HERALD OF MEDICINE

Pharmacokinetics of Cordycepin and Its Metabolite 3'-Deoxyinosine in Rats

HU Nan, JIANG Zhenwei, QIAN Minyan, ZHANG Wenting, CHEN Lujun, ZHENG Xiao, YING Hanjie, JIANG Jingting

Herald of Medicine, 2024, 43(3): 345-351. DOI: 10.3870/j.issn.1004-0781.2024.03.003

Fig.1 Structures of cordycepin (Cor),3 '-deoxyinosine (3' -Deo)and internal standard 2-chloradenosine (2-Chl)

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Fig.2 LC-MS/MS chromatograms of Cor,3'-Deo and 2-Chl in rat plasma A.blank plasma;B.blank plasma spiked with standard;C.rat plasma after administration.
Tab.1 Accuracy and precision of Cor and 3'-Deo $\bar{x}$±s,n=6
Tab.2 Extraction recovery and matrix effect of Cor and 3'-Deo %, $\bar{x}$±s,n=6
Fig.3 Stability of Cor in plasma at different temperatures and times($\bar{x}$±s,n=6) A.room temperature;B.4℃;C.-20 ℃;D.-80 ℃.
Fig.4 Degradation of Cor and production of 3 '-Deo at room temperature($\bar{x}$±s,n=6) A.Cor 1.5 ng·mL^-1;B.Cor 7.5 ng·mL^-1;C.Cor 75 ng·mL^-1.
Tab.3 Result of Stability test for Cor %,$\bar{x}$±s,n=6
Tab.4 Result of Stability test for 3'-Deo %, $\bar{x}$±s,n=6
Tab.5 Pharmacokinetic parameters of Cor and 3'-Deo after intragastric administration of Cor in rats $\bar{x}$±s,n=6
Fig.5 Mean plasma concentrations-time curves of Cor (A)and 3'-Deo (B)after intragastric administration of Cor (10 mg·kg^-1)in rats