中国科技论文统计源期刊 中文核心期刊
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
Objective To study the molecular mechanism of Huanglian (Coptis chinensis Franch) in prevention and treatment of hepatitis B and non-alcoholic fat liver disease based on molecular docking analysis and network pharmacology technology,and to provide a reference for clinical application. Methods Based on Traditional Chinese Medicine Systems Pharmacology (TCMSP) database,effective chemical composition of Huanglian were retrieved.Rat acute toxicity,AMES toxicity and Carcinogens of effective chemical composition were predicted by admet SAR.Retrieval of therapeutic targets of effective chemical composition based on CTD, TCMSP,Drug Bank and Uniprot.The potential targets were analyzed by DAVID and use Rstudio ggplot2 software to establish network model.Docking of effective chemical composition and rheumatoid targets base on sybyl. Results Eight effective chemical composition of Huanglian.Toxicity prediction shows high safety of Huanglian.Collection of 84 potential targets and 83 metabolic pathways.Including access hepatitis B(P-value=3.5E-19) and non-alcoholic fatty liver disease (P-Value=9.9E-8). Moupinamide,palmatine, (R)-canadine and quercetin play an important role in hepatitis B and non-alcoholic fatty liver disease.MAPK1 and MAPK3 were the key target proteins in the treatment of hepatitis B and non-alcoholic fatty liver disease.Moupinamide activity was best associated with the formation of 16 hydrogen bonds and 63 amino acid sites with 7 key target proteins. Conclusion The active ingredients and molecular mechanism of non-alcoholic fatty liver disease and Hepatitis B with Huanglian,it provides a theoretical basis for the clinical application of active ingredients in Huanglian.
Objective To explore the effect and mechanism of osmanthus fragrans seed extract on acute lung injury in rats. Methods Forty-eight SD rats were randomly divided into 6 groups (8 in each group). The rats of high,medium and low dose group were given 400,200,and 100 mg·kg-1 osmanthus fragrans seed extract by gavage, respectively.In the positive control group,rats were given 3 mg·kg-1 prednisone. The rats of blank control group and the model control group were given corresponding doses of 0.9% sodium chloride solution for 10 consecutive days. At 24 h and 12 h before the sampling,the model group,the positive control group and the drug-administered group were given 20% yeast suspension respectively,and the blank group was given the same amount of 0.9% sodium chloride solution. The lung wet/dry ratio and lung tissue edema were observed. The pathological changes of lung were observed by HE staining. The contents of MPO,IL-6,IL-2 and TNF-α in each group were determined. And the expression of NF-κB,p65 and IκBα protein was determined by Western blot. Results Compared with the blank control group,the inflammatory cells in the lungs of the model group were significantly infiltrated,the bronchial wall was thickened,the edema index was significantly increased(W/D、LI value,P<0.01),and the plasma levels of MPO,IL-6,IL-2 and TNF-α were significantly increased (P<0.01). The expression of IκBα protein decreased (P<0.01),and the expression of NF-κB p65 increased (P<0.01). Compared with the model group,the inflammatory cell infiltration of the lungs in the drug-administered group was significantly reduced, the bronchial wall thickening was significantly improved,and the edema index was significantly reduced (LI value in medium and large dose group, P<0.05; W/D value in medium and large dose groups, W/D value in positive dose group, LI value, P<0.01). Osmanthus fragrans extract can significantly reduce the contents of MPO,IL-6,IL-2 and TNF-α in rats with lung injury (low-dose group TNF-α,medium-dose group MPO activity,compared with the model control group,P<0.05;the other drug-treated groups compared with the model control group,P<0.01). With the treatment of the extract, the expression of IκBα protein increased and the expression of NF-κB p65 decreased (P<0.01). Osmanthus fragrans seed extract can significantly reduce the contents of MPO,IL-6, IL-2 and TNF-α in rats with lung injury (P<0.05), raise the expression of IκBα protein and decrease the expression of NF-κB p65 (P<0.01). Conclusion Osmanthus fragrans seed extract has protective effect on acute lung injury in rats,and its mechanism is related to the up-regulation of IκBα and activation of NF-κB p65.
Objective To study the antioxidant activity and inhibitory effect of α-glucosidase of different polar fractions of ethanol extract from Mesona chinensis,and to selected the optimal extract. Methods The ethanol extract of Mesona chinensis was prepared,and then extracted with petroleumether,chloroform,ethyl acetate,and water saturated n-butanol to obtain different polarity parts.Determination the scavenging capacity of 1,1-Diphenyl-2-picrylhydrazyl (DPPH )free radical, 2,2’-azino-bis (3-EthylBenzo-thiazoline-6-sulfonic acid) diammonium salt (ABTS) free radical and ferric ion reducing antioxidant power (FRAP) value,and the half-inhibition rate (IC50 value) was calculated based on the scavenging rate to investigate the antioxidant capacity of different parts.By comparing the inhibitory ability of different sites on α-glucosidase,to investigate different parts of the best inhibition of α-glucosidase.The content of polyphenols in different parts were determined. Results The results showed that every polarity fraction has antioxidant function and the ethyl acetate fraction has the strongest antioxidant capacity.The IC50of DPPH· scavenging rate was 19.13 μg·mL-1,the IC50 of ABTS+ scavenging rate was 18.20 μg·mL-1,and the FRAP value was equivalent to Fe2+392.07 μg·mL-1.Comparison of α-glucosidase inhibitory effects of different fractions,the n-butanol fraction was the best. Conclusion The extract and the different polar fractions have certain antioxidant activity and inhibition of α-glucosidase.This study can provide a theoretical basis for further research and development of Mesona chinensis Benth.
Objective To prepare Wuwei Jinse sustained release tablets and to study the pharmacokinetics of Wuwei Jinse sustained release tablets and commercial pills. Methods Preparation of Wuwei Jinse sustained release tablets by single factor method.Single-dose oral,double cycle cross test,using commercially available pills as a reference preparation,simultaneous determination of plasma concentrations of both components by LC-MS/MS method,and pharmacokinetic parameters were fitted with das 2.0. Results The preparation of Wuwei Jinse sustained release tablets showed good reproducibility and stable performance.The concentration of ellagic acid and dehydrocostus lactone in plasma was measured with paeoniflorin as the internal standard.The linear relationship was observed in the range of 1.006-301.8 ng·mL-1.The average recovery rate was greater than 85.81%.The intra-day and inter-day precision were determined. RSD are all less than 9.74%.The tmax of Wuwei Jinse sustained-release Tablets dehydrocostus lactone and ellagic acid in plasma was significantly higher than that of the sustained-release pellets,and there was no significant difference in Cmax,AUC,and MRT.Wuwei Jinse sustained release tablets and sustained release pills are the same as dehydroabiolide and ellagic acid,longer peak time,slow release of active ingredients,and delay of toxicity. Conclusion The method can be used to study the pharmacokinetics of Wuwei Jinse sustained release tablets.The self-made sustained-release tablets have sustained-release effect.
Objective To establish the evaluation index to system of animal skin infection abscess model,to screen the high-quality model of skin abscess in mice infected with Staphylococcus aureus,and to verify the model by evaluating the efficacy of Pouzolzia zeylanica. Methods On the basis of literature research and expert consultation,to the comprehensive evaluation index system of skin infection abscess model was established by the analytic hierarchy process.The mice were randomly divided into four groups, including the control group and the high, medium and low concentration groups of staphylococcus aureus.All groups were observed and recorded for 19 days, then the models were comprehensively evaluated.The best model was selected and applied to evaluate the anti-skin infection efficacy of Pouzolzia zeylanica. Results The evaluation index system of animal skin infection abscess model was relatively comprehensive, and the index weight enhanced the objectivity of evaluation.The abscess model in mice which established by subcutaneous injection with 0.1 mL staphylococcus aureus solution (1×1013 cfu·L-1)had high success rate and good stability,and it had the highest overall score.Abscess and inflammation and bacterial infection significantly decreased with the increasing dose of Pouzolzia zeylanica ointment . Conclusion The evaluation index system of animal skin infection abscess model is successfully constructed.The optimal skin mice model infected with staphylococcus aureus provides a reliable animal model for study of skin infections and therapeutic drugs.Pouzolzia zeylanica ointment has anti-skin infection effect.
To standard the clinical diagnosis and treatment of severe and critical novel coronavirus pneumonia(COVID-19), improve the treatment and reduce the fatality rate, we develop the diagnosis and treatment plan for severe and critical novel coronavirus pneumonia, including diagnostic criteria, early warning indicators, treatment process and nursing plan, based on the National Health Committee of China published novel coronavirus pneumonia diagnosis and treatment plan(trial version 6)and severe and critical novel coronavirus pneumonia diagnosis and treatment plan(trial version 1) , combined with the practice of early medical treatment experience, to provide the reference for counterparts.
During the period of the novel coronavirus pneumonia outbreak,the state took scientific research as one of the important measures to deal with the epidemic situation. The medical professionals at the anti-infectious disease frontline have registered more than 210 clinical trials involving the treatment and control of the novel coronavirus pneumonia,which have been carried out one after another. The difficulty of clinical trials in patients with the novel coronavirus pneumonia is unprecedented. Therefore,the determination of trial projects must be careful,the number and scope of the project must be moderately grasped,the implementation process must be scientific and appropriate,and the ethical requirements of clinical trials should not be weakened at all. Adopting these effective measures to provide the necessary medical services to protect the best interests of subjects with thenovel coronavirus pneumonia are most important in the clinical trails.
According to Class B epidemic and quarantinable infectious disease, for infection prevention Noval coronavirus(2019-nCoV)pneumonia outbreak, the overriding priority currently to inform community prevention. This paper is based on the laws and regulations of the National Health Commission of the People's Republic of China, scientific research and evidence-based medicine report to compile community prevention guidance, in order to provide suggestion and guidance for preventing further infection outbreak.
Patients with severenovel coronavirus pneumonia(NCP)account for approximately 15% of all confirmed cases of 2019 novel coronavirus disease(COVID-19)infection.Currently,patients with severe NCP are all treated in the intensive care unit(ICU)according to guidelines.Becausethere are currently no specific drugsthat specifically target COVID-19,the mortality of patients with severe NCP is still high.Based on the clinical manifestations of patients with severe NCP in this outbreak,Huashan Hospital affiliated with Fudan University proposed the “Huashan model” for the treatment of patients with severe NCP infected with COVID-19: supportive therapy is the core,combined with the early use of high-dose glucocorticoid to control inflammation, intravenous immunoglobulin(IVIG)therapy to neutralize toxins, and preventive anticoagulant therapy.This paper introduces the four treatments used in the "Huashan model" and their mechanisms, in order to provide treatment options and a reference for the effective treatment of patients with severe NCP infected with COVID-19.
We discussed the novel coronavirus pneumonia(NCP)from the perspective of traditional Chinese medicine(TCM), and put forward the viewpoint of "Shidu Plague".We conducted theoretical discussion and induction on the category of TCM classification, etiology, pathogenesis, syndrome characteristics and clinical classification of NCP.TCM advocates prevention before disease, prevention of disease, can participate in the early treatment of disease, improve the curative effect.
Since December 2019,a new outbreak of novel coronavirus pneumonia in Wuhan has been reported.The new virus has been tentatively named 2019-nCov.The virus has a long incubation period and is highly infectious.The focus of the anti-epidemic work should be more inclined to prevention and control,while treating infected patients to cut off the transmission of the virus, to protect healthy people.Based on the national health committee related prevention and control measures,the latest medical information,reports,clinical treatment experience,epidemic prevention and control research,explores under the new situation,to cope with the new coronavirus of prevention and control work of how to develop a more comprehensive prevention and control measures and methods, a greater extent,to reduce the cross infection and the spread of the epidemic,provide new proposals and ideas for the epidemic prevention and control work.
In December,2019,a series of pneumonia caused by the SARS-CoV-2 emerged in Wuhan.The confirmed and suspected cases are rising nationwide with the SARS-CoV-2 spread.Doctors,nurses,pharmacists and technicians from Union Hospital,Tongji Medical College,Huazhong University of Science and Technology are fighting on the front lines of the epidemic.Among them,therapeutic drug monitoring(TDM)pharmacists handle a large number of blood samples every day.It is very important to protect occupational exposure of personnel and manage the biosafety of laboratory.Therefore,the authors summarized the experience of infection prevention and control of TDM pharmacists under pneumonia outbreaks in their hospital,hoping to provide reference and help for the prevention and control of the infection for colleagues.
COVID-19 has a certain degree of similarity with the pathogen genes of SARS and MERS.In this paper,we collected information and compared the clinical and epidemiological characteristics of COVID-19,SARS,and MERS.We found that the three infectious diseases had many similarities in clinical symptoms.However,they were varied in the process of disease progression,disease severity,and chest X-ray and CT findings.From the epidemiological point of view,COVID-19 is significantly more infectious than SARS and MERS,and the number of confirmed cases has far exceeded the other two infectious diseases.However,its case fatality rate is lower than that of SARS and MERS.This article also summarizes the experiences of prevention and control of SARS,and provides a reference for the effective control of the current COVID-19 epidemic.
Since the outbreak of Corona Virus Disease 2019, the department of pharmacy of Sichuan Provincial People’s Hospital has formulated the rational use and pharmaceutical care of antiviral drugs such as lopinavir/ritonavir and α-interferon with the diagnosis and treatment schemefor Corona Virus Disease 2019 released by the National Health Commission as reference to guide the rational use of drugs in clinic.This paper summarizes the above work in order to provide reference for the diagnosis and treatment of Corona Virus Disease 2019and rational use of drugs in other medical institutions.
Objective To study the characteristics of psychological factors and sleep status of medical personnel infected with new type of novel coronavirus pneumonia(NCP),and to provide basis for the comprehensive treatment of their psychosomatic diseases. Methods Seventy patients with NCP and the control group were assessed the mental state with symptom Checklist-90(SCL-90),Patient Health Questionnaire(PHQ-15),Self-rating Anxiety / Depression Scale(SAS / SDS),and Post-Traumatic Stress Disorder self-assessment scale(PTSD Checklist-Civilian Version,PCL-C).And Pittsburgh Sleep Quality Index(PSQI)was applied to assess their sleep status.The correlation between psychological factors and sleep factors was analyzed. Results The results of SCL-90 factor scores in infection group showed that the factor scores in somatization,depression,anxiety,and phobia were higher than those in control group.The factor scores of somatization,depression,and phobia,total points and total average score showed significant differences between the NCP group and control group(P<0.05).The factor scores of PHQ-15,SDS,and PCL-C of NCP patients were higher than the normal range.The factor scores of SDS and PCL-C have statistical difference between NCP group and control group(P<0.05).The factor scores of PHQ-15 have statistical difference between NCP group and control group(P<0.05).Among 70 patients in the NCP group,15 patients had mild insomnia with a total PSQI factor scores of 7-11,accounting for 21.43%;49 patients had moderate insomnia with a total PSQI score of 12-16,accounting for 70%; and 6 patients had severe insomnia with a total PSQI score of 17-21,accounting for 8.57%.The total average score of PSQI was 14.60±2.06,of which sleep quality(2.40±0.97)was the highest.There were statistical differences between the NCP group and the control group in PSQI testing dimensions except for the factor of hypnotic drugs(P<0.05).There were significant differences in sleep time and sleep efficiency between the two groups(P<0.05).The total score of PSQI was 14.00,indicating that the sleep quality was general.In the correlation analysis,the scores of somatization,total score,depression,and phobiain SCL-90,PHQ-15,SDS,and PCL-C were significantly correlated with other dimensions of PSQI except for hypnotics,sleep time and sleep efficiency(P<0.05). Conclusion The medical staff infected with NCP had mental disorder,stress disorder,and sleep disorder,which were mutually affected.
Moringa oleifera is a perennial tropical deciduous plant, which is originated from India, Kenya and Nigeria.According to foreign literature and national medication experience, the leaves, seeds, flowers and roots are used in medicine.These parts have different functions and exhibit diverse biological activities, which are caused by their chemical constituents.This paper reviews the chemical constituents and pharmacological activities of different medicinal parts of Moringa to make references of further research and development.
Phlorizin is a major active component of Lithocarpus polystachyus Rehd,which is a kind of Chinese folkloric medicine. Accumulating evidence demonstrate that phlorizin exhibits multiple pharmacological effects including anti-oxidative effect,hypoglycemic effect, anti-inflammation, anti-tumor effect and anti-ischemia stroke.Based on domestic and foreign research reports,the pharmacological effects and its underlying molecular mechanisms of phlorizin were reviewed in this article.It will provide clue and evidence for research and development of phlorizin.
Objective To optimize the prescription and forming process of Qingyi granules and determine the content of anthraquinones. Methods With the formability,solubility,water content and angle of repose as the indexs,the ratio of the extract powder to the filler,the ethanol concentration,the concentration and amount of the binder PEG6000,the size of granulation sieve and the drying temperature were taken as the investigation factors,the formulation and molding process of Qingyi granules were optimized by Plackett-Burman (PB) design.The content of the anthraquinones were determined by HPLC. Results The best prescription and process were as follows:dextrin: powder extract=0.5:1,preparation of 1% PEG6000 with 95% ethanol as solvent, and the dosage of 25%,granulation sieve of 16 mesh,and drying temperature of 65 °C.According to this process,the forming rate,solubility,water content,angle of repose and moisture absorption rate of Qingyi granules were (94.83±0.47)%,(75.15±0.44)%,(5.96±0.15)%,(22.55°±0.22°) and (12.78±0.33)%,respectively.Aloeemodin,rhein,emodin and chrysophanol showed a good linear relationship in the range of 2.5-40.0 μg·mL-1,A good linearity of physcion was in the range of 2.0-32.0 μg·mL-1. Conclusion The molding process was reasonable,feasible and stable.The established HPLC method which was accurate,simple and reproducible,can be used for the quality control of Qingyi granules.
Objective To establish a quantitative analysis of multi-components by single-marker(QAMS) method for simultaneous determination of nine components(harpagide,harpagoside,catalpol,verbascoside,jionoside B1,oxypaeoniflorin,albiflorin,paeoniflorin and benzoylpaeoniflorin) in Baihe Gujin Tablet. Methods A Diamonsil C18column(250 mm×4.6 mm,5 μm) was used.The mobile phase was acetonitrile(A)-0.2% phosphate acid solution(B) at the flow rate of 0.9 mL·min-1 for gradient elution.The determination wavelengths were 210 nm for harpagide,harpagoside and catalpol,330 nm for verbascoside and jionoside B1,230 nm for oxypaeoniflorin,albiflorin,paeoniflorin and benzoylpaeoniflorin.The column temperature was 25 ℃.Paeoniflorin was used as the internal reference substance.The relative correction factors (RCF) between the paeoniflorin and harpagide,harpagoside,catalpol,verbascoside,jionoside B1,oxypaeoniflorin,albiflorin,benzoylpaeoniflorin were established to detect the quantitation of paeoniflorin and calculate the quantitation of the other eight constituents.The external standard method was used for quantitating the nine constituents,and the method was evaluated by comparing to the quantitative results between external standard method and QAMS method. Results The results obtained by QAMS approximated those obtained by external standard method. Conclusion The use of relative correction factor is feasible to assay the content of nine components in Baihe Gujin Tablet,The QAMS method can be used for the quality assessment of Baihe Gujin Tablet.
Objective To establish the quality standard of Yujujiangsuan tea. Methods The Yujujiangsuan tea was prepared according to the prescription and preparation process.The quality standards of Yujujiangsuan tea was established according to Chinese pharmacopoeia (2015 edition).Then, the properties, water content,loading difference,and microbial limit were checked .We thin layer chromatography (TLC) was used to identify the leaves of mulberry and bamboo.High performance liquid chromatography (HPLC) was used to analyze the main components of gallic acid and puerarin. Results All the inspection items met the standards.The characteristic spots on TLC were clear.In the HPLC chromatogram, the resolution of gallic acid,puerarin and other components was good.The result of gallic acid showed good linearity in the range of 45.58 to 911.6 μg·mL-1.And the average recovery was 100.47% (RSD 4.16%).The linearity range of puerarin was 15.69 to 313.8 μg·mL-1, and the average recovery of 95.41% (RSD 3.70%). Conclusion The preparation technology of yujujiangsuan tea is simple and the quality standard can be used to control its quality.
Objective UPLC method was established to analyze the content changes of the main components of green fructus forsythiae to evaluate the quality difference of green fructus forsythiae in different regions. Methods The contents of phillyrin,forsythiaside A and rutin in 18 regions were determined by UPLC.The importance degree was judged by AHP method.The weight of each component was calculated.According to the weight calculation,the comprehensive score of each sample was used to evaluate the comprehensive quality of green fructus forsythiae. Results The comprehensive scores of 5 batches of green fructus forsythiae samples in Yuyang District,Shiyan City averaged 89.4,which was generally higher than other regions. Conclusion Shiyan City, Hubei Province,is a traditional production area of wild medicinal materials of green fructus forsythiae,as long as the standard harvest time and processing technology of the region can ensure the quality and uniformity of the quality of green fructus forsythiae in this region,high lighting the genuineness of the wild green fructus forsythiae in the region.
Objective To established a method of high performance liquid chromatography with refractive index detector for the determination of glycerol in glycerol suppositories. Methods Calcium cation (Ca2+) exchange column (Rezex RCM-Monosaccharide Ca2+(8%),300 mm×7.8 mm) with sulfonated crosslinked styrene-divinylbenzene copolymer was used as the filler.The mobile phase consisted of 0.1 % calcium chloride dihydrate.The flow rate was 0.6 mL·min-1 and the column temperature was 60 ℃.The refractive index detector was set at 55 ℃. Results The linear range of glycerol was 0.03-2.8 mg·mL-1 (r= 0.999 0).The average recoveries (n=9) of glycerol was 99.4%. Conclusion The method is accurate,simple and rapid,which can be used for the determination of glycerol in glycerol suppositories.
Objective To study the quality standard of Qiangjinqushiye in order to control the quality of the preparation. Methods TLC was used to identify Fangji,Rhizoma Corydalis,Dioscorea multiflorum,Radix Polygoni multiflorum,Lilac and Achyranthes bidentata.The content of Tetrandrine was determined by HPLC. Results In TLC identification assay, the negative control sample was well separated from impurity spots.There was a good linear relationship the concentration of Tetrandrine and the peak area in the range of 0.073 8-0.246 0 μg·mL-1 (r=0.999 7). Conclusion The method established in this paper is simple, reproducible and specific,and it can be used for the quality control of Qiangjinqushiye.
Objective To systematically review the efficacy and safety of hydrocortisone combined with fludrocortisone in treatment of septic shock in adults. Methods Cochrane Library,EMbase,PubMed,CNKI,CBM,VIP and Wanfang data were searched for the controlled trials on hydrocortisone combined with fludrocortisone in the treatment of septic shock in adults from inception to May 2019. Two researchers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed using RevMan 5.3 software. Results A total of 6 studies involving 2 374 patients were included, of which 1 194 patients in the experimental group and 1 180 patients in the control group. In terms of efficacy,combined hydrocortisone with fludrocortisone could reduce 28-day mortality rate [RR=0.87,95%CI(0.77,0.98),P=0.02], ICU mortality rate [RR=0.87,95%CI(0.78,0.97),P=0.01] and in-hospital mortality rate [RR=0.89,95%CI(0.81,0.97),P=0.01] with significant difference compared to the control group. In terms of safety,combined hydrocortisone with fludrocortisone couldn’t increase gastroduodenal bleeding [RR=0.98, 95%CI(0.68,1.41),P=0.90] and superinfection [RR=1.09, 95%CI(0.93,1.27), P=0.28] with no significant statistical significance. Conclusion The current evidence shows,hydrocortisone combined with fludrocortisone can reduce 28-day mortality,ICU mortality and in-hospital mortality in the treatment of septic shock in adults. However, it doesn’t increase the risk of gastroduodenal bleeding and superinfection. Due to limited quantity and quality of the included studies, more large scale and high quality studies are needed to verify the above conclusions.
Objective To evaluate the effectiveness and safety of deferasirox versus deferoxamine in the treatment of thalassemia major patients. Methods Systematically searched online databases up to December 2017, the online databases including Pubmed, Embase,Cochrane library, CNKI, Wanfang, China biomedical literature database and VIP database. Randomized controlled trails on deferasirox versus deferoxamine for thalassemia major treatment were included in the study. The original research data were analyzed by RevMan 5.3. Results Through literature retrieval and screening,a total of 10 articles were included in this study,there were 2 Chinese and 8 English literature. The quality of the included studies in this article was not high. In observation period, the changes of serum ferritin [MD=296.61,95%CI(-13.64,606.86),P=0.06] and liver iron concentrate [SMD=0.25,95%CI(-0.41,0.91),P=0.46] were not statistically significant between deferasirox and deferoxamine group. There were no statistical significance in adverse reactions [RR=0.48,95%CI(0.09,2.63),P=0.4] and mortality [RR=0.96,95%CI(0.85,1.08),P=0.52] between two group. Conclusion Deferasirox is as effective and safety as deferoxamine for the treatment of thalassemia major iron overload in the short term. The long-term efficacy and safety of deferasirox need to be to evaluated by more randomized controlled trails.
Objective To analysis of the legal definition of counterfeit drugs in Pharmaceutical Administration Law of the People's Republic of China, and to provide suggestions for law enforcement practice. Methods Comparing and studying the provisions on counterfeit drugs in Pharmaceutical Administration Law of the People's Republic of China before and after the revision, we put forward some law enforcement suggestions based on practical cases. Results In the revised Pharmaceutical Administration Law of the People's Republic of China, it defines counterfeit drugs more accurately, and more severe penalties for counterfeit drugs were taken into account the actual situation of law enforcement. Conclusion In the practice of law enforcement, we should pay more attention to the actual harm caused by relevant behaviors, should be careful to define behavior as the manufacture and sale of counterfeit drugs, more flexible legal means should be adopted, the defendant should be allowed to abstract the counterevidence of dangerous crime.
Objective To introduce the management of generic drugs payment price of health insurance system in the Taiwan region and to provide references for decision making about managing the generic drugs payment price of health insurance system in Chinese mainland. Methods The classification of generic drugs and the determination and adjustment of payment price of generic drugs in the Taiwan region were systematically analyzed,and the characteristics of generic drug price management was summarized to put forward suggestions for Chinese mainland based on the condition of its management of generic drugs payment price of health insurance system. Results In the Taiwan region,generic drugs are divided into two types,the ones that have went through BA/BE studies and the others. The characteristics of generic drug price management include pricing according to quality classification,reference pricing based on the condition of home and abroad,and dynamic classified price adjustment. The generic quality and consistency equivalency(GQCE) is classified to be carried out in batches in the Chinese mainland,and the policy of differential payment of generic drugs has not been made clear. Conclusion It is suggested to set different payment criteria, payment criteria adjustment mechanism. At the same time, combining with the experience of the Taiwan region, it is suggested to control drug cost to set different ways of adjustment and portion about payment depending on the life cycle of generic drugs.
Objective To provide reference for pharmaceutical manufacturers to effectively carry out bidding work under the mode of volume-based purchasing. Methods The “4+7 Drug Centralized Procurement Documents” issued by the National Joint Procurement Office on November 15, 2018, to understand the purchasing model with quantity and the bidding price of pharmaceutical manufacturers, and use the game theory and the probability density function to minimize the bidding. The price method is a bid evaluation method to construct the optimal bidding decision game model for drug manufacturers in the case of information asymmetry. Results The optimal bid price for pharmaceutical manufacturers is related to the estimated maximum cost m and minimum cost n of competitive pharmaceutical manufacturers. The larger the number of pharmaceutical production enterprises, the closer the bid price is to the cost, and the optimal bid price is the cost c plus $\frac{1}{2k-1}$ that the pharmaceutical manufacturer considers the difference between the highest cost m and the cost c. In the case of information asymmetry, the more drug manufacturers that have more information on competitors, the more first-mover advantage, and the greater the probability of winning the bid. Through further simulation examples, the theoretical results obtained are analyzed and verified. Conclusion Under the background of the continuous deepening reform of the pharmaceutical market, pharmaceutical manufacturers should win the bid in the centralized procurement process by reducing costs and proposing the most competitive bidding quotations. However, in a competitively motivated market environment, pharmaceutical manufacturers cannot focus solely on lowering drug prices, but more importantly on the quality of drug-preserving drugs, effectively occupying market share and achieving long-term sustainable development goals.
