中国科技论文统计源期刊 中文核心期刊
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
Increasing attention has been paid to the accessibility of pediatric drugs due to the lack of suitable drugs for children in China.Clinically,the pediatric fluid management,especially the rational selection of crystalloids,was urgently needed for professional guidance and specification.Therefore,based on domestic and foreign literatures,the recommendations and additions of children-friendly crystalloid specifications had been compiled and given by experts from medicine,hospital pharmacy,pharmaceutical preparation and pharmaceutical management,who were gathered and organized by Beijing Institute of Medicine and Health Economics.
Objective To investigate the effect and mechanism of chrysin on atherosclerosis (AS) induced by high-fat diet in rabbits. Methods Twenty-four male rabbits were randomly divided into three groups: normal control group, model control group, and chrysin group, with 8 rabbits in each group.Rabbits in the model control group and chrysin group were given high fat diet to establish atherosclerosis model.Rabbits in chrysin group were given 25 mg·kg-1 of chrysin, and rabbits in normal control group and model control group were given equal volume of 0.5% of sodium carboxyl methyl cellulose. After 8 weeks of administration, serum lipid levels, aortic pathological changes, aortic superoxide anion (O2·-) levels, and oxidative stress status were observed. Results Compared with model control group, the serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels in chrysin group were significantly reduced (P<0.05), and high-density lipoprotein cholesterol (HDL-C) level was increased (P<0.05), and the pathological changes of aorta were alleviated, and the aortic O2·- level (P<0.05) and MDA level were significantly decreased (P<0.05), and SOD activity was significantly increased (P<0.05). Conclusion Chrysin has a significant intervention effect on AS induced by high-fat diet in rabbits.Regulation of the blood lipids and inhibition of aortic oxidative stress may be one of the anti-AS mechanisms of chrysin.
Objective To investigate the effect of stem cell leukemia (SCL) gene therapy on the expression of c-kit protein on the surface of Cajal like stromal cells (ICCs) in the injured bladder of guinea pigs with diabetic bladder disease (DCP). Methods Sixty healthy guinea pigs were administrated with 1% streptozotocin (200 mg·kg-1) in a single intraperitoneal injection to construct diabetic bladder disease model.Twenty-seven guinea pigs with diabetic bladder disease were randomly divided into three groups according to the random number table method: experimental group, positive control group and blank control group, with 9 guinea pigs in each group.SCL gene recombinant lentivirus solution (0.2 mL) with a titer of 2×107 U was injected through the urethra in the experimental group.The positive control group was perfused with 0.2 mL of empty lentivirus carrying SCL gene through the urethra, and the blank control group was perfused with 0.2 mL phosphate buffer (PBS).Three guinea pigs were selected from each group, and the bladder was taken after anesthesia on the 7th, 14th, and 28th day after perfusion.ICCs cells in guinea pig DCP bladder were extracted by enzyme digestion.The morphology of ICCs was observed under an inverted microscope.Green fluorescent antibody was used.The green fluorescent labeled ICCs were detected by laser confocal microscopy and the fluorescence intensity of ICCs was determined.Western blot was used to detect the expression of c-kit protein on the surface of ICCs. Results The recombinant lentivirus was successfully transfected into guinea pig DCP bladder, and the transfection effect was the best at 14 days.The fluorescence intensity and c-kit protein expression of ICCs in the experimental group were significantly enhanced compared with the other two groups (P<0.05).No significant difference in fluorescence intensity and c-kit protein expression between the positive control group and the blank control group was found (P>0.05). Conclusion Transfection of SCL gene into DCP bladder can enhance the expression of c-kit protein on the surface of ICCs in high glucose environment, which may be beneficial to the recovery of ICCs function in DCP bladder.
Objective To examine hotspots and trend in frontier researches on high-risk drugs management and compare the current status of high-risk drugs management at domestic and international,which provides reference for the establishment of universally applicable high-risk drugs management regulations and practical management systems in line with China's medical system. Methods Through the data base of Web of science and CNKI,we searched relevant literatures published during 1999—2019 via the advanced search function.After excluding duplications,we conducted analyses on journal-specific number of citations,frequency of key words,and weight of mutated key words for the 1336. Results Foreign studies of high-risk drugs management focus more on the safety of elderly drug use and the quality management.Domestically,it is mainly concentrated on management practice research such as high-risk drugs management methods and effect evaluation in medical institutions.Drug safety and risk management are the common research hotspots in the field of high-risk drugs management at domestic and international. Conclusion The management of high-risk drugs in oversea pay more attention to drug safety for elderly and risk control factors. However,there are mostly qualitative studies on the standardized management of high-risk drugs in China.
Objective This article aims to define the liability subjects of risk control of high-risk drugs and their demands of each responsible subject on the risk management of high-risk drugs, so as to provide a reference for more scientific and effective risk management of high-risk drugs. Methods Through the literature research, the relevant responsible subjects for high-risk drugs management were initially determined.The survey scale was designed according to the Mitchell scoring principle, and the liability subjects of risk control of high-risk drugs was determined through two rounds of expert consultation.According to the scores of experts in the three dimensions of risk control responsibility, risk control participation, and risk handling ability, the responsibility index was calculated and classified. On-site questionnaire clarified the demands of the liability subjects for the risk management of high-risk drugs in China. Results Through expert consultation, 11 liability subjects of high-risk drug control in hospitals were defined.Hospital management personnel, doctors, nurses, pharmacists, and quality control departments were determined as the core liability subjects; Medical staff's demand for reducing the risk of high-risk drugs was that they required regular high-risk drug knowledge training, followed by pharmacists’ assistance in guiding the use of high-risk drugs. Conclusion Strengthening the training of high-risk drugs for health works and actively promoting the participation of pharmacists in the management and use of high-risk drugs are beneficial to the safe use of high-risk drugs in China.
The pharmacological effects of high-risk drugs are significant and rapid.Improper use can easily lead to serious consequences or even life-threatening condition.In order to reduce the occurrence of drug errors and the incidence of adverse events, it is great significance to strengthen the management of high-risk drugs.The core of high-risk drugs management in healthcare institutions is to control the possibility of high-risk drugs which cause harm to patients during the internal circulation.At present, most healthcare institutions in China use failure mode and effect analysis (FMEA) to carry out high-risk drugs management.With the rapid development of technology and the reform of health care system, FMEA has been unable to meet the comprehensive and precise management of high-risk drugs, and researchers have begun to explore new technologies and methods for the management of high-risk drugs.Among them, sociotechnical probabilistic risk assessment (ST-PRA) can incorporate human, technical factors, and risks quantification simultaneously.But it did not have a very mature application in high-risk drugs management in China.Therefore, this study elaborates and compares the application of FMEA and ST-PRA methods in high-risk drugs management to provide a basis for scientific and effective selection of research methods for high-risk drugs management.
Objective To explore the possible deficiencies in pediatric drug research and provide reference for the drug use in pediatric,by analyzing the literature on pediatric drug use at domestic and international. Methods “Pediatric Drug” was used as the English subject word,and “Pediatric Drugs” was used as the Chinese subject word.The Web of Science core collection database and CNKI were searched respectively.From the three aspects of key words co-occurrence analysis,cited analysis and hotspot change analysis,CiteSpace software is used to analyze the hotspots and trends of pediatric drug literature research at home and abroad from 2009 to 2019. Results A total of 2200 Chinese literature and 2509 English papers were analyzed.Key words co-occurrence analysis showed that the most frequent keywords in Chinese literature were children's drug,rational drug and safe drug.The highest frequent keywords of English literature were children,diagnosis and safety.The cited analysis found that most of the high quoted Chinese literature was about off-label drug use in clinic department,while the English literature focused more on drug development than the investigation of outpatients.The analysis of hotspot changes showed that the clinical research on pediatric drugs in Chinese and English literature increased. Conclusion Compared to drug design, domestic research on pediatric drug use focoues on the analysis of clinical drug use.The state should encourage the research and development of special dosage forms for children's drugs, improve the standards of children's clinical drug use and management is strengthen.
Objective To summarize the characteristics and regularity of adverse drug reactions (ADR) for the children in Hubei province, and to provide a reference for children's clinical drug safety. Methods A retrospective study was performed on 38,425 children's ADR reports, which were collected by Hubei Center for ADR/ADE Monitoring from January 2014 to December 2018.Statistical analyses were performed on the patient's gender, age, basic medication, ADR occurrence, and other reported situations. Results The ratio of males to females in those 38 425 ADR patients was 1.49:1.The composition of patients aged from 0 to 6 was relatively high.The main route of administration was intravenous injection, and the proportion of combined medication was 23.7%.The skin and organs involved in ADR were mainly skin and its annex damage (47.3%), systemic damage (27.1%), and gastrointestinal disorders (18.4%).The highest proportion of serious reports were reported from 12 to 14 years old.ADR reporting personnel were mainly doctors, pharmacists, and nurses. Conclusion Children have serious ADRs, so it is need to pay close attention and strengthen the monitoring during clinical medication, especially for infants and young children.
Objective To explore and evaluate the post-marketing safety warning signals of leuprolide and goserelin, the representative drugs of GnRHa, and to provide references for the safe use of the two drugs. Methods The adverse drug event (ADE) of leuprolide and goserellin received by the US FAERS from the first quarter of 2009 to the first quarter of 2019 were collected, and the adverse drug reactions (ADR) signal mining was performed by reporting odds ratio (ROR) method and proportional reporting ratio (PRR) method.ADR description terms in the reports were standardized with WHO adverse reaction terminology.Signals of adverse reactions which were screened out were analyzed and compared. Results Total 52 ADR signals of leuprolide and 100 ADR signals of goserellin were obtained, of which 17 signals were overlapped.The most specific ADR signals of leuprolide included hilar lymphadenopathy and mediastinal lymphadenopathy; the most specific ADR signals of goserellin included depilation, insomnia, panic disorder, gastric dilatation, and auditory hypersensitivity. Conclusion In this study, ROR and PRR methods were used to explore and compare the adverse reaction signals of leuprolide and goserellin, and to provide references for clinical rational drug use.
Objective To study the mechanisms of low-dose cyclophosphamide (CTX) treatment for condyloma acuminata(CA) on the proliferation and differentiation of keratinocytes in the epidermis of CA. Methods A total of 20 patients with primary CA were selected as CA group,and 8 cases treated with low-dose CTX were selected as the experimental group (CTX group),and 10 normal circumcision patients were selected as the blank control group (NS group).The expression and distribution of epidermal stem cell’s markers including P63,integrin α6 (ITGA6) and marker for keratinocytes K10 were tested and compared among the three groups by using immunohistochemistry. Results The immunohistochemical results showed that levels of P63 and ITGA6 in CA group were significantly higher than those in NS group and CTX group.However,the expression of P63 and ITGA6 in the NS group was similar to that in the CTX group.Moreover,the localization of P63 and ITGA6 in CA group was no more than in the basal layer of epidermis,and even more in the spinous layer near the basal layer compared with the other two groups.In addition,K10 and mature keratinocytes’ marker was lower in CA group,but significantly increased after the low-dose CTX treatment,which was similar to that in NS group.The localization of K10 also was changed among three groups.K10 was localized upon the basal layer and almost negative in the basal layer,which was significantly decreased in the CA group.Interestingly,after a whole course of low-dose CTX treatment,K10 markedly increased compared to the CA group,and distributed upon the basal layer. Conclusion The epidermal stem cells within the CA warts after taking low-dose cyclophosphamide had less ability to proliferate but were more likely to differentiate,which means that low-dose cyclophosphamide treatment may suppress the proliferation of local epidermal stem cells and promote differentiation.
Pneumocystis pneumonia (PCP) is the most common and severe opportunistic infection among patients with human immunodeficiency virus (HIV) and/or acquired immune deficiency syndrome (AIDS).In recent years, the incidence rate of PCP has been increasing in immunodeficiency patients with non-HIV infection due to the wide use of immunosuppressive agents and the development of organ transplant operations.At the same time, studies on PCP in HIV-negative patients have also increased.The epidemiology, pathophysiology, the significance of $\text{CD}_{4}^{+}$T cell count in identifying PCP risk, and its diagnosis and treatment of PCP in HIV-negative patients were reviewed systematically.Some major problems and challenges, which urgently need to be solved, were put forward in order to better understand the clinical research progress of non-HIV patients complicated with PCP.
The advent of immunotherapy has led to significant changes in the treatment landscape of urogenital tumors.Currently, a number of vaccines and immunosuppressive checkpoint inhibitors, such as drugs targeting the programmed death 1 (PD-1), and cytotoxic T-lymphocyte associated antigen (CTLA-4), have been approved for the second-line treatment of a variety of urogenital tumors, including prostate cancer, renal cell carcinoma, and urothelial carcinoma.In addition, there are many ongoing clinical trials aiming at exploring the combined use of immunotherapy and other types of drugs, and biomarkers for predicting the efficacy of tumor immunotherapy.And the role of immune checkpoint inhibitors in first-line and adjuvant treatment were also investigated so as to further improve the effectiveness and accuracy of immunotherapy and expand the beneficiary population.In this review, we summarize the clinical application of immunotherapy in urogenital system tumors, including three different types of urogenital tumors: prostate cancer, renal cancer and urothelial cancer.In addition, perspectives on the future use of checkpoint inhibitors are discussed, including the potential use in combination with other agents, and the identification of biomarkers to guide patient selection and individualization of therapy.
Objective To establish the quality standard of Huanglian Jiangzhi mixture. Methods Rhizoma coptidis and Panax notoginseng in Huanglian Jiangzhi mixture were identified by thin layer chromatography (TLC) methods.The content of Puerarin was determined by high performance liquid chromatography (HPLC).Chromatographic column for the analysis was C18 column (25 mm×4.6 mm, 5 μm), mobile phase was methanol-water (25:75), the detection wavelength was 250 nm, and the flow rate was 1.0 mL·min-1 with column temperature of 30 ℃, the injection volume was 10 μL. Results Berberine hydrochloride and Panax notoginseng could be detected by TLC.The detection of Puerarin had a good linear relationship within the range of 27.15-135.75 μg·mL-1, and the recovery rate was 97.00% (RSD was 1.62%).The average content of three batches of samples was 7.01 mg·mL-1. Conclusion The established method is repeatable and reliable, and can be effectively used for the quality control of Huanglian Jiangzhi mixture.
Objective To establish a high performance liquid chromatographic fingerprint analysis method for Qingxue jiedu mixture to provide experimental basis for its scientific evaluation and quality control. Methods High performance liquid chromatography was performed on an Elite C18 column (4.6 mm × 250 mm, 5 μm), and the mobile phase was acetonitrile-0.05% phosphoric acid for the gradient elution with column temperature of 30 ℃.The detection wavelength was set at 230 nm, and flow rate was 1.0 mL·min-1. Injection volume was 10 μL and the analysis time was 90 minutes.“Chinese medicine chromatographic fingerprint similarity evaluation system” (2010 version) software issued by the National Pharmacopoeia Commission was used for the processing of 10 batches of samples. Results With baicalin’s peak 26 as a reference, a total of 36 common peaks were identified with good resolution.The chromatographic peaks were well separated, and seven chromatographic peaks were identified as gallic acid, protocatechuic aldehyde, catechin, caffeic acid, paeoniflorin, glycyrrhizin, and baicalin. Conclusion The fingerprint method established in this experiment was accurate, simple, stable, and easy to operate, and had strong specificity.It can be used as an effective method for quality control of Qingxue Jiedu mixture.
Objective To establish a high performance liquid chromatography (HPLC) gradient elution method for the determination of gentiopicrin, loganic acid, swertiamain, sweroside, tetrandrine, fangchinoline, nodakenin, notopterol, and isoimperatorin in Linglong ganmao Capsules simultaneously. Methods The separation was performed by HPLC equipped with a ZORBAX SB-C18 (250 mm×4.6 mm, 5 μm) chromatographic column.The mobile phase consisted of methanol-acetonitrile (1:1) - 0.3% acetic acid solution in a gradient elution method.The flow rate was 1.0 mL·min-1 with the detection wavelengths of 240 nm, 280 nm, and 315 nm, and the column temperature was set at 30 ℃. Results A good linear relationship was observed within the range of 36.56-731.20 μg·mL-1 for gentiopicrin, 2.99-59.80 μg·mL-1 for loganic acid, 4.67-93.40 μg·mL-1 for swertiamain, 1.58-31.60 μg·mL-1 for sweroside, 9.94-198.80 μg·mL-1 for tetrandrine, 4.26-85.20 μg·mL-1 for fangchinoline, 10.58-211.60 μg·mL-1 for nodakenin,2.46-49.20 μg·mL-1 for notopterol, and 20.87-417.40 μg·mL-1 for isoimperatorin.The average recovery rates of each detected component of Linglong Ganmao capsules were 100.03%, 98.29%, 98.54%, 97.73%, 99.14%, 98.69%, 99.30%, 97.27%, and 99.62%, respectively.RSDs were 0.79%, 1.36%, 1.12%, 1.61%, 0.96%, 0.81%, 1.00%, 1.27%, and 0.99% (n=9), respectively. Conclusion The method for the simultaneous determination of nine components demonstrated the accuracy and reproducibility, and can be used for quality control of Linglong ganmao capsules.
Objective To establish an ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous determination of four index components in roots and leaves of Herba Taraxaci. Methods The separation was achieved on a Dikma Endeavorsil C18 column(100 mm ×2.1 mm, 1.8 μm)with a gradient elution of 0.1% formic acid (A) and methanol (B) at a flow rate of 0.2 mL·min-1, and the column temperature was 35 ℃.Multi reaction monitoring mode (MRM) mode was used as the detection mode with electro-spray ionization (ESI) as the source for positive ion scanning. Results The linear relationships of coumaric acid, caffeic acid, luteolin, and luteolin-7-O-glucoside were good in the selected concentration range, and the correlation coefficients were all greater than 0.999 1.The average recoveries were from 98.60% to 100.34%, and the RSDs were from 0.44% to 1.62%.The repeatability, stability and precision were good. Conclusion The developed method is rapid, accurate and reliable, and can be used to determine the 4 components and quality control of roots and leaves of Herba Taraxaci.
Objective To study the preparation process of compound Xiecao shuxin dropping pills. Methods Dropping pills were prepared by dropping method.The effects of PEG4000/6000 matrix, drug-matrix ratio, dropping acceleration and liquid temperature on the preparation of the dropping pills were studied.Orthogonal test was conducted with the total scores of appearance, weight difference, and dissolution time as the factors to optimize the best preparation process of compound Xiecao shuxin dropping pills. Results The optimal preparation process of compound Xiecao shuxin dropping pill was as follows: PEG4000/6000 (1:1) was as the matrix, and the ratio of drug to matrix was 1:3.The temperature of the feeding liquid was 90 ℃, and the dropping acceleration was 35 drops per minute, and the temperature range of condensate liquid paraffin was from 5 to 15 ℃. Conclusion The optimized preparation technology is stable and feasible, which can provide necessary reference for the preparation of compound Xiecao shuxin dropping pills.
Objective To investigate the associations between tacrolimus trough concentrations and genetic polymorphisms and new onset diabetes after transplantation (NODAT) among heart recipients. Methods Heart recipients without diabetes before transplantation were eligible for the present study.Clinical data were collected and four single nucleotide polymorphisms (SNPs) of rs2237895,rs5215,rs2276706 and rs8450 were genotyped.NODAT was diagnosed according to the criteria of the American Diabetes Association (ADA).The effect of tacrolimus trough concentrations on NODAT were analyzed using multivariate logistic regression and NODAT risk predictive models were built. Results A total of 101 heart recipients were consecutively enrolled,31 (30.7%) were diagnosed with NODAT.The dose-adjusted tacrolimus trough concentration(C0/D) was significantly higher in the NODAT group than the non-NODAT group (median C0/D 139.3 vs.96.0,P=0.025).Tacrolimus C0/D≥110 ng·mL-1/(mg·kg-1·d-1)[OR=4.52,95%CI (1.63,12.53), P=0.004],age≥45 years[OR=4.99,95%CI(1.65,15.10),P=0.005]and BMI≥25 kg·(m2)-1[OR=3.70,95%CI(1.38,9.93),P=0.009]were risk factors of NODAT.The area under the receiver operating characteristic curve (AUROC) of the model in predicting the NODAT risk increased to 0.788 (P<0.001) when tacrolimus C0/D≥110 ng·mL-1/(mg·kg-1·d-1) was added into predictive model. Conclusion Tacrolimus C0/D [≥110 ng·mL-1/(mg·kg-1·d-1)],age (≥45 years) and BMI[≥25 kg·(m2)-1] were independent risk factors of NODAT.The model built with these risk factors showed a good ability in predicting the risk of NODAT.Moreover,the model could easily identify the high-risk recipients of NODAT after heart transplantation,which would allow more timely preventive interventions to be made.
Objective To compare the distribution and drug resistance of pathogenic bacteria between agranulocytotic and non-agranulocytotic patients with hematologic malignancies and solid tumors. Methods Clinical bacterial strains, isolated from agranulocytotic and non-agranulocytotic patients in the Departments of Hematology and Oncology of the First Affiliated Hospital with Nanjing Medical University from July 1, 2016 to August 31, 2017, were analyzed and compared.The isolated strains were identified by an API system or a VITEK-2 Compact automatic identification system.Antimicrobial susceptibility testing was conducted by VITEK-2 Compact automatic identification system or Kirby-Bauer method.All data were statistically analyzed by SPSS23.0 software. Results A total of 154 and 308 strains of bacteria were isolated from the samples of patients with and without agranulocytosis, and Gram negative bacteria and Gram positive bacteria accounted for 79.9% and 19.5%, respectively.In the blood samples of patients with agranulocytosis, Pseudomonas aeruginosa accounted was significantly higher than that of non-agranulocytotic patients (17.0% vs 5.6%, P<0.05), There were significant difference in the detection rate of all bacterias in sputum samplese between patients with agranulocytosis and non-agranulocytosis (all P>0.05). There were no significant difference in the detection rate of MRSA and methicillin resistant coagulase negative Staphylococcus (MRCNS) between patients with agranulocytosis and non-agranulocytosis (P>0.05). All the Enterococcus and Staphylococcus isolated from both agranulocytosis and non-agranulocytosis patients were susceptible to linezolid and vancomycin.There was no significant difference in the detection rate of CRE between patients with agranulocytosis and non-agranulocytosis (22.7% vs 10.3%, P>0.05). There was no significant difference in the detection rate of non-fermentive bacterial between agranulocytosis and non-arganulocytosis (35.8% vs 24.8%,P>0.05). Conclusion The distribution and drug resistance of pathogenic bacteria between agranulocytotic and non-agranulocytotic patients in our hospital are different from those reported domestic and abroad.The appropriate and effective empirical anti-infective drugs should be selected according to the distribution and drug resistance characteristics of pathogenic bacteria in local area.
Objective Clinical pharmacist participates in outpatient follow-up combined with therapeutic drug monitoring (TDM) to improve pharmaceutical care. Methods Clinical pharmacist participated in the diagnosis and treatment of tacrolimus related seizure in a renal transplant patient.An individualized regimen was sorted out and analyzed for the medication, and the treatment plan was timely adjusted by TDM. Results The seizure was caused by high concentration of tacrolimus. Serious adverse reactions were completely alleviated through the optimization of immunosuppressive regimen under the effort of clinical pharmacist and surgeon.No adverse events associated with the immunosuppressants were identified during the follow-up. Conclusion It highly suggests that clinical pharmacist could actively involve in the outpatient follow-up to evaluate the efficacy and tolerability of immunosuppressive medication and design the individualized dosing regimens.It will largely contribute in the improvement of pharmaceutical care and in the safety and effectiveness of drug use in patients after renal transplantation.
Objective Decision tree optimization of personalized medicine for voriconazole,to provide better suggestions for decision-making of voriconazole,and to ensure the efficacy and safety of voriconazole. Methods The clinical pharmacist carefully considered the relevant factors(liver function,combined medication,genotype) to obtain relevant data,integrated the information,establish the decision tree for individualized administration of voriconazole and made the initial plan according to the decision tree,and then adjusted it later based on the blood drug concentration. Results According to the decision tree model,a comprehensive analysis of related factors before and after the administration of voriconazole was conducted,and a comprehensive trade-off was made to provide safe and effective medication recommendations for clinical use. Conclusion The application of voriconazole decision tree can provide a convenient and accurate medication plan for the clinic,ensure the efficacy and safety of voriconazole,and reflect the work value of clinical pharmacists.
Objective To retrospectively analyze the uses of antibacterial drugs in maternity and child health care hospitals in Hubei province, and to provide scientific basis for clinical rational drug uses. Methods The data synchronized per year of 76 maternity and child health care hospitals in Hubei province from January 2012 to December 2019 were collected and compared, including the number of varieties, defined daily doses (DDDs), the ratio of antibacterial drugs usage, prophylactic application of antibacterial drug for type I incision, etiology examination rate, and consultation for the use of special class of antibacterial drugs. Results After the special rectification of antibacterial drug on clinical use, the number of varieties was maintained about 30 types from 2012 to 2019.The ratio of antibacterial usage in outpatient was reduced from 29.4% to 19.2%.The ratio of antibacterial drugs usage from emergency department was reduced from 15.2% to 13.1%.The ratio of antibacterial drugs usage in inpatient was reduced from 68.2% to 58.4%.The DDDs of antibacterial drug was decreased from 56.3 to 38.2.The microbial inspection rate of antibacterial drug was obviously increased, in which the microbial inspection rate of special restricted class of antibacterial drugs was increased from 33.4% to 62.2%.The consultation rate of special restricted class of antibacterial drugs was increased from 56.1% to 81.1%.The ratio of prophylactic use of antibacterial drug in type I surgery was decreased from 48.4% to 25.2%, and the ratio of rational selection of prophylactic use in type I surgery was increased from 73.4% to 89.6%.The ratio of rational timing of prophylactic use of antibacterial drug in type I surgery was increased from 62.1% to 76.5%.The ratio of prophylactic use of antibacterial drugs in surgery less than 24 h was increased from 51.8% to 72.4%. Conclusion The special rectification activity on antibacterial drugs carried out in maternity and child health care hospital of Hubei province has achieved remarkable outcome.However, there are still some indicators of antibacterial drugs use that have not reached the national standard, and further measures should be taken to improve the safety and rationality of antibacterial drugs use.
Objective To investigate the current situation of orphan drugs used by doctors in Tangshan, a medium-sized city in China. Methods A self-designed questionnaire was used to investigate the status quo of drugs for rare diseases among 2038 on-job clinicians in 14 public grade II general hospitals and above in Tangshan City. Results Total 34.2% of patients with rare diseases are using domestic medicine, and 34.5% of the patients with rare diseases had more than 50% of medical insurance reimbursement. 5.8% of the patients with rare diseases had received social medicine donation, and 53.1% of the patients with rare diseases bought the medicines from hospital pharmacies. Conclusion Patients with rare diseases in Tangshan City had a heavier burden of medication and poor accessibility of the medicine.
