<0.01). Conclusion Dexmedetomidine can alleviate lung IR injury in rats, and the mechanism is related to inhibition of oxidative stress response and apoptosis.
Objective To observe the long-term toxicity of Chailian Ganmao granules on rats to provide a scientific experimental basis for clinical treatment. Methods Totally, 120 SD rats were randomly divided into high, middle, low dose Chailian Ganmao granules groups and solvent control group.They were intragastrically administered with Chailian Ganmao Granules at 45.0, 24.0 and 12.0 g·kg-1 (in crude drugs), and 20 mL·kg-1·d-1 pure water, respectively daily for 31 d. The general condition of rats and body weight, the hematology index, blood biochemistry index, viscera coefficient and histopathological changes during administration and 14 d after drug withdrawal were observed. Results In comparison with the solvent control group, the growth of body mass was reduced in the high dose group, food consumption only in the 7th and 14th day decreased, the coefficient of thymus gland reduced, the coefficient of liver and adrenal gland increased, cholesterol decreased, and gradually recovered after drug withdrawal.The body weight, food intake, hematology index, blood biochemical parameters, organ coefficient and pathological examination indexes of rats were not changed significantly. Conclusion Under the experimental conditions, the non-toxic reaction dose of Chailian Ganmao granules is considered to be 24.0 g·kg-1 (28 times as much as the clinical dosage) for 31 d in rats.
The irrational use of drugs in China is still serious. Moreover, the abuse of antibiotics is a prominent problem, and the usage of antibiotics is far exceeding the standard established by WHO, which is no more than 40 DDD (daily drug dose, DDD) per 100 people per day. Respiratory infection is one of the common clinical diseases and one of major complications. The use of antibiotics is essential for respiratory diseases. In order to promote the safe, effective and economical use of antibiotics and to avoid bacterial resistance, it is very important to standardize the anti-infective treatment for respiratory infections and systemic infections. This article summarizes the selection strategies and experience of the "six appropriate" use of antibiotics in respiratory infections for reference.
Objective To investigate the influence of pharmacist-led intervention on the mastery of inhalation techniques for patients with asthma/COPD. Methods The inhalation technique assessment form was used to assess the patient mastery of inhalation technique.The patient mastery of inhalation technique after the pharmacist’s face to face intervention was compared to find the effect of pharmacist intervention on inhalation techniques. Results With pharmacist intervention, the frequency of patient making mistakes in using different devices was significantly decreased.The frequency of making mistakes in using Symbicort Turbuhaler and HandiHaler for each patient decreased from 3.22 to 0.65, and from 3.20 to 0.56, respectively. Conclusion The patients with asthma and COPD poorly mastered inhalation technique.Pharmacists intervention has definite effect on the correct use of inhalation device.It is necessary for pharmacists to evaluate the mastery of inhalation technique for patients with asthma/COPD.
Inhalation therapy is the first-line treatment of chronic obstructive pulmonary disease.Medication management of inhalation therapy is closely related to medication treatment.Based on 2017 GOLD guideline, this article introduces how to develop medication management of inhalation therapy from three aspects: effectiveness assessment, safety assessment and medication compliance management, so as to facilitate medication therapy.
Objective To observe the effects of two regimens on patients with agitation after craniocerebral trauma in intensive care unit (ICU). Methods Fifty patients with craniocerebral trauma were randomly divided into midazolam combined with sufentanil group (group M) and propofol combined with sufentanil group (group P).When agitation appeared in the patient for the first time, in group M: midazolam was intravenously infused at a loading dose of 0.05 mg·kg-1·h-1, followed by intravenous pumping at 0.05-0.1 mg·kg-1·h-1, and sufentanil was intravenously infused at a loading dose of 0.15 μg·kg-1·h-1, followed by intravenous pumping with 0.1-0.15 μg·kg-1·h-1; Group P: propofol was intravenously infused at a loading dose of 0.5-1.0 mg·kg-1·h-1 in 30 s, and maintained at 1.0-2.0 mg·kg-1·h-1; the usage of sufentanil was the same as that of group M.The criteria for discontinuation of medication were as follows: medication continued after the peak of cerebral edema in the patient, the non-verbal adult pain score (NVPS) was 0 to 2 points, and the sedation-agitation score (SAS) was 3 to 4 points.NVPS scores, SAS scores, mean arterial pressure, heart rate, respiratory rate, percutaneous oxygen saturation, and adverse reactions were observed at 10 min, 1 h, 6 h, and 12 h after treatment. Results After treatment, the analgesic scores of both groups were significantly decreased (P<0.05).The analgesic score decreased more significantly in group P than in group M at 12 h (P<0.01).At 6 and 12 h, the sedation scores of both groups were significantly decreased (P<0.05), and those the group P decreased more significantly (P<0.01).After treatment, the mean arterial pressure, heart rate and respiratory rate of both groups were significantly decreased (P<0.05), and the percutaneous oxygen saturation increased compared with that before administration (P<0.05).After treatment, the mean arterial pressure of group M was not significantly different from that of group P.The heart rate and respiratory rate of group P were significantly lower than those of group M at 6 and 12 h (P<0.01), and the percutaneous oxygen saturation of group P was lower than that of group M at 1 and 6 h (P<0.05).There was one case of respiratory depression in group P and one case of delirium in group M, and both of the symptoms improved after treatment. Conclusion The combination of sufentanil and propofol regimen has a better analgesic and sedative effect in ICU patients with agitation after craniocerebral trauma, and has fewer adverse reactions and is safe in the therapeutic dose.
Crisaborole is a novel, nonsteroidal, topical anti-inflammatory ointment, and inhibits overactive PDE4 to reduce the local inflammation.Studies showed that inflammatory cells from patients with atopic dermatitis (AD) had subnormal cAMP levels due to increased PDE4 activity, and increased production of inflammatory cytokines.A literature search was conducted using Medline with the key word Crisaborole.Its pharmacological effects, pharmacodynamics, pharmacokinetics, clinical assessment of the treatment of atopic dermatitis, dosage, safety and drug interactions were reviewed in this paper.
Objective To prepare gemcitabine hydrochloride thermosensitive hydrogel for interventional embolization of hepatocellular carcinoma. Methods The viscosity, complex modulus and gelation temperature of gemcitabine hydrochloride thermosensitive hydrogel were determined by rotating rheometer.An HPLC method was established to determine the contents of gemcitabine and iohexol.The in vitro release of gemcitabine from thermosensitive gel was investigated by peristaltic pump. Results The average viscosity was (31.06±1.72) mPa·s-1,and complex component was (120.20±9.15) Pa, the average gelation temperature was (34.30±0.01) ℃.Good linearity was obtained for gemcitabine within the range of 5-200 μg·mL-1 with an average recovery of 100.53%, RSD was 0.95% (n=9).Good linearity was obtained for iohexol within the range of 34-1372 μg·mL-1, with an average recovery of 99.83%, and RSD of intra-day was 0.77% (n=9).The cumulative release rate of gemcitabine hydrochloride 12 h in phosphate buffer solution (pH=6.8) was up to 90.98% in vitro,and the release model was fitted to the Ritger-Peppas equation. Conclusion Gemcitabine hydrochloride thermosensitive gel can be used as an interventional embolization agent for liver cancer because of its controllable quality.
Objective To establish a method to analyze As-species and Cr(VI) in Chenxiang Huaqi pill by IC-ICP-MS. Methods 0.15 mol·L-1 nitrate solution was applied as extractant at 80 ℃ in oven to extract six different As-species, which were AsB, DMA, As, AsC, (III) MMA, As (V).K2HPO4-KH2PO4 buffered solution, MgCl2·6H2O and alkaline extract was applied to extract Cr(VI) from Chenxiang Huaqi pill.The content was determined by IC-ICP-MS. Results The result showed that the main species of arsenic in Cuscuta was As (III) and As (V).The Cr(VI) level was extremely low.The recovery rate of As-species ranged from 92.4% to 105.8%, and recovery rate of Cr(VI) was 101.29%. Conclusion The method is sensitive, accurate and effective to separate and analyze As-species and Cr(VI) in Chenxiang Huaqi pill.
Objective To prepare ketotifen fumarate sustained-release capsules and evaluate its release rate in vitro. Methods Extrusion spheronization technique was introduced to prepare ketotifen fumarate pellets.The pellets were coated in the fluidized bed and then filled in the vacant gelatin capsules.Effect of different coating material proportion, porogen on release rate was evaluated by single factor. Dissolution curve of the coated pellets was compared with that of the commercial pellets with similar factor method. Results Surelease was used as the sustained-release layer material with coating weight increment of 8%, porogen of 3%.Comparison of average release rate in vitro between 3 batches of the coated pellets and 3 batches of commercial pellets showed the similarity factor f2 was more than 50, and the RSD between batch and batch was better than that of sustained-release tablets. Conclusion The prepare method suitable to prepare ketotifen fumarate sustained-release capsules, the coating pellets has good effect of sustained-release in vitro.
Objective To establish a UPLC-MS/MS method for simultaneous determination of nine main active components in Eucommia wine. Methods The determination was performed on a Waters HSS T3 column (50 mm× 2.1 mm, 1.8 μm) with gradient elution (mobile phase A: 0.1% formic acid in Milli-Q water and mobile phase B: 0.1% formic acid Acetonitrile).The column temperature was maintained at 40 ℃.The flow rate was 0.4 mL·min-1. The analytes was quantitatively on a Waters UPLC-MS/MS system with multiple reaction-monitoring (MRM) acquisition modes. Results The calibration curves of these analytes showed good linearity (r>0.9990) within the test ranges of 7.68-492 ng·mL-1 for Rosin glycoside, 6.75-432 ng·mL-1 for Peach leaf coral glycosides, 8.13-520 ng·mL-1 for ligustrin, 7.62-488 ng·mL-1 for Genipin, 6.44-412 ng·mL-1 for Geniposide, 8.69-556 ng·mL-1 for Geniposidic acid, 6.06-388 ng·mL-1 for Caffeic acid, 7.88-504 ng·mL-1 for Chlorogenic acid, 7.81-500 ng·mL-1 for Protocatechuic acid, respectively.And the RSD of recovery test was less than 4.81% (n=9). Conclusion The method is rapid, sensitive, and accurate, and can be applied in the quality control of Eucommia wine.
Objective To establish quality analysis of Zhitu liuweisan. Methods Zhitu liuweisan was identified by microscopic identification method.The moisture, ash, and extract of Zhitu liuweisan were determined based on the methods of Chinese pharmacopoeia (2015 edition).The thin layer chromatography was adopted to identify Radix Glycyrrhizae, Fructus Coriandri, Fructus Foeniculi, Pyrus ussuriensis Maxin.of Zhitu liuweisan.Liquiritin and glycyrrhizic acid in Zhitu liuweisan were determined by high performance liquid chromatography.The determination was performed on Syncronis C18 (250 mm×4.6 mm, 5 μm) with mobile phase consisting of acetonitrile-0.05% phosphoric acid at flow rate of 1 mL·min-1.The detection wave length was set at 263 nm and the column temperature was 38 ℃. Results Except Fructus Coriandri, the other herbs in Zhitu liuweisan had significant microscopic characteristics.The content of moisture was 6.89%-7.75%; the content of total ash was 4.06%-4.40%; the acid insoluble ash was 1.24%-1.44%; water extract was 21.17%-22.63%.TLC spots of Fructus Coriandri, Fructus Foeniculi, Radix Glycyrrhizae, Pyrus ussuriensis Maxin.were clear and well-separated without interference from negative control.Good linearity was obtained for liquiritin and glycyrrhizic acid within the range of 0.06-3.00 μg and 0.078 4-0.392 0 μg, respectively. The average recovery were 99.06%~101.90%,99.66%~100.83% respectively. Conclusion The methods were reliable, accurate and can be used for quality control of Zhitu liuweisan .
Objective To establish a microbial limits test method for artificial Bovis Calculus. Methods Study on applicability of microbial limits test method for artificial Bovis Calculus according to the instructions in Chinese Pharmacopoeia 2015 Edition general rules 1105, 1106 and 1107 to validate the applicability of microbial limits test methods for artificial Bovis Calculus through examining the recovery rate of the microbial strains. Results Plating method by adding neutralizing agent could be used for counting bacteria, fungi and yeast.Routine method could be used for testing the control bacteria, such as Escherichia coli, bile-tolerant gram-negative bacteria and Salmonella paratyphi B. Conclusion The microbial limits test methods for artificial Bovis Calculus have been established successfully.
Objective To develop a rapid ultra high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for determination of rivaroxaban in human plasma. Methods Sample treatment procedure was based on the use of the protein precipitation technique with acetonitrile.D4-rivaroxaban was selected as internal standard.The chromatographic separation was performed with a Thermo Hypersil Gold C18 analytical column (2.1 mm×100 mm, 1.9 μm) and a gradient mobile phase \[acetonitrile and water containing 0.1% formic acid and 5 mmol·L -1 ammonium acetate\].API 4000+ triple-quadrapole MS/MS detection coupled with UPLC LC-30AD was operated in a positive mode by multiple reaction monitoring.Ion transitions at m/z 436.1→m/z 145.1 for rivaroxaban and m/z 440.2→m/z 145.0 for d4-rivaroxaban (internal standard) were used for the UPLC-MS/MS analysis, respectively. Results Good linearity was obtained for rivaroxaban within the range of 1-500 ng·mL-1 in human plasma.The lower limits of quantification of current method was 1 ng·mL-1 for rivaroxaban.The intra- and inter-day precision was <8%.The absolute recoveries ranged from 90.09% to 95.23% and the matrix effects were 93.50%~100.09%.The sample concentration was not changed significantly under the following condition: 20 ℃ for 4 h, at 4 ℃ for 24 h, at -80 ℃ for 50 days, freezing and thawing 3 circles. Conclusion Precision, accuracy, recovery, matrix effect and stability for rivaroxaban are excellent within a wide calibration range.The established method is easy and rapid.It could be applied to the quantification of rivaroxaban in human plasma and contribute to clinical drug-drug interaction study as well as individualized medication.
Objective To measure the prevalence and risk factors of potentially inappropriate medication (PIM) use among elderly inpatients by using the Chinese PIM list and 2015 Beers criteria. Methods The data of patients ≥65 years of age and hospitalized in Department of Internal Medicine in the Third People’s Hospital of Hefei from January to June in 2017 were collected and the gender, age, department, diseases that patients suffered from, hospitalization days, drug varieties used in one patient, methods of payment were recorded.The situation of PIM was analyzed according to the Chinese PIM list (Chinese list, including 72 drugs) and 2015 Beers criteria (PIM associated with age, including 62 drugs) and the risk factors of PIM use were analyzed by logistic regression. Results A total of 431 patients were enrolled, including 236 males and 195 females.Of the 431 patients, 284(65.9%)patients were 65-<80 years old and 147(34.1%)were ≥80 years old.According to the Chinese list and 2015 Beers criteria, 52.7%(227/431)and 24.6%(106/431) of patients were prescribed one PIM drug(χ2=63.120, P=0.000).The results of Logistic regression showed that the main risk factors of PIM use were ages[OR=0.700,95%CI(1.292,3.139),P=0.002] and varieties of prescribed drugs [OR=1.295,95%CI(2.561,5.208),P=0.000] by using the Chinese list, and number of diseases that patients suffered from[OR=0.334,95%CI(0.989,1.972),P=0.048] and varieties of prescribed drugs [OR=0.865,95%CI(1.663,3.392),P=0.000] by using 2015 Beers criteria. Conclusion According to the Chinese PIM list, the prevalence of PIM use in elderly inpatients in our hospital is higher.The risk factors of PIM use are patients’ age, number of diseases that patient suffered from and varieties of drugs according to the Chinese PIM list and 2015 Beers criteria.
Objective To analyze the results of medical order review and effects of interventions for irrational use of intravenous medications in Pharmacy Intravenous Admixture Services (PIVAS), so as to provide evidence for medical order review and interventions for irrational use of intravenous medications. Methods Data on the results of medical order review and effects of interventions for irrational use of intravenous medications from January to December 2017 were searched in the hospital information system (HIS); statistical analysis was performed using Excel 2007.Results From January to December 2017, a total of 130 688 medical orders regarding intravenous medications were reviewed, among which 982 involved interventions for irrational drug use, and the irrational drug use accounted for 0.75%; successful intervention was obtained in 525 of the 982 medical orders for irrational drug use, and the intervention success rate was 53.46%.Among the irrational medications, inappropriate dose was the most frequent (36.96%), and it was associated with the lowest intervention success rate (33.06%); inappropriate solvent selection accounted for 9.67% of the irrationals, and it was associated with the highest intervention success rate (92.63%), followed by that for inappropriate solvent amount (80.00%).The proportion of medical orders regarding irrational drug use varied significantly among different departments, and the intervention success rate for irrational drug use was higher in surgical departments than in medical departments. Conclusion In order to improve the success rate of interventions for irrational drug use, it is vital to regularly summarize and analyze the irrationals in drug use, and to consolidate the review criteria in an effort to harmonize the prescription review practice of different pharmacists.For the departments initially introducing PIVAS, prioritized interventions for irrational use of key medications is expected to effectively reduce irrational drug use.
Objective To establish a new pharmaceutical care mode, a kind of PIVAS prescription review mode based on “Pharmacist + Intelligent Software” to promote medication safety. Methods According to the current problems, the pharmacist standardizing training plan was implemented to improve efficiency of prescription reviewing.The normalized prescription review mode was carried out by optimizing PIVAS software, the professional teams were structured to carry out clinical pharmacy services and conduct clinical investigation. Results A new and applicable pharmaceutical care mode based on PIVAS prescription review has been established. Conclusion The new pharmaceutical care mode offered a way for pharmacist to show our professional value, and played an important role in ensuring the safety of clinical intravenous drugs and accelerating the transformation of clinical practice mode from "doctor-nurse-technologist" to "doctor-pharmacist- nurse-technologist".
