中国科技论文统计源期刊 中文核心期刊
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
Objective To investigate the effects and molecular mechanisms of gallic acid on radiosensitivity of human nasopharyngeal carcinoma cells in vitro. Methods Fractionated radiotherapy with multiply sub-lethal doses of deep X-ray exposure to nasopharyngeal carcinoma cells was employed to establish the radio-resistant nasopharyngeal carcinoma cell line;radiation clonal survival assay was used to identify radiosensitivity of nasopharyngeal carcinoma cell lines;MTT assay was used to detect the effect of gallic acid on cell viability;apoptosis was observed by fluorescence microscopy with Hoechst 33258 staining and flow cytometry with 7-AAD and Annexin V-FITC staining;The expression levels of STAT3,PD-L1,and phosphorylated STAT3 and phosphorylated c-Jun in HNE1-IR cell line after gallic acid treatment with the combination of radiotherapy were detected by Western blot. Results Gallic acid had similar cytotoxicity to radioresistant nasopharyngeal carcinoma cell line HNE1-IR and radiosensitive HNE1 after the treatment (IC50 values: 12.58 and 11.17 μmol·L-1,respectively);low doses of gallic acid significantly increased the radiotherapy sensitivity in radioresistant HNE1-IR cells when compared with the control in vitro (linear quadratic model,radiation protection factor =1.421,t=2.714,P<0.05);with the low dose of gallic acid combined with radiotherapy after 72 h,apoptosis rate in HNE1-IR cell line (Δ apoptosis rate=6.1%) was significantly increased when compared with control (Δ apoptosis rate =14.2%) by Hoechst 33258 staining under fluorescent microscope (t=4.799,P<0.05);the results of apoptosis rate by gallic acid treatment were confirmed by double staining of flow cytometry (Δ apoptosis rate of HNE1-IR 13.7% vs Δ apoptosis rate of HNE1 10.3%,t=2.231,P<0.05);the levels of phosphorylated STAT3 and c-Jun in HNE1-IR cell line were down-regulated while protein level of PD-L1 was not significantly changed after the treatment of gallic acid combined with radiotherapy. Conclusion Gallic acid may exert a radiosensitizing effect in nasopharyngeal carcinoma cells through inhibiting STAT3 and c-Jun,and inducing apoptosis,which may be a promising candidate agent for radiosensitization.
Objective To preliminarily explore effects of berberine on the glucagon-like peptide-1 (GLP-1) secretion in type 2 diabetic rats,and to provide the theoretical basis for further clarifying the antidiabetic molecular mechanism of berberine. Methods The model of type 2 diabetic rat was established by a high-fat and high-sugar diet combined with the injection of streptozotocin (STZ).The experiment was divided into normal control group,model control group,liraglutide group,low-dose berberine group,and high-dose berberine group.Blood glucose was measured by blood glucose meter in different periods.The contents of glycosylated hemoglobin (HbA1c) and GLP-1 were detected by enzyme-linked immunosorbent assay (ELISA).The content of the microbiota in feces was detected by quantitative polymerase chain reaction (Q-PCR).The histology of pancreas was observed by hematoxylin-eosin (HE) staining.The mRNA expressions of glucagon-like peptide-1 receptor (GLP-1R),short chain fatty acid receptor 43 (GPR43),G protein coupled bile acid receptor 1 (TGR5),proglucagon (GCG),and proconvertase 1/3 (PC1/3) in colon tissue were assayed by reverse transcriptase polumerase chain reaction (RT-PCR).The protein expressions of insulin and nuclear factor kappa-B (NF-κB) were determined by immunohistochemistry.The protein expression of GLP-1 in colon tissue was assayed by Western blotting. Results Compared with the model control group,berberine increased the levels of Fusobacterium and Lactobacillus,ameliorated the oral glucose tolerance,reduced the level of HbA1c,increased the mRNA expressions of GPR43,TGR5,GCG and PC1/3,downregulated NF-κB protein expression,and upregulated GLP-1 and insulin secretion. Conclusion Berberine can ameliorate blood glucose by increasing the activity of GPR43 and TGR5,upregulating the mRNA expressions of GCG and PC1/3,and promoting GLP-1 and insulin secretion.
Objective To investigate the duodenum absorption characteristics of zolpidem tartrate and explore the changes between normal SD rats and simulated weightlessness SD rats. Methods The concentrations of zolpidem tartate in single pass intestinal perfusion (SPIP) model were determined by HPLC.The effective permeability coefficient (Peff) and absorption rate parameter (Ka) were calculated. Results The duodenum absorption characteristics of zolpidem tartrate in simulated weightlessness SD rats and normal rats had a significant difference (P<0.05).The Peff and Ka of duodenum were decreased in simulated weightlessness groups. Conclusion The Peff and Kaof duodenum in simulated weightlessness SD rats were lower than those in normal rats.The simulated weightlessness had a great influence on the absorption of zolpidem tartrate in the duodenum of SD rats.These results suggest that it is necessary to adjust the dosage of zolpidem tartrate after entering the weightlessness environment.
Objective To investigate the effects and mechanisms of andrographolide (AG) on the pathological injury and inflammatory reaction of cardiopulmonary tissues in lipopolysaccharide (LPS) induced sepsis rats. Methods Rats were randomly divided into six groups: normal control group,model control group (LPS group),low,medium and high dose AG groups (LPS+AG 2.5 mg,LPS+AG 5 mg and LPS+AG 10 mg),and linezolid group (LNZ 25 mg). AG solution was given to rats at 8 h and 16 h after the establishment of the rat model.The normal control group and the model control group were given the same amount of 0.9% sodium chloride colution,while linezolid group was given linezolid (LNZ).After 24 hours,the ratio of wet to dry weight (W/D) of lung was determined;the histopathological changes of heart and lung were detected by HE staining;the contents of heart injury markers and inflammatory cytokines were detected by ELISA;and the expressions of inflammatory pathway-related proteins were detected by Western blot.The rats were randomly divided into five groups: normal control group,model control group,LPS+AG group (AG 10 mg),LPS+pyrrolidine dithiocarbamate (PDTC) group (PDTC 50 mg),and LPS+PDTC+AG.The above experiments were duplicated. Results AG could improve the pathological injury of heart and lung in sepsis rats,and the contents of creatine kinase isoenzymes (CK-MB),troponin I (cTnI),myoglobin (Mb),lung wet/dry weight ratio,serum levels of tumor necrosis factor-alpha (TNF-α),interleukin-1beta (IL-1β),interleukin-6 (IL-6) and macrophages were decreased in high and medium doses (P<0.05 or P<0.01).The expression levels of cytoinflammatory protein-2 (MIP-2) and high mobility group protein B1 (HMGB1),toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-kappa B) p65 in cardiopulmonary tissues (P<0.05 or P<0.01).Finally,AG could increase the regulatory effects of PDTC,a specific inhibitor of NF-kappa B,on the pathological injury of cardiopulmonary tissue,wet/dry weight ratio of lung,the content of cardiac damage markers,the release of inflammatory cytokines,and the expression of inflammatory pathway protein in sepsis rats (P<0.01). Conclusion AG can inhibit LPS-induced cardiac and pulmonary pathological injury and inflammatory response in septic rats,and its mechanism is related to the inhibition on the activation of HMGB1/TLR4/NF-kB signaling pathway.
Objective To reveal the characteristics and trends of research hotspots in pharmacoepidemiology. Methods Chinese and English terms of Pharmacoepidemiology were used as key words to be searched in CNKI and PubMed.BICOMB software was used to analyze publication years,authors' distribution,and source journals' distribution.SPSS software was used for co-word clustering analysis and establishment of strategic coordinate map. Results The number of foreign literatures was significantly more than Chinese literatures,and the domestic pharmacoepidemiology research needs to be further accumulated.There were few high output authors in pharmacoepidemiology studies,and the core author group has not been formed yet.The results of co-word clustering analysis and strategic coordinates show that there were both similarities and differences in the focus of pharmacoepidemiology research in domestic and abroad.There were also differences in the maturity of research hotspots."Pharmacovigilance and adverse drug reactions" was the only in-depth and mature research theme in China. Conclusion The domestic pharmacoepidemiology research is still in the starting stage,and there is need systematic and further research in the branch of pharmacoepidemiology study.
Medication adherence is one of the important factors affecting the treatment effect of patients.This paper summarized the definition,influencing factors,intervention methods,especially the assessment methods of medication adherence through literature review so as to provide references for the study of medication adherence.The influencing factors of medication adherence are complicated,and the intervention can be carried out in a variety of ways.The assessment methods of medication adherence include objective assessment method and subjective assessment method,and different methods have their respective applicable scopes.At present,many reliable assessment methods of medication adherence have been developed and used,but a convenient,economical,and effective universal method need to be developed in the future.
Objective To study the incidence rate and drug distribution of drug-induced liver injury (DILI) in hospitalized patients,and to compare the case characteristics of patients by Hy's Law and patients in general DILI. Methods Using the "ADE active surveillance and assessment system-Ⅱ" (ADE-ASAS-Ⅱ) retrospectively monitored the electronic medical data of inpatients in the First Medical Center of the PLA General Hospital in 2019,and automatically identified the patients who meet the standards and alarmed in the study.After the alarm,patients were manually evaluated one by one,and the positive patients were divided into serious and general groups according to Hy's Law,and the differences between two groups in gender,age,hospitalization time,and mortality rate were compared and analyzed. Results In 2019,there were 201 299 hospitalized patients,among which 156 570 patients were with complete indicators,and 499 patients were DILI positive cases,and the incidence rate was 0.32%.The top three major pathogenic drugs were anti-infective drugs (44.69%),anti-tumor drugs (12.63%),and non-steroidal anti-inflammatory drugs (10.22%).Cefoperazone,voriconazole,and meropenem are the most frequently suspected varieties.There were 114 severe patients in compliance with the Hy's Law,of which 10 patients died with a mortality rate of 8.77%.Compared with general DILI patients,severe patients are older (56.32 years vs 49.35 years,P=0.005),and hospital stay is also longer (39.35 days vs 30.86 days,P=0.026),and mortality is higher. Conclusion The incidence of DILI is low.With the help of ADE-ASAS-Ⅱ,large-sample monitoring research can be carried out efficiently and conveniently.Manual identification based on system monitoring results greatly reduces the workload of preliminary screening.The results obtained are accurate and have strong reference value.In the comparison of epidemiological survey results in different regions,patients who meet Hy's Law have a higher mortality rate and can be used for post-market research and risk monitoring programs.
Objective To analyze the safety issues of analgin found in clinical application in 9 public hospitals of Qingdao,such as Central Hospital and Municipal Hospital,in recent past 10 years,so as to provide data reference for strengthening the supervision of clinical application of old drugs with high incidence of adverse reactions. Methods According to the data screened in the drug warning system,the adverse reactions of analgin-related preparations were analyzed,and the risk of analgin was evaluated.The regulatory strategy of old drugs with high incidences of adverse reactions was also formulated. Results There were 11 kinds of analgin and its related preparations listed in China,involving more than 1000 manufacturers.The amount of money spent and the proportion of analgin-related preparations used decreased in 9 hospitals during 2008-2018.The incidences of adverse events in clinical use of analgin were higher,which mainly manifested as local and systemic allergic reactions.Serious adverse reactions mainly occurred in the combination of antipyretic and analgesic indications.In the course of combined treatment,the main cause of adverse drug events was higher adverse drug reactions of the drug itself,followed by combined drug use and irrational drug use beyond the instructions. Conclusion Adverse events of analgin and its related preparations occur frequently.Combining with the international drug regulatory strategy,drug regulatory authorities and health commissions should properly control the use of analgin to promote safe,effective,rational,and economical drug use.
With the progress of diagnosis and treatment technology and drug research and development,the treatment methods of malignant tumors have been increasingly abundant.From empirical medicine to evidence-based medicine and from precision medicine to integrated medicine,the therapeutic mode of cancer is constantly upgraded.Traditional treatments would no longer meet the current needs completely.The immuno-targeted therapy,just being in the ascendant,is impacting the traditional three classic treatments,surgery,radiotherapy,and chemotherapy.Under the comprehensive treatment background,it is of great significance to explore an effective,low-toxic,low-damaging,and sustainable treatment mode,especially for advanced cancer.The "green therapy" for tumors aims at maintaining patients' quality of life and modernizing the application of external therapies of traditional Chinese medicine (TCM). In combination with the guidance of Yin-Yang theory,argon-helium cryoablation,a minimally invasive treatment,can directly destroy the tumor with minimal side effects and effectively reduce side reactions of modern medical treatment at the same time,hence,achieving the dual effects of both and improving the quality of life and extending survival.In this paper,it reviews the concept of "green therapy" of tumors and the associated researches,and further explores the new treatment mode of cancer with integrating traditional Chinese and Western medicines based on the real clinical cases and supporting the effectiveness of argon-helium cryoablation combined with TCM external therapies.
Objective To observe the efficacy and safety of cisplatin circulating hyperthermic perfusion chemotherapy in the treatment of primary hepatic carcinoma with malignant peritoneal effusion. Methods A total of 86 patients with primary hepatic carcinoma with malignant peritoneal effusion admitted to the department of oncology of the NO.3 People's Hospital of Hubei province from June 2018 to July 2019 were selected.The patients were randomly divided into treatment group and control group with 43 cases each.All patients underwent central venous catheter bilateral peritoneal puncture,drainage and catheterization.Then all patients received intraperitoneal perfusion with 3000 mL 0.9% sodium chloride soution+40 mg of cisplatin+5 mg of dexamethasone.In the treatment group,the bilateral abdominal drainage tube was connected with an inlet and outlet of the intraluminal tumor thermal circulation perfusion machine,and the chemotherapy was performed.In the control group,the drug was slowly injected from one side of the abdominal drainage tube,while the perfusion fluid was slowly released from the contralateral drainage tube.The perfusion time of both groups was 60-90 min,and the patients were treated once a week for 4 weeks.The improvements of indicators,such as efficacy of abdominal effusion,KPS score,survival rate,tumor marker (CEA,AFP and CA125),liver function (ALT,AST and GGT),and occurrences of adverse reactions were compared between two groups. Results The total effective rate of abdominal effusion absorption in the treatment group (93.0%) was higher than that in the control group (76.7%) (P<0.05).After the treatment,the KPS score and survival rate,tumor markers,and liver function were better than those before the treatment,and the treatment group was significantly better than the control group (P<0.05).The adverse reactions,such as myelosuppression impaired liver and kidney function and digestive tract symptom were mild in the two groups,and the difference was not statistically significant. Conclusion Cisplatin circulating hyperthermic perfusion chemotherapy could improve the clinical efficacy of primary hepatocellular carcinoma with malignant peritoneal effusion,reduce the level of tumor markers,improve the liver function,improve the quality of life,and extend the survival period to a certain extent.The adverse reactions occurred less,too.The treatment is worthy of clinical application.
Objective Due to its advantages in improving drug solubility, in vivo targeted delivery, nanomedicine has become a hotspot in the field of pharmacy. With the continuous research of nanotechnology in the field of medicine, it is also accompanied by the progress and improvement of analytical methods. This paper is summarized the new developments in classical analytical methods such as particle size, morphology, encapsulation efficiency, and drug loading of nanomedicines, and new analytical techniques and methods that have appeared in recent years, providing technical methods and research ideas for the in-depth analysis and development of nanomedicines and carriers.
Objective To develop a HPLC method for the simultaneous determination of seven alkaloids (6-Hydroxy-β-Carboline-1-carboxylic acid,β-Carboline-1-carboxylic acid,β-Carboline-1-propanoic acid,3-Methylcanthin-5,6-dione,4-Methoxy-3-methylcanthine-5,6-dione,5-Hydroxy-4-methoxycanthin-6-one,4,5-Dimethoxycanthin-6-one) in Kumu injection. Methods The chromatographic analysis were performed on a Phenomenex Gemini C18 column (4.6 mm×250 mm,5 μm) with the gradient elution solvent system composed of methanol and 30 mmol·L-1 aqueous ammonium acetate (adjusted with glacial acetic acid to pH 4.5).The flow rate of the mobile phase was 1.0 mL·min-1with the column temperature of 30℃,and the detection wavelength was set at 254 nm. Results These seven alkaloids were showed good linearities (r≥0.999 9)within the concentration ranges tested (1.00-30.00,5.10-153.00,0.76-22.80,0.38-11.40,0.24-7.20,0.40-12.00,0.10-3.00 μg·mL-1).The RSD was less than 3% and the RSD was stable in 48 h at room temperature.The average recoveries were 99.22%~101.65% with the RSD between 0.82%-2.21%. Conclusion The method is simple,accurate and repeatable,which can be used for the quality evaluation of Kumu injection.
Objective To prepare sustained-release microspheres of poly (lactic-co-glycolic acid) copolymer (PLGA) using quercetin as a model drug,and to investigate its particle sizes and its distribution,morphology,encapsulation efficiency,drug loading,and in vitro release properties. Methods SPG membrane emulsification method was used to prepare microspheres,and a single factor method was used to optimize the formulation.Particle size analyzer was used to detect the particle sizes and distribution of the microspheres.Optical microscopy was used to observe the morphology of the microspheres.The encapsulation efficiency and drug loading of the microspheres were determined by UV spectrophotometry.The in vitro release behavior of quercetin microspheres was investigated by a direct release method and ultracentrifugation. Results The surface of the prepared quercetin microspheres was smooth and round,and the size was small (0.623 ± 0.05)μm;the encapsulation efficiency was high in 91.61%,and the drug loading was 6.97%;the in vitro release was gentle with no burst release effect. Conclusion The surface morphology of quercetin microspheres prepared by formulation optimization was round.Its particle size was uniform,and the encapsulation efficiency was high.The release was gentle in vitro,and the process reproducibility was good.
Objective To establish and implement hazard analysis and critical control point (HACCP) in the production process of Ejiao for the quality and safety. Methods According to GB/T 27341-2009 Hazard Analysis and Critical Control Point (HACCP) system - General requirements for food processing plant and DBS37-xxxx2011 Shandong province food safety local standard on Ejiao,the potential hazards of every step in the production of Ejiao were analyzed and determined from the perspectives of biology,physics,and chemistry,by which the Critical Control Points (CCPs) were identified.The effective measures of each CCPs were formulated to control the quality and safety. Results HACCP system was implemented in the whole chain of Ejiao,such as procurement,production,and storage.The sensory and physical and chemical indicators were improved.Moreover,the microbial indicators were significantly enhanced,which is statistically significant for the quality and safety of Ejiao. Conclusion With the introduction of HACCP,the production process of Ejiao is more standardized,which effectively promotes the control on food safety.
Objective To evaluate the efficacy,safety and economy of pirfenidone in the treatment of idiopathic pulmonary fibrosis based on rapid health technology assessment (HTA),so as to provide evidence-based basis for clinical decision. Methods Data from Pubmed,Embase,the Cochrane Library,CNKI,Wanfang and VIP were retrieved,and the related HTA websites and databases were searched.The results were qualitatively analyzed after 2 independent interviewers screened the literature,extracted the data,and evaluated the quality. Results A total of 2 HTA,12 systematic reviews,and 2 economic evaluations were included.The efficacy of pirfenidone in the treatment of idiopathic pulmonary fibrosis was superior to the placebo,but there was no significant difference in safety.There was no significant difference in the efficacy of pirfenidone in the treatment of idiopathic pulmonary fibrosis compared with nintedanib.The economic evaluation was carried out in the UK and France,so the results need to be further assessed. Conclusion Pirfenidone has good efficacy and safety in the treatment of idiopathic pulmonary fibrosis,but it is necessary to carry out further economic research in China.
Objective Through the establishment of the Markov model, the pharmacological economic evaluation of tenofovir alafenamide and tenofovir disoproxil for the first-line treatment of chronic hepatitis B was conducted to provide evidence for clinical drug use. Methods The Markov model was established with reference to drug prices, treatment costs, and health utility values. The effectiveness and economics of the two programs were evaluated and sensitivity analysis was performed. Results The composition of tenofovir alafenamide was 1 077 244.03 yuan, 7.89QALYs was obtained, and the effect of tenofovir disoproxil was 932 456.65 yuan, and 7.48QALYs was obtained. The incremental cost-effective ratio was 353 139.95 yuan. Conclusion Compared with the tenofovir dipivoxil group, the tenofovir alafenamide group can achieve longer survival results, but its incremental cost effect is greater than 3 times GDP per capita, and has no economic benefit.
Objective To evaluate the impact of key monitoring drug management on the consumption and rational use of drugs,and to provide a basis to promote and improve key monitoring drugs management policy. Methods Data regarding DDDs and consumption proportion of key monitored drugs in our hospital from January 2017 to December 2018 were collected.Combining with comments on prescription,we assessed trends of consumption and rationality of key monitored drugs by using an interrupted time series design and segmented regression analysis. Results After the management implementation,the significant downward trends of DDDs and consumption proportion in key monitored drugs were observed (slope:-15 774.78,P=0.003;slope:-0.005 119 5,P=0.000).The rates of qualified prescriptions were significantly increased (P=0.009) with statistic difference in upward trend (slope: 0.009 299 2,P=0.000). Conclusion Key monitoring drugs management significantly reduced the use of monitored drugs and promoted the rational use of drugs in the monitoring catalog.
Objective To investigate the quality of intravenous infusions prepared by the dispensing robot used in the PIVAS of our hospital to ensure the safety of clinical medications. Methods The clinically representative hemostatic drug corbazochrome sodium sulfonate infusion prepared by the dispensing robot was selected as a research object.The residual amount,insoluble particles,bacterial endotoxins,and sterility were examined for five consecutive days. Results The mean value of sample residue was 0.15 mL (less than the limit of 0.2 mL).Insoluble particles,bacterial endotoxin,and sterility inspection were in compliance with the regulations. Conclusion The infusion prepared by the dispensing robot meets the quality standards,which can ensure the safety of clinical medication and provide a theoretical basis for the large-scale application of the dispensing robot in China's PIVAS.
Objective To evaluate the bioequivalence (BE) of two types of isosorbide mononitrate sustained release capsules (50 mg) in Chinese healthy volunteers. Methods A total of 56 healthy subjects (28 each in the fasting and post-prandial groups) were enrolled in the study,using a single-dose,randomized,open-label,two-period crossover design for the treatment.The plasma concentrations of isosorbide mononitrate were measured by LC-MS/MS.The pharmacokinetic parameters were calculated,and the 90% confidence intervals (CI) of the geometric mean ratio (test/reference) of the parameters were obtained by the analysis of variance on logarithmically transformed data with WinNolin 8.1. Results The main pharmacokinetics parameters of the test and reference administered fasted subjects were as follows: Cmaxwere (508.46±149.25) and (555.32±94.05) ng·mL-1;AUC0-t were (7 094.47±1 543.14) and (7 471.03±1 188.86) h·ng·mL-1;AUC0-∞were (7 249.53±1594.16) and (7 625.27±1 242.10) h·ng·mL-1;tmax were (6.94±1.15) and (7.02±1.25) h;t1/2 were (5.66±0.66) and (5.63±0.60) h.Under fasting conditions,the 90% confidence intervals of Cmax,AUC0-tand AUC0-∞for the test/reference geometric mean ratio were (99.91~105.55)%,(98.85~103.54)%,and (98.89~103.70)%;Under fed conditions,the 90% confidence intervals of Cmax,AUC0-tand AUC0-∞ for the test/reference geometric mean ratio were (88.54~97.23)%,(95.21~99.48)%,(95.12~99.55)%. Conclusion The test product was equivalent to the reference product in subjects under fasting and post-prandial conditions.
Objective To explore the key points of pharmaceutical care in the treatment of patients with chronic myeloid leukemia combined lung adenocarcinoma. Methods The treatment using dasatinib and icotinib for a patient with chronic myeloid leukemia combined lung cancer was monitored.The food-drug interaction and the adverse reactions were analyzed and individualized pharmaceutical services were provided for the patient. Results In this case,CYP3A4 inhibitors and inducers should be reduced or avoided.Pleural effusion probably was associated with dasatinib.Fever and musculoskeletal pain were related to icotinib.It was recommended to replace dasatinib with imatinib,and replace icotinib with afatinib. Conclusion Clinical pharmacists could provide individualized pharmaceutical care for patients with chronic myeloid leukemia and lung cancer through the pharmaceutical care of targeted drug combination therapy.
Objective To provide insights for clinical pharmacists to take part in the clinical practice of patients with special tumors through the analysis and discussion of drug treatment process of neoadjuvant chemotherapy for the patient with pregnancy-associated breast cancer (PABC). Methods According to a case of PABC who received neoadjuvant chemotherapy during the pregnancy and evidence-based evidence,the clinical pharmacist analyzed and discussed the timing of chemotherapy,the choice of chemotherapy regimen,the adjustment of chemotherapy drugs,chemotherapy dose,and antiemetic scheme,and performed pharmaceutical care of chemotherapy-related adverse reactions. Results The clinical pharmacist recommended the chemotherapy regimen being adjusted to epirubicin combined with cyclophosphamide,using ondansetron alone to prevent nausea and vomiting,and monitoring gastrointestinal reaction,myelosuppression,cardiotoxicity and fetal status,etc.The course of chemotherapy was smooth with no obvious adverse reactions and the fetus was in good condition. Conclusion The participation of clinical pharmacists in clinical treatment practice and pharmaceutical care of patients with breast cancer during pregnancy is conducive to improve the safety and effectiveness of drug treatment.
Objective To introduces a case of a patient with pulmonary legionella pneumophila infection after liver transplantation and discusses the role of clinical pharmacists. Methods Clinical pharmacists fully involved in the anti-infectious treatment of a case with pneumonia after the liver transplantation.The patient had a fever of unknown cause after the liver transplantation.The clinical pharmacist participated in the consultation for many times and assisted the doctor to make medication plan before the pathogen was confirmed.After the identification of Legionella pneumophila pneumonia,the infection site and drug interaction were comprehensively considered to optimize the anti-infection treatment plan and guide the medication course.In addition,in the course of ward round,clinical pharmacists gave timely medication guidance to patients,and put forward reasonable solutions to avoid the decline of drug effect caused by drug interaction. Results The anti-infection treatment was effective,and the patient was cured and discharged from the hospital. Conclusion Clinical pharmacists deeply participate in the treatment of patients,assist doctors to optimize the treatment plan,reduce the irrational use of drugs,improve the effectiveness and safety of drug treatment,shorten the length of stay of patients,and indirectly reduce the cost of hospitalization.
Objective To analyze the status and characteristics of adverse drug reactions(ADRs)induced by ixazommib,and to provide references for the clinical medication. Methods ADRs of ixazommib reported by medical science journals were collected and analyzed statistically from CNKI,VIP,Pubmed,Medline,and Web of Science database from Nov.2015 to Jan.2020. Results A total of 10 ADRs were identified and included in the analysis.Patients at the age between 61 and 80 years showed the highest incidences (n=7).ADRs of ixazommib frequently occurred within 6 weeks after the medication (n=8).Main clinical manifestations were disorders of skin,appendages (n=5),and disorders of hematologic (n=2).Moreover,there were new serious adverse reactions,for example,thrombotic microangiopathies (TMA),progressive multifocal leukoencephalopathy (PML),acute pancreaoitis (AP),and cardiotoxicity. Conclusion Physicians and pharmacists should pay more attention to the safety monitoring of ixazommib during the medication,especially for the new serious adverse reactions,and carefully assess the risk of treatment of re-administration in order for the safe and effective medication.
Objective To explore the factors influencing hospital pharmacist's job satisfaction and its correlation with career satisfaction in the secondary and tertiary hospitals in Henan province. Methods A questionnaire survey of the hospital pharmacist's job satisfaction which based on the Hospital Pharmacist's Job Satisfaction Scale established in the previous study and career satisfaction were conducted through the Questionnaire Star System. The questionnaires were distributed and received through the hospital pharmacists work group. The data were analyzed by Excel and SPSS 23.0. Results Total 472 valid questionnaires were received. The Cronbach's Alpha coefficients of the job and career satisfaction questionnaires were 0.977 and 0.718. The validity of coefficients of scale were 0.976 (P<0.01) and 0.874 (P<0.01). The personal factors which significantly influenced hospital pharmacist's job satisfaction were age, highest education, professional title, marital status, and status of children. The work factors were the hospital grade, the working characteristics, the work shift system, and the working hours per week. Moreover, the hospital grade, the working characteristics, and the work shift system also affect the hospital pharmacist career satisfaction. The highest correlation with career satisfaction is "remuneration and benefits", followed by "the growth and development". The weakest correlation with career satisfaction is "work conditions". Conclusion The "remuneration and benefits" and "growth and development" are the most important factors affecting the secondary and tertiary hospitals pharmacist career satisfaction in Henan province. The suggestions to increase the job and career satisfaction of hospital pharmacists were establishing a more fairness payment distribution pattern, increasing the involvement in clinical activities among hospital pharmacists, and improving the working conditions.
