中国科技论文统计源期刊 中文核心期刊
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
, 周绪红
人体呼吸道黏液纤毛清除系统是人体抵抗雾霾的主要防御系统,但持续暴露于严重的污染空气中时,该系统也难以阻挡雾霾中有毒有害气体和致病微生物侵入支气管和肺泡,甚至入血入脑,从而危害人体健康。雾霾主要影响呼吸系统和心血管系统,甚至致癌。雾霾极易引起咽喉炎、过敏性鼻炎、鼻窦炎、气管/支气管炎、哮喘、慢性阻塞性肺疾病等疾病。新型黏液溶解性祛痰药桉柠蒎中的桉油精、柠檬烯及α-蒎烯具有抗菌、抗炎、止咳、祛痰和平喘等作用,当其作用于黏液纤毛清除系统时,可改善和恢复黏液纤毛系统功能,解除黏液纤毛清除系统障碍,促进黏痰稀释、溶解和排出。上述作用有助于雾霾中有害颗粒物的排出,有助于抵抗雾霾中致病微生物的侵袭,有助于雾霾相关疾病的治疗。
随着我国工业化、城镇化以及化石能源消费和机动车数量的持续快速增长,许多城市雾霾天气频发。雾霾对人体健康的影响以及如何防霾治霾引起了全社会的空前关注。
雾霾主要影响呼吸系统和心血管系统,致癌症和早死。 严重的雾霾天,携带细菌、病毒、重金属、化学物质等有毒有害气体的细颗粒物可能通过上呼吸道进入细支气管和肺泡,甚至入血入脑,进而影响人体健康。
人体呼吸道被覆着黏液纤毛清除系统,该系统由纤毛上皮层及其上方的黏液毯构成,从鼻腔直至终末细支气管,都衬有纤毛上皮细胞,而且纤毛总是向头侧定向摆动,推动黏液清除异物和病原体。此外,副鼻窦、耳咽管、中耳、咽等处亦被覆有纤毛上皮细胞。鼻腔黏液纤毛清除系统的功能取决于纤毛的运动功能和黏液毯的流变学性状,纤毛运动的少量改变即可对黏液运动产生显著影响[10]。但黏液纤毛清除系统的功能易受呼吸道疾病和气道局部炎症的影响,雾霾会诱发和加重呼吸道疾病及其炎症病理改变,使黏液纤毛清除功能障碍,不利于雾霾的排出和相关疾病的治疗。
目前上市的新型黏液溶解性祛痰药如桉柠蒎肠溶软胶囊,有效成分桉油精、柠檬烯和α-蒎烯分别提取自桃金娘科桉属植物、芸香科桔属植物和松科松属植物。与氨溴索、愈创木酚甘油醚、
雾霾中的过敏源、致病微生物、有毒有害气体、粉尘等可致、可诱发咽喉炎、过敏性鼻炎、鼻窦炎、气管-支气管炎、哮喘、COPD等呼吸道疾病。雾霾期间,相关疾病门诊患者明显增多。这些疾病有着共同的特点,即呼吸道黏膜呈慢性炎症病理改变,黏液分泌增加,黏液纤毛清除功能降低,炎性分泌物难以咳出,细菌借机繁殖,黏膜炎症病理改变进一步加重,黏液纤毛清除系统功能障碍,炎症分泌物增多黏稠,更难排出,如此形成炎症的恶性循环。
桉柠蒎中的桉油精、柠檬烯和α-蒎烯具有抗菌、消炎、止咳、祛痰和平喘作用,对致病菌有抑制作用,可减轻炎症反应,阻抑炎症进展;其抗菌抗炎作用可加强抗菌药物和抗炎药物的作用,有助于致病菌的清除,减轻炎症反应;桉柠蒎可碱化并溶解黏液,降低黏液黏度,刺激纤毛摆动,加速纤毛运转,有利于黏痰稀化,促进黏痰排出。清理细菌繁殖的环境,致病性减弱,炎症缓解,炎症的恶性循环被打破。经桉柠蒎治疗的患者与常规治疗比较,疗效更为显著,患者使用安全,依从性好,且价格合理,患者经济负担小。桉柠蒎已被纳入《国家基本医疗保险、工伤保险和生育保险药品目录(2017年版)》。
雾霾引起咳嗽最为多见,急性咳嗽多为上呼吸道感染的症状,而慢性咳嗽主要由上气道咳嗽综合征(upper airway cough syndrome,UACS)又称为鼻后滴漏(流)综合征(postnasal drainage syndrome,PNDs)引起。李谊等[17]对50例由变应性鼻炎(AR)引起的UACS患者所进行的随机分组对照研究显示,常规治疗基础上加桉柠蒎治疗2周的治愈率(92%)明显高于不加桉柠蒎组(68%)(
雾霾引起的急、慢性咽喉炎也极为常见。张青松等[19]对286例慢性咽炎患者采用随机分组对照研究,在使用珍黄丸治疗的基础上加服桉柠蒎治疗15 d后有效率(84.1%)显著高于未加服桉柠蒎者(64.2%)(
雾霾是慢性鼻-鼻窦炎的重要诱发因素。鼻腔、鼻窦部黏膜炎症的恶性循环是该病复发与迁延难愈的重要原因。对于慢性鼻-鼻窦炎,除了抗炎(鼻内糖皮质激素和14员环大环内酯类药物)治疗外,黏液溶解促排剂也是重要药物[20]。杭伟等[21]对288例慢性鼻-鼻窦炎患者开展随机对照研究,慢性鼻-鼻窦炎患者被分为治疗组(常规药物治疗加桉柠蒎治疗)和对照组(仅常规药物治疗),疗程结束后随访 3,6,12个月,主、客观评价结果显示,常规治疗加桉柠蒎治疗组较常规治疗组疗效明显提高(
功能性鼻内镜手术(functional endoscopic sinus surgery,FESS)围术期(术前1~2周,术后3~6个月)使用新型黏液溶解促排剂对于炎症分泌物的排出、清理、重建和恢复术腔黏膜环境,打破炎症的恶性循环十分有益。李伟利等[22]对61例接受功能性鼻内镜手术治疗的慢性鼻窦炎、鼻息肉患者开展的随机对照研究表明,在进行常规围手术期处理的基础上,加服桉柠蒎肠溶软胶囊(术前每次0.3 g,tid,连续 3~4 d;术后第2天开始,每次 300 mg,tid,连续3~4周,后改为每次300 mg,bid,连续2~4 周)。结果显示,加服桉柠蒎组术后内镜黏膜形态评分情况优于常规治疗组,其术腔清洁情况和术腔上皮化情况优于未使用者(
慢性支气管炎(chronic bronchitis,CB)作为老年常见病,病程长、易反复、不易治愈。雾霾中的致病微生物可致CB急性发作。反复急性发作终致COPD和肺心病等危重病症。控制CB急性发作以抗感染、镇咳及祛痰为主。因老年患者咳痰无力,痰难咳出,抗菌药物的疗效亦受影响。顾勇[24]对240例慢性支气管炎急性发作期的患者开展的随机对照研究证明桉柠蒎肠溶软胶囊配合常规抗感染治疗CB急性发作疗效显著。
COPD是一种以持续气流受限为特征的疾病。雾霾易诱发和加重COPD。COPD患者黏液纤毛清除功能受损,黏液增多,排出受阻,气道阻力增加,病原菌易驻留,增加感染概率。能够改善和恢复黏液纤毛清除系统功能的药物有利于气道引流,改善通气功能,对控制 COPD 进展有重要意义。邓燕等[25]对117例稳定期COPD患者开展随机双盲对照研究显示,在《慢性阻塞性肺疾病全球倡仪》指南推荐的常规治疗基础上加服桉柠蒎肠溶软胶囊(0.3 g,bid,疗程12个月)的患者,在减少COPD急性加重次数、减轻症状和提高患者生活质量上优于对照组。
综上所述,新型黏液溶解性祛痰药桉柠蒎肠溶软胶囊有助于清除雾霾中的有害颗粒物,有助于人体抵抗雾霾中致病微生物的侵害,有助于雾霾相关疾病的治疗。
The authors have declared that no competing interests exist.
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Abstract Poor air quality is one of the most important environmental problems in many large cities of the world, which can cause a wide range of acute and chronic health effects, including partial physiological disorders and cardiac death due to respiratory and cardiovascular diseases. According to the latest edition of the national standard for air quality, maximum contamination level is 15 g/m3 per year and 35 g/m3 per day. The aim of this study was to evaluate cardiovascular, respiratory, and total mortality attributed to PM2.5 in the city of Mashhad during 2013. To this end, the Air Q model was used to assess health impacts of PM2.5 and human exposure to it. In this model, the attributable proportion of health outcome, annual number of excess cases of mortality for all causes, and cardiovascular and respiratory diseases were estimated. The results showed that the number of excess cases of mortality for all causes and cardiovascular and respiratory diseases attributable to PM2.5 was 32, 263, and 332 g/m3, respectively. Moreover, the annual average of PM2.5 in Mashhad was obtained to be 37.85 g/m3. This study demonstrated that a high percentage of mortality resulting from this pollutant could be due to the high average concentration of PM2.5 in the city during 2013. In this case, using the particle control methods, such as optimal use of fuel, management of air quality in urban areas, technical inspection of vehicles, faster development of public transport, and use of industrial technology can be effective in reducing air pollution in cities and turning existing situations into preferred ones.
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Results of epidemiological studies suggest a significant impact of ambient particulate matter air pollution (PM10 and PM2,5) on the health of the population. Increased level of these pollutants is connected with increased rate of daily mortality and hospitalizations due to cardiovascular diseases. Among analyzed health effects, heart arrhythmias and stroke are mentioned most frequently. The aim of the study was to present the current knowledge of potential influence of the exposure to fine particulate matter on the presence of arrhythmias and strokes. Subject literature review suggests, that there is a link between short-term exposure to fine dust and the occurrence of arrhythmias. Results of previous studies indicates that this exposure may lead to significant electrophysiological changes in heart, resulting in higher susceptibility to cardiac rhythm abnormalities. In case of stroke, a stronger correlation between number of hospitalizations and death cases and exposure to fine dust was seen for ischaemic stroke than for haemorhhagic stroke. In addition, a significantly more harmful impact of the exposure to ultra particles (particles of aerodynamic diameter below 2,5 m) has been confirmed. Among important mechanisms responsible for observed health impact of particulate matter there are: induction and intensification of inflammation, increased oxidative stress, increased autonomic nervous system activity, vasoconstriction, rheological changes and endothelial dysfunction. Among people of higher susceptibility to fine dust negative health impact are: elderly (over 65 years old), obese people, patients with respiratory and cardiovascular diseases, patients with diabetes and those with coagulation disorders. For further improvement of general health status, actions aimed at reducing the risk associated with fine dust and at the same time at continuing studies to clarify the biological mechanisms explaining the influence of fine dust on human health are necessary.
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Abstract In the past two decades, epidemiological studies have shown that air pollution is one of the causes of morbidity and mortality. In this study the effect of PM10, PM2.5, NO2, SO2 and O3 pollutants on human health among the inhabitants of Mashhad has been evaluated. To evaluate the health effects due to air pollution, the AirQ model software 3.3.2, developed by WHO European Centre for Environment and Health, was used. The daily data related to the pollutants listed above has been used for the short term health effects (total mortality, cardiovascular and respiratory mortality, hospitalization due to cardiovascular and respiratory diseases, chronic obstructive pulmonary disease and acute myocardial infarction). PM2.5 had the most health effects on Mashhad inhabitants. With increasing in each 10 g/m3, relative risk rate of pollutant concentration for total mortality due to PM10, PM2.5, SO 2 , NO 2 and O 3 was increased of 0.6%, 1.5%, 0.4%, 0.3% and 0.46% respectively and, the attributable proportion of total mortality attributed to these pollutants was respectively equal to 4.24%, 4.57%, 0.99%, 2.21%, 2.08%, and 1.61% (CI 95%) of the total mortality (correct for the non-accident) occurred in the year of study. The results of this study have a good compatibly with other studies conducted on the effects of air pollution on humans. The AirQ software model can be used in decision-makings as a useful and easy tool. Copyright 2016 Elsevier Inc. All rights reserved.
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Our study, the first to analyse daily particle OP measures and mortality and admissions in a large population over two years, found little evidence to support the hypothesis that short-term exposure to particle OP is associated with adverse health effects. Further studies with improved exposure assessment and longer time series are required to confirm or reject the role of particle OP in triggering exacerbations of disease.
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Introduction: Salivary gland-type cancers are rare lung neoplasms involving mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ACC), and epithelial-myoepithelial carcinoma (EMC). Their behavior and prognostic features are not clearly defined because of their low incidence. We retrospectively analyzed the clinicopathologic profiles of these tumors in a large series. Methods: Eighty-eight patients confirmed as having primary salivary gland-type lung cancer between May 2001 and January 2013 were included from the archives of two thoracic oncology center institutions in China and retrospectively evaluated. Results: Of the total 88 patients, 69 were MEC, 12 ACC, and seven EMC. Overall survival (OS) at 3, 5, and 10 years was 91.3%, 86%, and 80.6% in all cases, respectively, and disease-free survival (DFS) was 90.1%, 78.6%, and 55%, respectively. No significant difference was found among MEC, ACC, and EMC groups regarding OS (p = 0.518) and DFS (p = 0.082). Tumor-node-metastasis stage, lymph node involvement, intrathoracic invasion, and margin status were found to be related with OS (p = 0.000, 0.029, 0.000, 0.004) and DFS (p = 0.018, 0.042, 0.002, 0.002). Intrathoracic invasion was an independent predictor for OS (hazard ratio [HR], 1.129; p = 0.039) and DFS (HR, 1.071; p = 0.011). For patients with MEC, pathological grade also was an independent predictor of OS (HR, 0.045; p = 0.006) and DFS (HR, 0.067; p = 0.001). Conclusions: Salivary gland-type lung cancers are a group of low-aggressive entities with higher tendency to recurrence/metastasis. Intensive clinical, radiological, and pathological examinations are essential to estimation of the risk stratification and management.
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This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.
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开展短期内高浓度空气污染造成的人体健康风险评价以及健康经济损失研究，对推进城市大气污染防控，保证人民群众的健康水平具有重要的科学价值和实际意义．研究选择2013年1月发生的北京市雾霾重污染事件，采用泊松回归模型评价全市居民对10～15日高浓度PM2.5 暴露的急性健康损害风险，并采用环境价值评估方法估算人群健康损害的经济损失．结果：表明，短期高浓度PM2.5 污染对人群健康风险较高，约造成早逝201例，呼吸系统疾病住院1056例，心血管疾病住院545例，儿科门诊7094例，内科门诊16881例，急性支气管炎10132例，哮喘7643例．相关健康经济损失高达4．89亿元（95％CI：2．04～7．49），其中早逝与急性支气管炎、哮喘三者占总损失的90％以上．建议应针对不同人群不同健康终点的健康风险进行健康预警并开展及早医学干预，以降低类似空气重污染事件给居民健康带来的风险和损失．
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中国的鼻科学在过去15年间有了长足发展,鼻内镜微创外科技术有了显著提高,相对而言鼻科学基础研究水平较薄弱,然其鼻生理学和病理生理学研究前景广阔,与临床工作有较多结合点。人类鼻腔的生理功能主要包括:呼吸功能、鼻阻力、嗅觉功能、黏液纤毛清除功能、过滤功能、空气调节功能、免疫功能、感知功能和嗓音共鸣功能等,多数功能具备相应的临床评估手段。
DOI:
Magsci
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DOI:10.1002/alr.21878
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Introduction Myrtol standardized is a phytomedicine obtained by distillation, consisting of many constituents. In vitro and in vivo, the major monterpenes, d-limonene, 1,8-cineole, and alpha-pinene, are used as biological marker substances. Myrtol standardized has secretolytic, secretomotor, and mucolytic effects in addition to anti-inflammatory and antioxidative actions. The aim of the study was to investigate the effects of different concentrations of Myrtol standardized on in vivo mucociliary clearance in mice and the ciliary beat frequency (CBF) in rat tracheal rings. Methods Data regarding the effects of 1,8-cineole and N-acetylcysteine (NAC) were compared. Salbutamol was used as a positive control. CBF was measured using rat tracheal explants and a high-speed video camera linked to a microscope with specific software equipment. Mucociliary clearance was determined using the microdialysis technique, which measured the acceleration of a fluorescent sample in the trachea in vivo. Results Myrtol standardized accelerated both CBF and mucociliary transport in a concentration-dependent manner. Significant effects were seen at a concentration of 0.01% Myrtol regarding CBF ( P < 0.01) and 17.1 mg/kg body weight regarding mucociliary clearance experiments ( P < 0.05) according to doses relevant to humans. The 1,8-cineole dosage relative to humans only accelerated the mucociliary clearance in vivo without having an effect on the CBF. Extremely high doses of Myrtol were not able to additionally increase the CBF effect in comparison to salbutamol. Compared to NAC, also used in a dosage relative to humans, Myrtol standardized showed a tendency to be more effective. Conclusion In summary, the present data suggest that Myrtol standardized is a pharmacologically important drug which, when used at a dose relative to humans, shows positive effects on both measured parameters, CBF and mucociliary clearance, in vivo.
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Abstract BACKGROUND: This study was designed to observe the effects of myrtol standardized (Gelomyrtol forte), a secretomucolytic phytomedicine, on both ciliary beat frequency (CBF) in vitro and mucociliary transport time (MTT) in vivo. METHODS: Changes in cultured human nasal CBF in response to immediate treatment with 75, 150, or 300 ng/mL of myrtol standardized and prolonged treatment (12 or 24 hours) with 300 ng/mL of myrtol standardized were quantified by using high-speed digital microscopy. In addition, MTT before and after oral application of myrtol standardized (three times a day, 900 mg/day, 10 days) was determined using the saccharine test, and the effects of this treatment regime on nasal patency was measured by acoustic rhinometry and active anterior rhinomanometry in 22 patients with nonallergic chronic rhinitis. Another 10 patients without medication, who had the same examinations twice with a 10-day interval, were involved as controls. RESULTS: Neither immediate nor prolonged treatment with myrtol standardized produced a distinguishable change in CBF. Meanwhile, only in patients with treatment, MTT, as well as a unilateral minimum cross-sectional area, the volume of 0-5 cm inside the nasal cavity, the unilateral nasal resistance at 75 Pa and total symptom visual analog score were significantly improved after treatment. CONCLUSION: Based on these results we propose that a 10-day treatment with an herbal medicine, myrtol standardized, improves nasal mucociliary clearance as well as nasal patency in patients with chronic rhinitis. However, it has no impact on ex vivo CBF.
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目的：探讨桉柠蒎肠溶软胶囊治疗变应性鼻炎（AR）引起的上气道咳嗽综合征的临床效果、简易性及安全性。方法对50例由AR引起的上气道咳嗽综合征患者按随机原则随机分为治疗组和对照组（各25例）。所有病例确诊后，随机分为桉柠蒎肠溶软胶囊治疗组和对照组，对照组给予地氯雷他定片（成人和12岁以上儿童5 mg/天）口服，1次/日，共7 d；鼻用血管收缩剂（呋麻滴鼻液）3滴/次，2次/日，共7 d；口服甘草远志合剂20 ml，3次/日，共7 d；口服抗生素1周，首选克拉霉素缓释胶囊、糠酸莫米松鼻喷雾剂。治疗组在对照组治疗基础上加服桉柠蒎肠溶软胶囊，0.3 g/次，3次/日，餐前30 min用较多凉开水送服，7 d为1个疗程（4～10岁儿童0.12 g/次）。治疗组和对照组各用2个疗程（第2个疗程停服呋麻滴鼻液），直至临床症状缓解，观察临床疗效、并发症等情况。结果治疗组治愈率占92%。治疗中治疗后均未见明显并发症发生。所有病例均经1年以上随访，效果满意；对照组治愈率占68%，部分患者仍有咳嗽等不适症状。治疗组和对照组治疗结果比较：两者差异显著，有统计学意义（χ2=4.50，P＜0.05）。结论桉柠蒎肠溶软胶囊治疗AR引起的上气道咳嗽综合征有较好的临床效果，由于是口服制剂，大大减少了输液反应的并发症。
[本文引用:1]
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| [18] |
目的研究分析采用桉柠蒎肠溶软胶囊治疗鼻后滴漏综合征引起的咳嗽的临床效果。方法选取2013年1月至2015年1月在我院呼吸内科收治的150例鼻后滴漏综合征引起的咳嗽的患者,将患者随机分为两组各75例。对照组给予常规治疗加氨溴索胶囊治疗,治疗组给予常规治疗加桉柠蒎肠溶软胶囊治疗。对比分析两组患者的临床治疗效果、咳嗽次数、呼吸频率、咳痰量情况。结果治疗组临床治疗有效率明显高于对照组,差异显著（P〈0.05）。结论桉柠蒎肠溶软胶囊治疗鼻后滴漏综合征引起的咳嗽疗效确切,具有临床应用价值。
[本文引用:1]
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| [19] |
目的 观察标准桃金娘油治疗慢性咽炎的疗效.方法选择 286例慢性咽炎患者,随机分成两组,两组病人均使用珍黄丸口服,研究组加用标准桃金娘油口服,15d为一疗程,观察两组病例的疗效.结果研究组有效率 84.1%,显著高于对照组有效率64.2%(P<0.001),患者治疗期间无明显不良反应.结论标准桃金娘油是治疗慢性咽炎的一种安全有效药 物.
[本文引用:1]
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| [20] |
前 言 慢性鼻-鼻窦炎(chronic rhinosinusitis,CRS)是耳鼻咽喉头颈外科的常见病,是鼻窦及鼻腔的慢性炎性疾病.其发病与许多因素有关,病理生理学机制复杂,诊断和治疗对临床医师具有挑战性.为提高慢性鼻-鼻窦炎的诊断准确性和治疗水平,1995年,我国鼻科学者制订了"广州标准"[1].尽管当时对其病因和发病机制的认识远不及今天,但应该说,"广州标准"(1995)以及后来在此基础上制订的"海口标准"(1997)[2],对起步不久的我国鼻内镜外科技术的规范化应用都具有重要的引导意义.
[本文引用:1]
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| [21] |
目的探讨桉柠蒎治疗慢性鼻-鼻窦炎（CRS）的疗效。方法将CRS患者随机分为治疗组和对照组,予常规药物治疗及加用桉柠蒎治疗,疗程结束后予主客观的评估,分析桉柠蒎的疗效。结果常规及加用桉柠蒎治疗后,随访3、6、12个月,加用桉柠蒎组较常规治疗组疗效有明显提高,差异有统计学意义。结论桉柠蒎肠溶软胶囊作为一种黏液溶解促排剂,对CRS有良好的疗效,值得临床推广。
[本文引用:1]
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| [22] |
目的 观察桉柠蒎肠溶胶囊在慢性鼻窦炎、鼻息肉内镜手术围手术期应用对术后术腔恢复的影响.方法 将61例接受功能性鼻内镜手术治疗的慢性鼻窦炎、鼻息肉患者随机分为治疗组31例和对照组30例.两组进行常规的围手术期一般处理:术前均给予抗菌药物静脉滴注,qd,连续3～4 d;术后均给予抗菌药物静脉滴注,qd,连续5～7 d;后改为口服抗菌药物约1周.术后第3天清理术腔填塞藻酸钙敷料,第4天开始给予0.9%氯化钠溶液鼻腔冲洗,每天1或2次,连续2个月.并用盐酸布地奈德喷鼻,每次每侧2喷,bid;1周后,每次1喷,qd,连续3个月.治疗组口服桉柠蒎肠溶胶囊,术前每次300 mg,tid,连续3～4 d;术后第2天开始服用,每次300 mg,tid,连续3～4周,后改为每次300 mg,bid,连续2～4周.两组患者于术后1,2,3,4,6,8,12,16,22周行内镜检查,记录术腔情况.结果 治疗组术后术腔内镜黏膜形态评分,总分≤5分27例,总分＞5分4例,对照组分别为17和13例.治疗组术后内镜黏膜形态评分情况优于对照组,差异有统计学意义(χ2=9.02,P＜0.01).结论 内镜鼻窦手术围手术期使用桉柠蒎肠溶胶囊有助于加快术后黏膜恢复,提高手术疗效;桉柠蒎肠溶胶囊为理想的内镜鼻窦手术围手术期辅助用药.
[本文引用:1]
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| [23] |
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| [24] |
目的观察桉柠蒎肠溶软胶囊治疗慢性支气管炎急性发作的临床疗效。方法将240例患者按照住院号单双号分为治疗组和对照组各120例，均予吸氧、解痉平喘。治疗组加用桉柠蒎肠溶软胶囊0．3/次，口服，3次/d；对照组加用盐酸氨溴素口服液10ml／次，口服3次／d，两组均以7d为1个疗程。1个疗程后评价疗效。结果治疗组临床治愈、显效、有效、无效分别为53例（4417％）、43例（35．83％）、16例（13．33％）、8例（6．67％），对照组分别为26例（21．67％）、36例（30．00％）、37例（30．83％）、21例（17．50％），治疗组临床疗效明显优于对照组（P〈0．05）。两组治疗前后肝肾功能、心电图、大小便常规均无明显变化。结论桉柠蒎肠溶软胶囊配用常规抗感染治疗慢性支气管炎急性发作疗效显著。
[本文引用:1]
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| [25] |
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