HERALD OF MEDICINE

Pharmacokinetics of Cordycepin and Its Metabolite 3'-Deoxyinosine in Rats

HU Nan, JIANG Zhenwei, QIAN Minyan, ZHANG Wenting, CHEN Lujun, ZHENG Xiao, YING Hanjie, JIANG Jingting

Herald of Medicine, 2024, 43(3): 345-351. DOI: 10.3870/j.issn.1004-0781.2024.03.003

浓度/ (ng·mL^-1)	室温15 min	4 ℃ 30 min	-20 ℃ 48 h	-80 ℃ 48 h	自动进样器8 h	冻融1次
1.5	88.1±7.5	99.1±4.1	91.8±4.1	93.3±5.3	113.3±5.8	92.4±3.8
7.5	94.5±3.2	98.3±5.7	92.2±5.7	91.4±8.5	105.5±5.9	90.2±3.6
75	85.1±7.3	90.4±2.9	91.9±8.0	89.3±1.8	103.0±8.0	86.2±5.0

Tab.3 Result of Stability test for Cor %,$\bar{x}$±s,n=6

Other figure/table from this article

Fig.1 Structures of cordycepin (Cor),3 '-deoxyinosine (3' -Deo)and internal standard 2-chloradenosine (2-Chl)
Fig.2 LC-MS/MS chromatograms of Cor,3'-Deo and 2-Chl in rat plasma A.blank plasma;B.blank plasma spiked with standard;C.rat plasma after administration.
Tab.1 Accuracy and precision of Cor and 3'-Deo $\bar{x}$±s,n=6
Tab.2 Extraction recovery and matrix effect of Cor and 3'-Deo %, $\bar{x}$±s,n=6
Fig.3 Stability of Cor in plasma at different temperatures and times($\bar{x}$±s,n=6) A.room temperature;B.4℃;C.-20 ℃;D.-80 ℃.
Fig.4 Degradation of Cor and production of 3 '-Deo at room temperature($\bar{x}$±s,n=6) A.Cor 1.5 ng·mL^-1;B.Cor 7.5 ng·mL^-1;C.Cor 75 ng·mL^-1.
Tab.4 Result of Stability test for 3'-Deo %, $\bar{x}$±s,n=6
Tab.5 Pharmacokinetic parameters of Cor and 3'-Deo after intragastric administration of Cor in rats $\bar{x}$±s,n=6
Fig.5 Mean plasma concentrations-time curves of Cor (A)and 3'-Deo (B)after intragastric administration of Cor (10 mg·kg^-1)in rats